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Showing 1 to 4 of 4 for “"Thyroid Hormone Synthesis"”.
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Functional Characterization of the C-terminal Cholinesterase-Like (ChEL) Domain of the Thyroid Hormone Precursor Protein
<p>Vertebrate life is unsustainable without thyroid hormones. The only known precursor for thyroid hormone synthesis is thyroglobulin (Tg), composed of upstream regions I-II-III and a C-terminal cholinesterase-like (ChEL) domain, which bears 47% similarity to acetylcholinesterase (AChE). Mutations …
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MOLECULAR RECOGNITION OF THYROGLOBULIN BY SORTILIN
… (TG) is a large glycoprotein essential for thyroid hormone synthesis and storage. Synthesised and secreted by thyrocytes, TG forms a dimeric structure within the thyroid follicle lumen, where it undergoes iodination and hormonogenesis before being retrieved through endocytosis for hormone …
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Alterations in cerebellar protein synthesis in propylthiouracil-induced hypothyroid rats
Thyroid hormones play an important role in the regulation of gene expression and cerebellar development in the rat. The drug propylthiouracil was used to disrupt thyroid hormone synthesis. This permitted investigation of gene expression under three different states of hormonal deprivation: early in …
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Radiobiological effects of the thyroid gland - transcriptomic and proteomic responses to 131l and 211At exposure
… targeting molecules or as halide to target the thyroid or thyroid cancer. 211At is proposed for radionuclide therapy and preclinical and clinical research on 211At-labeled tumor targeting molecules is on-going. The thyroid gland accumulates both 131I and 211At as halides and is an organ at risk. …