Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Thymopoiesis"”.
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Promoting Thymopoiesis with Age: Potential Role of the Transcription Factor Foxn1
… to attenuation of the age-associated decline in thymopoiesis. In addition, the decline in the number of bone marrow-derived T cell progenitors is prevented in Foxn1Tg. Using adaptive transfer experiments, I demonstrated that the aged Foxn1Tg BM microenvironment promotes the development of T cell …
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Characterization of Stress Responsive MicroRNAs and Their Roles in T Cell Development
… miRs would be stress responsive and modulate thymopoiesis. Thymic miR profiling revealed 18 distinct miRs that are dysregulated more than 1.5-fold in response to lipopolysaccharide or the synthetic glucocorticoid dexamethasone. These stress-responsive miRs are dynamically regulated in distinct …
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DISSECTING IMMUNE DYSREGULATION IN PATIENTS WITHTHYMIC EPITHELIAL TUMORS BY AUTOANTIBODY ANDSINGLE-CELL PROFILING
… type AB, B1, B2 thymomas, retained intratumoral thymopoiesis, whereas type A, A-MNT, B3 thymomas and TC were predominantly infiltrated by mature T cells. Within this spectrum each histotype showed distinctive features: B1 thymomas supported efficient thymopoiesis and released CD4, CD8 and Vδ1 …
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Characterization of Non-Coding RNAs in Regulating Thymic Epithelial Cell Responses to Pathophysiological Stress
… thymus involution and the subsequent recovery of thymopoiesis. The work presented in this thesis characterizes an epithelial specific miR, miR-205, and its surrounding long noncoding RNA, MIR205.001 in regulating TEC functions. A deficiency of miR-205 specifically in TECs renders these cells more …
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Effects of Thymus Size and Involution On The Contribution of Recent Thymic Emigrants to The Peripheral T Cell Pool
… Thymus involution results in decreased thymopoiesis and RTE output leading to a reduced diversity of peripheral T cells. This increases susceptibility to disease and impairs immune responsiveness to vaccines. Therefore, studies aimed at maintaining or regenerating thymic function are …
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Preventing Thymus Involution In K5.Cyclin D1 Transgenic Mice Sustains The Naïve T Cell Compartment With Age
… transgene in thymic epithelial cells (TECs). Thymopoiesis occurs normally in K5.D1 transgenic thymi and sustains T cell output to prevent the age-associated decline of naïve T cells in the periphery. We find that K5.D1 recent thymic emigrants (RTEs) undergo typical phenotypic maturation. In …
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IDENTIFYING, CHARACTERIZING AND VERIFYING NOVEL C-MAF FUNCTIONS IN T CELL DEVELOPMENT AND APOPTOSIS
… our studies show that c-Maf also regulates thymopoiesis. Largely independent of c-Myb and IL-4, overexpression of c-Maf influences thymocyte apoptosis, proliferation and emigration. Overall, c-Maf coordinates multiple processes including development and survival of T cells. Knowledge gained …
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Nicotine and TNF alpha, modulators of T cell signaling-effects on T cell development in fetal thymus organ culture
… model to reconcile the role of TNF-alpha in thymopoiesis with its role in diabetes. Our data indicate that thymocytes from NOD FTOC express lower levels of TNF receptors and produce more TNF-alpha compared to non-diabetic C57BL/6 (B6) FTOC. Neutralization of endogenous TNF-alpha in NOD FTOC …
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RNA binding proteins ZFP36 and ZFP36L1 limit CD8+ T cell differentiation and effector function
… ZFP36L1 and ZFP36L2 act redundantly during thymopoiesis and in developing B lymphocytes, where they limit DNA damage response and cell cycle progression. Furthermore, ZFP36L2 has been shown to repress translation of preformed Ifng mRNA and maintain quiescence in CD8+ memory T-cells. However, …
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The role of Lymphoblastic leukemia 1 (Lyl1) in Mycobacterium tuberculosis (Mtb) infection
… been shown to serve a significant role during thymopoiesis by contributing to T-cell development. However, it has been recently reported that irrespective of its significance during T-cell development, mature comparable single positive T-cells are observed in mouse models. The use of murine …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… and hence the T cell repertoire. During thymopoiesis, the patterning of [Ca2+]i plays a pivotal role in selection of thymocytes. In 1987, Tellam & Parish described a sustained Ca2+ rise in DP thymocytes which depended on a transmembrane influx of Ca2+. The channel through which this Ca2+ …
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TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes
… and hence the T cell repertoire. During thymopoiesis, the patterning of [Ca2+]i plays a pivotal role in selection of thymocytes. In 1987, Tellam & Parish described a sustained Ca2+ rise in DP thymocytes which depended on a transmembrane influx of Ca2+. The channel through which this Ca2+ …
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Recent Thymic Emigrants and their Biomarkers
The main development of T cells takes place in the thymus. However, T cells that have just exited the thymus, called Recent Thymic Emigrants, are not yet fully matured and thus have different characteristics and functionalities than mature peripheral T cells. Several biomarkers exist for these …
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Abnormes Mikromilieu und gestörte Thymopoese in Thymomen als Grundlage der Autoimmunisierung im peripheren Immunsystem
Thymome sind die einzigen Tumoren, die reife T-Zellen aus unreifen Vorläuferzellen generieren, wobei die unreifen Thymozytenpopulationen in Thymomen im Vergleich zum Thymus abnorm vermehrt und die reifen Populationen vermindert sind. Zusätzlich weist das Thymomgewebe im Vergleich zum Thymus weniger …
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An investigation of the role of TRIB2 in steady state and stressed haematopoiesis
TRIB2 is a member of the mammalian Tribbles family of serine/threonine pseudokinases (TRIB1-3). Here, we studied murine haematopoiesis after Trib2 ablation under steady state and proliferative stress conditions, including genotoxic and oncogenic stress. At the steady state, we found that TRIB2 loss …