Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Time-to-Event Analysis"”.
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Evaluating Alpha Spending Functions Applied to Observational Time-to-Event Analysis
… setting of randomized controlled trials (RCTs) to observational studies with time to event analyses. In these less structured environments, key design parameters such as the total number of events are often unknown, posing challenges for the standard implementation of sequential analysis …
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Advances in Time-to-Event Analysis: Big Data Applications in Cancer Risk Prediction
… of health care provides new opportunities to study dis- ease and gain unprecedented insights into the underlying biology. With the wealth of data generated, new statistical challenges arise. This thesis will address some of them, with a particular focus on Time-to-Event analysis. The Cox …
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A comparative study of dementia-related service provision and configuration in Canada
The purpose of this study was to describe and compare the provision of dementia-related services throughout the disease trajectory. Previously collected interview data from family physicians, geriatric specialists, and case managers in Calgary, Edmonton, and Ottawa (n=34) using a standardized …
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Statistical Analysis of Treatment Compliance for Clinical Trials using Electronic Compliance Monitoring
Compliance, the extent to which patients follow a medication regimen, has been recognized as one of the most serious problems facing medical practice today. Recent developments in assessing compliance include electronic compliance monitors (ECM), devices that record the date and time of the release …
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Improving the accuracy of statistics used in de-identification and model validation (via the concordance statistic) pertaining to time-to-event data
Time-to-event data is very common in medical research. Thus, clinicians and patients need analysis of this data to be accurate, as it is often used to interpret disease screening results, inform treatment decisions, and identify at-risk patient groups (ie, sex, race, gene expressions, etc.). This …
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Characterizing and evaluating student dropout through understanding student’s journey in a MicroMasters program
… the world can complete a series of MOOC courses to achieve microcredentials. However, the high dropout problem in MOOCs also persists in MOOC based programs, with the additional complexity of open enrollment. This study provides a framework to characterize dropout in a MOOC based program using …
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Resource Selection, Survival, and Departure of Adult Female Mallards From The Lake St. Clair Region During Autumn And Winter
… through their spatiotemporal distribution to avoid mortality risks while balancing trade-offs to access foods to undergo migration and maintain homeostasis. Thousands of mallards use Lake St. Clair as it is an important, but threatened, migratory staging area in the Great Lakes. My goal was …
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Potentially Inappropriate Medication Use In Older Patient With Breast and Colorectal Cancer
<p>Our objective was to determine predictors of potentially inappropriate medication (PIM) use and its impact on outcomes (including ER visits, hospitalization, all cause death, and composite of three) in breast and colorectal cancer patients receiving chemotherapy.<strong> </strong>We used data …
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Probabilistic Time-to-Event Modeling Approaches for Risk Profiling
… providing opportunities for machine learning to build statistical models to support clinical practice. Time-to-event analysis, also called survival analysis, stands as one of the most representative examples of such statistical models. Models for predicting the time of a future event are …
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Essays in Asset Management: Mutual Funds and Exchange-traded Funds
… dissertation consists of three essays related to fund management, and in particular, mutual funds (MFs) and exchange-traded funds (ETFs). The first essay studies the decision by an asset manager to launch an exchange-traded fund (ETF). Fund families focus on both revenue generation and cost …
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EVALUATION, DEVELOPMENT, AND EXTENSION OF FLEXIBLE PARAMETRIC MODELS FOR THE DISTRIBUTIONAL ANALYSIS OF CENSORED AND NON-CENSORED DATA: A FRAMEWORK FOR MODELING AND COMMUNICATING THE FULL DISTRIBUTION OF HEALTH OUTCOMES.
Background: Time-to-event analysis is a cornerstone of medical research, yet standard methods often rely on restrictive assumptions that limit their clinical utility and causal interpretability. The Hazard Ratio (HR), while popular, suffers from non-collapsibility and lacks a straightforward causal …
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The application of Bayesian adaptive design and Markov model in clinical trials
… adaptive dose-finding design with longitudinal analysis and its application in phase II depression clinical trial. This design is best fit for phase II dosing-finding clinical trials with clinical endpoints. MTD information has been obtained before the trials. In adaptive dose-finding clinical …
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Comparative Effectiveness of Analgesic Sedation as Primary Sedation in Medical ICU Patients vs. Conventional Sedation and Analgesia Regimens
… are considered the standard of care to optimize patient safety and comfort during MV. Although the use of analgesics, sedatives, and antipsychotic therapies in the ICU is commonplace; adverse effects, unpredictable pharmacokinetics, and inappropriate dose titrations often hinder …
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Analysis of clustered competing risks with application to a multicentre clinical trial
The usefulness of time-to-event (survival) analysis has made it gain a wide applicability in statistically modelling research. The methodological developments of time-to-event analysis that have been widely adopted are: (i) The Kaplan-Meier method, for estimating the survival function; (ii) The …
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Marginal donor characteristics and outcomes after liver transplantation
… the population age is increasing rapidly over time. There is a growing need for donor livers as the number of critically unwell recipients awaiting liver transplantation increases. The extended criteria donor liver has been increasingly utilised in an attempt to balance the equation. There are …