Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Thymic Stromal Lymphopoietin"”.
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The Regulation and Function of Thymic Stromal Lymphopoietin Receptor (TSLPR) in the Airway Epithelium
The epithelially-derived cytokine thymic stromal lymphopoietin (TSLP) plays a key role in the development and progression of allergic disease and has notably been shown to directly promote the inflammatory responses that characterize asthma. Current models suggest that TSLP is produced by …
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Regulation of Intestinal Epithelial Thymic Stromal Lymphopoietin Gene Expression by Retinoic Acid Receptor Alpha
Inflammatory bowel disease is characterized by chronic inflammation of the gastrointestinal tract. The pathogenesis is thought to be due to a dysregulated immune response to intestinal microbiota. Approximately 15% of the risk is genetically linked and approximately 85% is attributed to …
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Comparative Studies of TSLP and IL-7 in Normal Early Human Neonatal and Adult B Cell Development
… to investigate the roles of the IL-7R ligands, thymic stromal lymphopoietin (TSLP) and IL- 7, in the early stages of normal postnatal and adult human B cell development. Using novel in vitro and in vivo model systems, we show that TSLP and IL-7 are able to expand B cell precursors individually …
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The Role of Mucosal Epithelial Cells In Hiv-1 Infection
… human cervical epithelial cells to produce Thymic Stromal Lymphopoietin (TSLP), an IL7-like cytokine, which potently activated human myeloid dendritic cells (mDC) to cause the homeostatic proliferation of autologous CD4+ T cells that serve as targets for HIV infection. Rhesus macaques …
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Factors Influencing Regulatory T Cell Maintenance for the Control of Autoimmunity
… on Treg numbers by producing the cytokine thymic stromal lymphopoietin (TSLP) in response to topical administration of the vitamin D3 analog MC903. Widespread increases in Tregs were observed in mice treated topically but not systemically with MC903. TSLP receptor (TSLP-R) but not …
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Computational and Experimental Investigation of the Critical Behavior Observed in Cell Signaling Related to Electrically Perturbed Lipid Systems
… negative breast cancer cells by abrogating thymic stromal lymphopoietin signaling and enhancing stimulatory proteins such as the tumor necrosis factor. Furthermore, experimental evidence produced during this Ph.D. research demonstrates that PEFs may not directly impact the intracellular …
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Local and Systemic Consequences of Reducing Notch Signaling in Skin Keratinocytes
… barrier sets off a systemic alarm by secreting thymic stromal lymphopoietin: TSLP), an epithelial-derived cytokine implicated in pathogenesis of asthma and atopic dermatitis. TSLP was highly expressed by Notch-deficient epidermis. Importantly, we were able to show that TSLP was both required and …
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Developing druggable in vitro models for investigating itch in atopic dermatitis
… reduced iPSCSN responses to the pruritogens thymic stromal lymphopoietin and interleukin-31, thus highlighting TRPA1 as a therapeutic target. In addition, other iPSCSN differentiation methods were explored and yielded functional TRPV1<sup>+</sup>, but TRPA1<sup>-</sup>, cells, which could be …
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TSLP-induced Mechanisms and Potential Therapies for CRLF2 B-cell Acute Lymphoblastic Leukemia
… the receptor signaling complex for the cytokine Thymic Stromal LymphoPoietin (TSLP) on the surface of B-ALL cells. TSLP has been shown to induce proliferation of human and mouse B-cell precursors via activation of the JAK-STAT5 and more recently the PI3K/AKT/mTOR pathways. However, the mechanisms …
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Reprogramming the immune environment in breast cancer via dendritic cells.
… we show that human breast cancer cells produce thymic stromal lymphopoietin (TSLP). Breast tumor supernatants, in a manner dependent on TSLP, induce expression of OX40L on dendritic cells (DCs). OX40L⁺ DCs are found in primary breast tumor infiltrates. OX40L⁺ DCs drive development of …
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Immune activation at the lung epithelial barrier
… we also found that epithelial-derived thymic-stromal lymphopoietin (TSLP) did not play a role in a mild model of HDM-induced asthma. However, the use of higher doses of HDM (inducing more severe asthma features) revealed a more important role for TSLP. In conclusion, this thesis shows …