Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Tissue Microenvironment"”.
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Cellular Kaleidoscope: Unveiling Tissue Microenvironment in Health and Disease
… organisms, cells are organised into tissues, where groups of similar cells work together to perform specific tasks. Understanding how tissues and organs function requires insight into the dynamics between different cell populations. Changes in this composition and gene expression …
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Mechanics and transport characterization of bioengineered tissue microenvironment platforms
The tissue microenvironment is a complex living system containing heterogeneous mechanical and biophysical cues. Cellular components are surrounded by extracellular matrix and interstitial fluid, while transport of nutrients and biochemical factors is achieved via the vasculature. Each constituent …
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Exploring the complexities of the tissue microenvironment using high throughput protein microarrays
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Role of biomechanics and tumor microenvironment in osteosarcoma progression
… of tumor heterogeneity, mechanobiology and the tissue microenvironment. It aims to understand the different influences, physical and biochemical, present in the osteosarcoma tissue microenvironment and connect them to give a broader understanding of the tumor microenvironment and the …
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Label-free multi-modal multiphoton imaging for real-time point-of-procedure assessment of needle biopsies
… and biochemical distributions in biological tissue, especially in tumor microenvironments. Continuous efforts have been devoted to the development and optimization of an intraoperative label-free multimodal NLOI system that integrates four NLOI modalities: two- and three-photon fluorescence, …
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The application of deep learning to nucleus images for early cancer diagnostics
… usually involves a pathologist looking at tissue slices of patients for specific features associated with cancer prognosis such as nuclear morphometric measures. However, early diagnosis remains a major challenge. Recent studies have shown that changes in fibroblast nuclei play a critical …
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Ras Drives Malignancy Through Stem Cell Crosstalk with the Microenvironment
… aberrant signaling crosstalk with their tissue microenvironment that drives their malignant progression. Surprisingly, the non-genetic, dynamic cascade of crosstalk involves pathways often mutated in advanced metastatic SCCs with a high mutational burden. Coupling our clonal skin HRASG12V …
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Defining The Role of Il-15 Trans-Presentation By Distinct Cell-Types During The Development and Homeostasis of Natural Killer and Invariant Natural Killer T Cells
… via trans-presentation is determined by the tissue site and the maturation status of NK and iNKT cells. For NK cells, I revealed the non-hematopoietic compartment provides IL-15 to NK cells in the early stages of development while hematopoietic cells were crucial for the generation and …
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Cellular plasticity in white adipose tissue: in vivo identification of bipotent adipocyte progenitors in adult white adipose tissue
… composition and phenotype of white adipose tissue (WAT). Nonetheless, the identity of progenitors that contribute to this cellular plasticity in vivo remains poorly understood. Utilizing genetic lineage tracing techniques in combination with in situ imunohistochemical analysis, we …
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Synergistic development of an engineered biodegradable theranostic probe and lymph node organ-on-a-chip to study nanoparticle-lymphatic interactions
… this, cancer often reshapes the lymphatic microenvironment and metastasizes into lymph nodes. Theranostic (therapeutic + diagnostic) nanoparticles have been used in a variety of applications, including the detection and treatment of cancer metastases in lymph nodes. However, accumulation in …
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Developing a 3D in vitro Model by Microfluidics
<p><em>In vitro</em> tissue models play an important role in providing a platform that mimics the realistic tissue microenvironment for stimulating and characterizing the cellular behavior. In particular, the hydrogel-based 3D <em>in vitro</em> models allow the cells to grow and interact with their …
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A multimodal lens into vascular recovery in a preclinical model of peripheral arterial disease
… can exert far reaching effects on the ischemic tissue microenvironment, and may provide clinical improvement for PAD patients in the future.
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The Influence of Immunization Route On The Adjuvant Effect of Alpha-Galactosylceramide
… anergy in the lung. The outcome in the other tissues analyzed was mixed and could be the result of tissue microenvironment among others possible reasons. When intranasal dosing preceded systemic, NKT cells were reactivated to produce IFNγ and induced positive adaptive immune responses in the …
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Methods for chemical exchange saturation transfer magnetic resonance imaging
… technique that generates contrast dependent on tissue microenvironment, such as protein concentration and intracellular pH. CEST imaging has the potential to become an important biomarker in a wide range of disorders. As an indicator of tissue pH, CEST imaging may allow the identification of the …
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Role of Gsh Metabolism In Mediating Stromal-Leukemia Interaction and Promoting Cell Survival and Drug Resistance In Chronic Lymphocytic Leukemia
… stable and abundant precursor cystine from the tissue environment and convert it to cysteine intracellularly. I showed that CLL cells had limited ability to take up extracellular cystine for GSH synthesis due to their low expression of the transporter Xc-, but had normal ability to uptake …
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Exploring the role of IRF4 in the sensitivity of mantle cell lymphoma cells to Bruton's Tyrosine Kinase inhibitors
… protected from BTKi effects within the local tissue microenvironment. This thesis develops previous work by the group identifying IRF4 as a central mediator of resistance to BTK inhibitors in MCL; the thesis aims to understand how resistance develops and to identify mechanisms to prevent or …
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3D Bioprinting of Advanced Bioinks for Tissue Engineering Applications
… would be the first option for those whose tissues/organs have been extremely injured. However, the growing gap between the number of organ donors and receivers has resulted in the long waiting list for organ transplantation. Regenerative medicine has emerged as a promising approach to …
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Exploring the Multifaceted Life of Beige Adipocytes
… to morbidity and mortality worldwide. Adipose tissue lies at the center of this issue. However, it is increasingly recognized that it is the quality of fat, rather than its quantity alone, that has a greater impact on metabolic health. While excess accumulation of lipid-storing white adipocytes …
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DEVELOPMENT OF NOVEL BIOTECHNOLOGICAL APPROACHES FOR ACCELERATING GENETIC GAIN IN THE BOVINE
… biological scaffold that mimics the native tissue microenvironment, preserving its structural, biomechanical, and biochemical properties. This scaffold was designed to support in vitro meiosis. The final set of experiments focused on isolating and characterizing key functional testicular …
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Soft tissue viscoelastic properties: measurements, models and interpretation
… quantification of mechanical properties of soft tissues has been of great interest for more than two decades because they have the potential of being used as biomarkers for disease diagnosis. Indentation techniques, the most recognized techniques for characterizing mechanical properties, are …
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