Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 106 for “"Tight Junction"”.
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Targeting the tight junction : immunotherapy of colon cancer
A33 is a cell surface glycoprotein of colon epithelium with a long clinical history as a target in antibody-based cancer therapy. Despite being present in normal colon, radio-labeled antibodies against A33 are selectively retained by tumors at long time points. Accordingly, we have studied the …
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Charakterisierung der Funktion des Tight Junction Proteins hu-CLDN1 und seine Bedeutung bei der Tumorgenese
… wurden erstmals die wahrscheinlich wichtigsten Tight Junction Proteine, Claudin-1 und -2 in der Maus beschrieben. An Hand von Sequenzhomologien konnten bis heute dieser 4 Transmembrandomänen Proteinfamilie 18 Mitglieder mit unterschiedlichen Gewebeverteilungen zugeordnet werden. Parallel zum …
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Hemodynamic regulation of blood-brain barrier phenotype: A cooperative effort linking adherens and tight junction complexes
Intercellular adherens junction (AJ) and tight junction (TJ) proteins (e.g. VE-Cadherin, occludin, ZO-1, claudin-5) jointly consolidate the apical surface of adjacent brain microvascular endothelial cells (BBMvEC’s) creating the blood-brain barrier (BBB), a critical regulator of CNS homeostasis. …
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Schlussleisten (Zonulae occludentes) und biochemisch verwandte Strukturen: Tight Junction-Proteine und -Funktionen in mehrschichtigen Epithelien, mit besonderer Berücksichtigung der Plattenepithelmetaplasie
… einem bestimmten Epithelgewebe gekoppelt. Die „Tight Junctions“ (TJ) sind dabei für die Herstellung und Aufrechterhaltung der unterschiedlichen molekularen Zusammensetzungen der einzelnen Kompartimente, vor allem als Haupt-Barriere für die parazelluläre Ausbreitung von Zellen, Partikeln und …
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Colonic metabolism of dietary grape seed extract: Analytical method development, effect on tight-junction proteins, tissue accumulation, and pan-colonic pharmacokinetics
… seed extract increased the expression of gut junction protein occludin and reduced levels of fecal calprotectin, which suggests an improvement of gut barrier integrity and a potential modulation of endotoxemia. Additionally, chronic supplementation of the diet with flavanols did not increase …
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THE ROLE OF TIGHT JUNCTION PROTEIN ZO-2 IN THE NUCLEUS AND ITS LINK TO TRANSCRIPTION FACTORS OF THE SLUG/SNAIL FAMILY
… with the transmembrane proteins of the tight junction (TJ). It is capable of shuttling between the TJ and the nucleus and is known to participate in gene regulation through its association with gene regulators. To identify proteins interacting with ZO-2, a yeast two-hybrid screen was …
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Mechanisms of methylenedianiline toxicity to rat biliary epithelial cells
… glucose, suggesting that DAPM loosens hepatic tight junctions. Early ultrastructural alterations in BEC mitochondria, however, suggested a possible role of mitochondrial dysfunction in the ability of BEC to maintain glucose transport and tight junction integrity. The working hypothesis for this …
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MOLECULAR PHYSIOLOGY OF BLOOD-BRAIN BARRIER TIGHT JUNCTIONS
… of the BBB see from the perspective of its tight junctions (TJ). Tight junctions are a protein-protein adhesion structures that seal the paracellular space for small solutes. Tight junctions are a common feature in many epithelial and endothelial tissues and a crucial component of the BBB. …
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Effect of probiotics or high incubation temperature on gene expression and cell organization of the small intestine and yolk sac of chicks
… structure of epithelial cell-lined villi with tight junctions between adjacent cells. Probiotics have been reported to improve chicken growth performance and gut health including promotion of intestinal morphology. However, there are few studies that show the effect of probiotics on ontogeny of …
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Effect of Diabetes Mellitus on Ocular Surface Tight Junctions and Glycocalyx
… prevalence of dry eye disease. Impairment of tight junctions and glycocalyx, which are critical for ocular surface barrier function, may underlie these diabetes-associated ocular surface defects. Therefore, the present study was designed to investigate the effect of high glucose exposure and …
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Modelling the gastric epithelium for testing of new chemical entities
… dosage forms. A successful model should exhibit tight junction formation, maintenance of differentiation and polarity. Conditions for primary culture of guinea-pig gastric mucous epithelial cell monolayers on Tissue Culture Plastic (TCP) and membrane insects (Transwells) were established. Tight …
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Do Probiotics Protect Against the Deleterious Effects of a High-Fat Diet?
… metabolic dysregulation and degradation of tight-junction proteins between intestinal cells. Probiotic supplementation is the practice of ingesting live strains of bacteria that are proposed to have a beneficial effect on the host by enriching the intestine with healthy bacteria. The purpose …
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Role of Extracellular Signal-Regulated Kinase (ERK) in Regulation of Intestinal Epithelial Tight Junctions
… (ERK1/2) is involved in regulation of epithelial tight junctions. There are different opinions expressed by investigators as to whether ERK disrupts the junctions or protects them. ERK has also been demonstrated to mediate the EGF-caused protection of the intestinal epithelial tight junctions (TJ) …
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Acetaldehyde and Epithelial Junctions: Role of Pp2A and Occludin Phosphorylation
… can enter the bloodstream when gastrointestinal tight junctions, protein complexes that prevent paracellular passage of molecules, are compromised. The mechanisms of this barrier disruption are the subject of current study.</p> <p>Acetaldehyde, produced as a result of ethanol breakdown by …
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Mechanistic insight into the role of dietary fibers and short chain fatty acids in the regulation of metabolism and inflammation in the pig
… effect of butyrate on cell integrity and tight junction expression with LPS stimulation in porcine intestinal epithelial cells (IPEC-J2) was determined. Butyrate prevented LPS-induced impairment on the intestinal barrier integrity and tight junction permeability in a dose-dependent manner, …
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Role of Myosin Light Chain Kinase in Binge Ethanol and Burn Injury-Induced Intestinal Barrier Dysfunction
… (MLCK), an enzyme important for epithelial tight junction maintenance, has been implicated in barrier alterations after burn injury or ethanol exposure alone. With this knowledge, <underline>we hypothesize that the combination of binge ethanol exposure and burn injury causes an increase in …
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The role of the gut microbiota in the function and integrity of brain barriers
… confocal microscopy for visualization of the tight junction protein, ZO-1, germ-free mice were found to have a disruption of the tight junction protein networks in isolated choroid plexus tissue. Similar assessment of the choroid plexus capillaries revealed no difference between germ-free and …
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INVESTIGATION OF ACUTE STRESS IMPACT ON NURSERY PIG GASTROINTESTINAL FUNCTION AND ABILITY OF BIOACTIVE COMPONENTS OF GARLIC TO MITIGATE STRESS-INDUCED PHYSIOLOGICAL CHANGES
… markers and altered intestinal morphology and tight junction gene expression during the first week post-weaning. Furthermore, the acute post-weaning deprivation event impacted growth performance throughout the nursery period and resulted in pigs 0.57 kg lighter at 28 d post-weaning. A second …
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hiPSC-Derived Cerebral Small Vessel Disease Models
… role ECM plays in cSVD. These mutations induced tight junction abnormalities with Occludin discontinuity and Claudin-5 accumulation in hiPSCs-derived Brain Microvascular Endothelial Cells (iBMECs), which resulted in decreased TEER levels and increased permeability. They also induced apoptosis, …
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