Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Thymocyte differentiation"”.
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The effects of nitrosoureas on Thymocyte differentiation and T cell activation
Earlier studies have demonstrated that nitrosoureas such as 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU) and chlorozotocin (CLZ) can cure almost 100% of C57BL/6 mice bearing syngeneic LSA tumor. In contrast, similiar or higher doses of streptozotocin (STZ) completely failed to cure LSA-bearing …
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Delineating the Role of CD244 in NK Cell Cytotoxicity and the Contribution of Ly108 to Thymocyte Development
… receptor, Ly108 in B6 and B6.Sle1b mice alters thymocyte differentiation and negative selection events leading to a break in tolerance of T cells in B6.Sle1b mice. This is due to differential affects of the isoforms of Ly108 on thymocyte cell cycle progression and sensitivity to apoptosis. These …
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Characterizing the Role of TLX1 in T-cell Acute Lymphoblastic Leukemia
… TLX15–7 . TLX1 expression has been shown to stop thymocyte differentiation, dysregulate gene expression, and promote oncogenic transformation by accumulating genetic lesions and aneuploidy5,6,8–12. Characterization of TLX1 T-ALLs has suggested recurrent secondary mutations and colocalization with …
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Aspects of T cell development contributing to autoimmunity.
… transfer. Our analysis revealed no difference in thymocyte distribution or apoptosis induction indicating that TGF-β is dispensable in these aspects. We did however observe increased proliferation of CD8+ thymocytes which might contribute to the immune defect in these animals. The impact of thymic …
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Enforced Expression of Tbx1 In Fetal Thymic Epithelial Cells Antagonizes Thymus Organogenesis
… immunohistochemical and FACS analysis of various differentiation markers. The relative level of <em>Foxn1 </em>expression in fetal TECs was significantly reduced. TECs in <em>R26<sup>iTbx1/+</sup></em> thymi assumed an almost universal expression of Plet-1, a marker associated with a TEC …
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Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus
… thymic epithelial cells (TEC) with migrating thymocytes is of fundamental importance in driving thymocyte differentiation and their selection towards generation of an immunocompetent but self-tolerant T cell repertoire. While the ontogeny, phenotype and functionality of TEC subsets has been …
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On Thymic Regulatory T-Cell Ontogeny
… of pathogens while preventing autoimmunity, the differentiation process of thymocytes is closely supervised by sequential programs, including the rearrangement of T-cell receptor (TCR) gene segments, β-selection of cells expressing a functional TCRβ chain, positive selection of cells followed by …