Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"Thyroid cancer"”.
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Leveraging copper chelators as targeted therapy for BRAFV600E mutant thyroid cancer
<p>The incidence of thyroid cancer, and in particular papillary thyroid cancer (PTC), is rising faster than that of any other malignancy in the United States. Thyroid cancer is now the most common endocrine cancer and the fifth most common cancer in women. While most thyroid cancers are treated …
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In vitro studies on new therapeutic approaches for human thyroid cancer
Thyroid cancer is the most prevalent endocrine malignancy, and its incidence has been increasing. It has been reported that Type I receptor for transferrin (TfR1/CD71) is expressed on malignant cells at levels several fold higher than those on normal cells and its expression can be correlated with …
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Time to surgery and thyroid cancer survival in the United States
Over the past several decades, the incidence of thyroid cancer in the United States has increased substantially surmounting to higher levels of concern for physicians around the nation. This concern led to a research investigation surrounding the increased risk thyroid cancer patients may face by …
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Pre-operative diagnosis of thyroid cancer : clinical, radiological and pathological correlation
… the accuracy of pre operative diagnosis of thyroid cancer in a single centre. Secondary Aims: evaluate the impact of preoperative diagnosis on surgical interventions for thyroid carcinoma; develop locally applicable guidelines for patients with nodular disease of the thyroid.
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The Impact of Family History On Medullary Thyroid Cancer In Men2A Patients
<p>The American Thyroid Association recently classified all MEN2A-associated codons into increasing risk levels A-C and stated that some patients may delay prophylactic thyroidectomy if certain criteria are met. One criterion is a less aggressive family history of MTC but whether families with the …
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Changes of Clinicopathological Characteristics and Prognosis of Papillary Thyroid Cancer in Korea
Thyroid cancer is the most frequent endocrine tumor and increased across the world, especially in micropapillary thyroid cancer under 1 centimeter. Increased incidence of thyroid cancer was attributed to early diagnosis by health screening with neck ultrasonography and fine needle aspiration …
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CHARACTERIZATION OF EPCAM IN THYROID CANCER BIOLOGY BY THREE-DIMENSIONAL SPHEROIDS IN VITRO MODEL.
Thyroid cancer (TC) is the most common Endocrine malignancy. Currently, the mechanisms responsible for insensitivity to therapeutic treatments, tumor aggressiveness and tumor relapse described in undifferentiated thyroid cancers (UTCs) haven’t been fully elucidated yet. The insurgence of therapy …
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A NOVEL BRAF SIGNALING CASCADE THROUGH p-21 ACTIVATED KINASES REGULATES THYROID CANCER CELL MOTILITY
Papillary thyroid cancer (PTC) is the most frequently diagnosed form of thyroid cancer, representing the majority of all cases. For unknown reasons it is more commonly diagnosed in women then in men and over the past three decades, its incidence has been rising in the United States. It is unclear …
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Relation between F-18 FDG Uptake of PET/CT and BRAFV600E Mutation in Papillary Thyroid Cancer
… are potential prognostic factors of papillary thyroid cancer (PTC). This study was performed to investigate the relationship between the BRAFV600E mutation and F-18 FDG uptake in PTC. MATERIALS AND METHODS: We retrospectively included 169 PTC patients who underwent F-18 FDG positron emission …
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Investigation of microRNA expression in thyroid carcinoma among South Africa patients
Objective: Thyroid cancer affects approximately 298 million people worldwide and the major challenge is reliably distinguishing patients who present with poor prognosis from those who do not. There are genetic markers that have been shown to be associated with poor clinical outcome in thyroid …
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A quantitative risk assessment of exposure to nitrates in drinking water and thyroid disorders in East Anglia, United Kingdom
… to nitrates in drinking water is associated with thyroid disorders, including mild - to - moderate iodine deficiency; hyperthyroidism; hypothyroidism; thyroid hypertrophy (goitre) and thyroid cancer. However, the weight of evidence following a meta – analysis is strongest for goitre; weak for …
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Investigating the Role of Complex I Loss in Thyroid Tumorigenesis
… are considered one of the hallmarks of cancer. In 1924, Otto Warburg initially posited that defects in cellular respiration drive tumorigenesis after observing that tumor cells often perform aerobic glycolysis in culture. Since then, multiple studies have demonstrated that most tumors …
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NODULI TIROIDEI NELL'ACROMEGALIA: RUOLO DELL'ELASTOSONOGRAFIA
… to be a helpful tool for the diagnosis of thyroid cancer. In acromegaly multinodular goiter is a common occurrence while the prevalence of thyroid cancer is still debated. Aims were to evaluate thyroid nodules in acromegaly and to establish the accuracy of US-E in providing information on …
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Diagnostic Procedures Using Radiation and Risk of Thyroid Cancer: Causal Association or Detection Bias? An Examination of Population Cancer Trends and Data from the NYC Fire Department
<p>Background: Thyroid cancer (TC) is a common cancer diagnosis in the United States, whose incidence is increasing. Disaster and radiation treatment studies show high doses of radiation can cause TC. Some diagnostic procedures, whose use is increasing, expose individuals to low-dose radiation but …
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Variation-aware algorithms for cancer genome analysis
… explore variation-aware algorithms for analyzing cancer genomes. The scientific community has extensively catalogued millions of mutations present in cancer cells. This information is rarely used during read alignment and variant calling because of a lack of algorithms for doing so. Rediscovering …
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RET receptor activation targets expression of the pleiotropic cytokine interleukin-11
… constitutively active forms of RET can lead to thyroid neoplasia. Missense mutations are causative agents in multiple endocrine neoplasia type 2 (MEN 2), featuring medullary thyroid carcinoma (MTC), whereas RET fusion oncoproteins generated by gene rearrangements are associated with papillary …
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Identification of gene expression changes in human cancer using bioinformatic approaches
… to identify gene expression changes relevant to cancer. The advent of genome-wide expression profiling techniques, such as microarrays, has provided powerful new tools to identify such changes and researchers are now faced with an explosion of gene expression data. Processing, comparing and …
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Predicting risk of malignancy in patients with indeterminate thyroid nodules
Thyroid cancer is the most prevalent endocrine cancer (1). The prevalence of palpable thyroid nodules in the general adult population is 4% to 7% (2). Ultrasound imaging detects thyroid nodules in 19%-68% of randomly selected individuals (3). The rate of thyroid cancer in nodules found on US is 4% …
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Evaluation of Desmoplasia, Inflammatory Markers, and Nutritional Status for Predicting Recurrence in Low-to-Intermediate Risk Differentiated Thyroid Cancer [Valutazione di desmoplasia, markers infiammatori e stato nutrizionale per la predizione del rischio di recidiva nel carcinoma differenziato della tiroide a rischio basso-intermedio]
Il carcinoma differenziato della tiroide (DTC) è la neoplasia endocrina più frequente. Un sottogruppo di pazienti a rischio basso-intermedio presenta una probabilità di recidiva non trascurabile e non è chiaro in quali casi è necessario trattare questi pazienti con terapia I131 dopo …
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