Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Tissue Heterogeneity"”.
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Unsupervised Signal Deconvolution for Multiscale Characterization of Tissue Heterogeneity
Characterizing complex tissues requires precise identification of distinctive cell types, cell-specific signatures, and subpopulation proportions. Tissue heterogeneity, arising from multiple cell types, is a major confounding factor in studying individual subpopulations and repopulation dynamics. …
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Mathematical Modeling and Deconvolution for Molecular Characterization of Tissue Heterogeneity
Tissue heterogeneity, arising from intermingled cellular or tissue subtypes, significantly obscures the analyses of molecular expression data derived from complex tissues. Existing computational methods performing data deconvolution from mixed subtype signals almost exclusively rely on supervising …
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Characterization of p-type silicon semiconductor detectors for use in in vivo dosimetry
… exit doses could be improved by the inclusion of tissue heterogeneity correction factors in the treatment planning algorithm.
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Using a voxel-based krogh cylinder array to simulate microvascular contrast enhancement
… between and inside image elements. To do this, tissue parameter maps were created, contrast agent was introduced to the tissue via a flow lattice, and various data sets were simulated. The effects of sources, tissue heterogeneity, and the contribution of individual tissue parameters to an image …
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The Distribution of Histone Polypeptides and It's Methylated Basic Amino Acids from the Various Organs of the Rat
… histone components does not exhibit any form of tissue heterogeneity.</p> <p>The five histone components (F<sub>1</sub>, F<sub>2a2</sub>, F<sub>2b</sub>, and F<sub>2a1</sub>) from the nuclei of the cerebellum, cerebrum, liver, thymus and lidney of forty-six 15 days old albino rats, which had …
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Collective Dynamics of Interacting Cell Types
… single-cell technologies allow us to dissect tissue heterogeneity at the level of individual cells. For the theoretical sciences, this wealth of data provides a unique opportunity to synthesize general principles that unify the variability observed across diverse organisms. This thesis focuses …
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Imaging Based Prediction of Pathology In Adult Diffuse Glioma With Applications to Therapy and Prognosis
… measured by histologic and molecular analysis of tissue samples. However, the well-known spatial heterogeneity in gliomas limits the ability for clinicians to use that information to make spatially specific treatment decisions. Magnetic resonance imaging (MRI) visualizes and assesses the tumor. …
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Computational Dissection of Composite Molecular Signatures and Transcriptional Modules
… on extracting pure gene expression signals from tissue or cell mixtures. The main goal of gene expression profiling is to identify the pure signatures of different cell types (such as cancer cells, stromal cells and inflammatory cells) and estimate the concentration of each cell type. In order to …
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Single molecule techniques to probe decision-making processes in developmental biology
… bulk assays and qualitative imaging of cell and tissue heterogeneity. There are few options that allow for quantitative, high-resolution, single-cell analysis that is robust but not associated with a high degree of technical difficulty or obscured by amplification. Here, we address these issues …
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Advancing techniques for engineered tissue models of the bone marrow
… models that capture the hypoxic nature and heterogeneity of natural tissues such as the bone marrow are difficult to develop. Oxygen tension is known to play a role in several physiological processes, such as wound healing and angiogenesis. Though the bone marrow is a hypoxic tissue, …
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Resolving the evolution of Oesophageal Adenocarcinoma using spatial and temporal sampling
… Furthermore, the considerable intra-tumour heterogeneity (ITH) may underlie the observed chemo-resistance. There have not been any large-scale studies to assess ITH in OAC and associated BO. Aside from multi-region sequencing, another way of overcoming sampling bias of the heterogeneous …
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Restoration of Bone Material and Microstructural Properties after Long-Term Remodeling Suppression
… of bone resorption adversely affects bone tissue mechanical properties, even while conserving bone mass. Lack of remodeling leads to accumulation of fatigue-induced microdamage, altered matrix mineralization and reduction in normal bone tissue heterogeneity, causing impaired strength and …
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Development Of Single-Cell Transcriptomic & Epigenomic Sequencing Technologies To Assess Cell-Type-Specific Gene Regulatory Programs In Mammalian Brains
… to gain a high-resolution understanding of how tissue heterogeneity impacts human health, development, and disease. These technologies have become so powerful and popular in such a short period of time, and scientists and entrepreneurs alike are beginning to realize their potential. Concerted …
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Multispectral Imaging of Skin Oxygenation
… technique for quantitative measurement of skin tissue oxygen saturation (StO2). Oxygen saturation is the percentage of oxygen carried in the blood over the total oxygen carrying capacity of blood. Skin StO2 is an important indicator of skin tissue clinical status. Measurement of skin tissue …
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Measurements and analysis of the microwave dielectric properties of tissues
… of the microwave dielectric properties of human tissues is essential for the understanding and development of medical microwave techniques. In particular, microwave thermography relies on processes fundamentally determined by the high frequency electromagnetic properties of human tissues. The …
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Modeling of carbonization and stalling during radiofrequency ablation and electrosurgery
… in the 100 kHz-1 MHz range to biological tissues. These currents generate electric fields that drive ionic oscillations in intracellular and extracellular fluids, producing localized resistive heating. Depending on the applied waveform, duty cycle, and exposure duration, this heating can …
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Novel approaches to MRI of glioma
… that results in distortion and disruption of tissue architecture. Gliomas are characterised by an increase in cells of variable sizes, as well as changes in the tissue microstructure. Diffusion-Weighted Imaging (DWI) and the apparent diffusion coefficient (ADC), have been extensively studied …
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Machine Learning Approaches for Modeling and Correction of Confounding Effects in Complex Biological Data
With the huge volume of biological data generated by new technologies and the booming of new machine learning based analytical tools, we expect to advance life science and human health at an unprecedented pace. Unfortunately, there is a significant gap between the complex raw biological data from …
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Classification of atherosclerotic plaque vulnerability by mechano-radiomics
… Radiomics is an emerging technique to evaluate tissue heterogeneity. Whilst extensively investigated in oncology, there is limited application of these techniques in MR carotid plaque characterisation. Radiomic features may provide better phenotyping of carotid plaques. Mechanics and radiomic …
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Statistical Machine Learning for Multi-platform Biomedical Data Analysis
… microarrays. The research work focuses on: (1) tissue-specific compartmental analysis for dynamic contrast-enhanced MR imaging of complex tumors; (2) computational Analysis for detecting DNA SNP interactions in genome-wide association studies. DCE-MRI provides a noninvasive method for evaluating …