Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Tiam1"”.
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New roles of Rac-GEFs in Neutrophils and in Glucose Homeostasis
… cytoskeletal dynamics controlled by the Rac-GEF Tiam1 in neutrophil adhesion/migration. We previously found a paradoxical increase in the adhesion of Tiam1–/– neutrophils (unpublished). This was surprising, as deficiencies in other neutrophil Rac-GEFs impair adhesion. I showed deregulated …
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Mechanisms of regulation of islet function by nadph oxidase
… generation of ROS; ii) contributory roles of Tiam1-Rac1-Nox signaling in free fatty acid (e.g., palmitate) and cytokines- induced â-cell dysfunction. Findings from current study suggest that posttranslational prenylation is a requisite for signaling G-proteins involved in the activation of Nox …
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Targeting Ph Domain Proteins For Cancer Therapy
… PH domain proteins. Interestingly, we found Tiam1, a guanine nucleotide exchange factor (GEF) specific for Rac1 activation, was overexpressed in several cancers, particularly neuroendocrine prostate cancer.</p> <p>Targeting PH domain proteins remains to be a significant challenge for multiple …
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The Effects of Acetylenic Tricyclic Bis-(Cyano Enone) on Cell Migration
… of the polarity proteins Rac1, IQGAP and Tiam1 were altered from the leading edge of migrating cells. Lastly, TBE-31 was shown to inhibit Rat2 and NIH3T3 fibroblast as well as H1299 non-small cell lung cancer tumour cell migration. Taken together, my work provides novel insights on the …
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Investigating the immunosuppressive functions of the GPCR adapter protein Norbin
… active in Ncdn<sup>Δmye</sup> neutrophils, and Tiam1 which is upregulated to cell surface upon C5a-stimulation. I also showed that the elevated ROS production in these cells can be reversed by titrating inhibitors of Rac and Erk.<br> Arguably my most important contribution was to investigate the …
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Mechanisms Of Cytokine-Induced Metabolic Dysfunction Of The Pancreatic Beta-Cell
… of Vav2-Rac1 axis] and NSC23766 [inhibitor of Tiam1-Rac1 axis] attenuated cytokine-induced JNK1/2 activation implying that Rac1 is upstream to cytokine-induced JNK1/2 activation. Based on the results obtained from my studies, I propose that protein palmitoyl transferase is a novel therapeutic …
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Rho GTPases in Neuronal Apoptosis and Neurodegeneration
… Rac GTPase activation by the Rac-specific GEFs Tiam1 and Trio. Targeted inhibition of Rac GTPase via NSC23766 treatment in CGNs evoked apoptosis via repression of unique MEK5/ERK5, p90Rsk, and Akt-dependent pro-survival pathways. Furthermore, selective inactivation of Rac induced the activation …