Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"Timolol"”.
-
Evaluation hämodynamischer Effekte von Timolol, Dorzolamid und Latanoprost bei Patienten mit neu diagnostiziertem Offenwinkelglaukom
… angiography to compare the hemodynamic effect of timolol, dorzolamide and latanoprost in newly diagnosed patients with open angle glaucoma. Methods: 14 patients with newly diagnosed open angle glaucoma received randomley either timolol, dorzolamide or latanoprost for four weeks after baseline …
-
Perioperative Administration of Topical Dorzolamide Hydrochloride/Timolol Maleate Reduces Postoperative Ocular Hypertension in Dogs Undergoing Cataract Surgery
… approach and that dorzolamide hydrochloride/timolol maleate (DHTM) may be more efficacious than other pressure lowering medications. The canine literature on POH prophylaxis is limited and DHTM has not yet been evaluated despite common use in the clinical setting. Our objectives, therefore, …
-
Drug delivery strategies to overcome ocular hypertension
… for sustained, local delivery to the eye. Timolol prodrugs, synthesized to self-assemble into CDAs, were developed to avoid the systemic spikes in drug concentration associated with conventional timolol eye drops. Of the synthesized prodrugs, timolol palmitate displayed the most promising …
-
Pentablock copolymers based controlled release formulations of small and macromolecules for ophthalmic applications
… any burst effect. Further, release profile of timolol from composite formulations was evaluated for glaucoma therapy. We observed that composite approach could provide sustain release of timolol for longer duration. Successful accomplishment of this project may lead to application of this …
-
Advanced Engineering of Contact Lens Coatings using Electrohydrodynamic Atomization
… selected to develop coatings for the delivery of timolol maleate (TM); with the intention of achieving sustained drug release for treatment of glaucoma. The work presented here is a proof-of-concept; showing the versatility of a promising technique by applying it to a DD remit within which EHDA …
-
Hydrogen Sulfide in Glaucoma: Delivery System, Hypotensive and Neuroprotective Effects
… IOP by 26%, comparable than the marketed drug timolol (27%). Pretreating OSL-4 with glutathione further decreased the IOP by 32.3%. Lastly, the neuroprotective effects of H2S on the bovine retina were evaluated with H&E, TUNEL, glutathione, and superoxide dismutase assays. The biochemical …
-
Intracellular calcium mobilization in cardiomyocytes of rats with experimental diabetes
… sustained [Ca2+]; decrease which was blocked by timolol (0.1 pM) and thapsigargin (1 pM) suggesting the SR Ca-ATPase was involved in this fl-adrenergic stimulated [Ca24]i response. In electrically-paced myocytes, isoproterenol caused a dose dependent increase of[Ca2÷]i. The maximum response was …