Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Tigecycline"”.
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Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Acute Myeloid Leukemia
… a screen and identified the antimicrobial tigecycline (TIG). Methods: Primary AML mononuclear cells were isolated by Ficoll centrifugation from peripheral blood. Flow cytometry dye; JC-1, Carboxy-H2DCFDA, Mitotracker GreenFM. Leukemia stem cell activity was assayed by human AML engraftment …
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Developments in the Mutant Prevention Concentration: A Novel Approach to Antimicrobial Susceptibility/Resistance Issues
… and the modified microbroth dilution MPC method. Tigecycline is the first of a new class of compound – glycylcyclines- with potent in vitro activity against Gram-positive organisms including penicillin-resistant and multi-drug resistant Streptococcus pneumoniae (SP) and methicillin-resistant …
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Measuring the abundance, diversity and overlap of Antimicrobial Resistance genes associated with humans, livestock and the environment in low- and middle-income country settings
… in response to meropenem, ciprofloxacin and tigecycline exposure. A good concordance was observed between Fluidigm HT-qPCR and RNA-seq in measuring differential gene expression upon exposure to antimicrobials. My work substantiates the application of microfluidics in the study of AMR and …
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Acquisition of an Antibiotic Tolerant Phenotype in Enterobacter cloacae and Klebsiella pneumoniae through Antibiotic-Induced Metabolic Regulation
… analysis was performed on ertapenem and tigecycline treated organisms to identify metabolic pathways that were differentially expressed between treated and untreated isolates. I identified the methylglyoxal pathway as a candidate pathway that bacteria can use to acquire antibiotic …
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Utilization of Model-Based Approaches to Maximize Efficacy of Antibiotics for the Treatment of Mycobacterium abscessus Pulmonary Infection
… to enable successful clinical treatment. Tigecycline (TGC), one of the preferred drugs listed in treatment guidelines for Mab-PI, has demonstrated excellent therapeutic efficacy, including in CF patients. However, its clinical utility is limited by its narrow therapeutic window and …
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Nasopharyngeal carriage with Staphylococcus aureus in healthy children during the first year of life - The Drakenstein Child Health study
… of isolates. All isolates were susceptible to tigecycline, linezolid and mupirocin. A strong relationship between the spa-clonal complexes and antimicrobial resistance phenotypes was noted. We also documented shifts in the resistance patterns over time within the same genotype carried by the …
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Elucidation of the Molecular Mechanisms That Contribute to Variation in Susceptibility Testing Show the Need for Alternative Detection Methods of KPC-producing Gram-negative Bacteria
… in blaKPC gene expression with gentamicin and tigecycline, both of which are used in the treatment of KPC-producing pathogens. Of note, non-β-lactam drugs influenced blaKPC gene expression more often than the β-lactam drugs, but strain to strain variation occurred. The third hypothesis was that …