Global ETD Search
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Showing 1 to 2 of 2 for “"Thymineless death"”.
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The role of recombinational repair in the mechanism of killing during thymine starvation in Escherichia coli
Thymineless death (TLD) describes a universal phenomenon in which cells cannot recover after starvation for one of the four DNA precursors, dTTP. The mechanism of how cells lose viability during thymine starvation has remained a mystery for decades. In Escherichia coli, thymine-starved cells were …
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Study of mechanism of genetic death in Escherichia coli in response to A) dTTP starvation and B) combination of temperature sensitive defects in replication initiation and double strand break repair
… lipids), which can be classified as metabolic death of the cell, or by blocking the process of DNA replication and segregation (without affecting protein/RNA/lipid metabolism) – which we classify as genetic death of the cell. Irreparable DNA lesions, therefore, inflict genetic death on the …