Global ETD Search
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Showing 1 to 15 of 15 for “"Thymic Epithelial Cells"”.
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Enforced Expression of Tbx1 In Fetal Thymic Epithelial Cells Antagonizes Thymus Organogenesis
… expression of <em>Tbx1</em> in fetal thymic epithelial cells antagonizes</strong></p> <p><strong>thymus organogenesis</strong></p> <p>Kim T. Cardenas</p> <p>The thymus and parathyroid glands originate from organ-specific domains of 3rd pharyngeal pouch (PP) endoderm. At embryonic day …
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Wnt Secretion Proteins Modulate RANKL-Induced Expression of Aire in Thymic Epithelial Cells
<p>Thymic epithelial cells (TEC) are essential for a proper adaptive immune response by regulating thymocyte development and establishing central tolerance. In the thymus, TECs differentially express Wnt proteins, which activate canonical and non-canonical Wnt signaling pathways. Wnt signaling is …
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Epigenetic analysis of promiscuous gene expression in central tolerance
… restricted antigens (TRA) within medullary thymic epithelial cells in a process known as promiscuous gene expression (PGE). Here we demonstrate how AIRE influences PGE through a direct impact on post-translational modifications of core histones which are associated with the regulation of …
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Development and Maintenance of the Thymic Epithelial Microenvironment
… the functional self-tolerant T-cell population. Thymic epithelial cells play an essential role in the development of a naïve, self-tolerant T-cell population. Paradoxically thymus undergoes acute age-related involution, which in turn causes loss of functional T-cell populations. Involution …
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The development and function of thymic microenvironments
… a diverse and self-tolerant T-cell repertoire. Thymic epithelial cells (TEC) represent a key stromal cell type during defined stages in T cell development, yet the mechanisms regulating their development are only partly understood. An ontogenetic approach was employed to study stages of cortical …
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Determination of Thymic Epithelial Cell Composition and Proliferation During The Perinatal to Adult Transition
<p>T-cells develop in the thymus based on signaling from multiple stromal cell types, particularly thymic epithelial cells (TECs). The thymus develops rapidly during the perinatal time period (birth – 10 days in mice) before reaching a period of homeostasis (10 days – 6 weeks). The mechanisms that …
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Preventing Thymus Involution In K5.Cyclin D1 Transgenic Mice Sustains The Naïve T Cell Compartment With Age
… perpetual release of self-MHC restricted naive T cells. However, thymus involution during the aging process reduces naïve T cell output, leading to defective immune responsiveness to newly encountered antigens. We have found that early thymus involution precipitates the age-associated shift …
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Characterizing the role of thymic interferon in T cell development and selection
… induced during infections, where they protect cells against viral infection and activate immune cells. Curiously, both type I and type III IFNs were reported to be produced at low levels in the thymus in the absence of infection – the site of T cell development and a crucial organ for immune …
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The role of the atypical chemokine receptor CCX-CKR in thymocyte development and its influence on the link between innate and adaptive immunity through regulation of dendritic cell migration.
… and CCR9-expressing thymocytes through distinct thymic compartments, enabling development of a self-MHC restricted and self-tolerant peripheral T cell repertoire. Yet mechanisms outside of transcriptional control that are involved in thymic chemokine regulation have not been well characterised. …
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Promoting Thymopoiesis with Age: Potential Role of the Transcription Factor Foxn1
… (ETP) binds to its ligand expressed on thymic epithelial cells (TEC), signaling ETP to develop through a series of developmental stages before maturing into naive T cells. Because ETP are non-self renewing, the thymus relies on the bone marrow (BM) for a continuous supply of T cell …
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Investigating lymphocyte development in the foetal thymus and modulation by the melanocortin 5 receptor
… effective protective immunity. Innate lymphoid cells and T cells play central roles in orchestrating bespoke immune reactions by producing specialised repertoires of immuno-regulatory cytokines. ILC2 and natural killer (NK) cells are generated in the bone marrow and thymus, whilst T cell …
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Defining The Molecular Networks Necessary For Thymus Fate and Organogenesis
… pps). By E11.5 during mouse development, cells committed to the thymus lineage express <em>Foxn1 </em>whereas PT-fated cells express <em>Gcm2</em>. While these transcription factors are required for organ-specific differentiation, the exact molecular mechanisms that specify endodermal …
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Phenotypic and functional analysis of the mesenchymal stromal cell compartment in the thymus
T cells are key cellular components of the adaptive immune system that play a critical role in our defense against pathogens and cancer but also contribute to pathology in the setting of chronic inflammation and autoimmunity. The thymus constitutes the body's major T cell production site, where …
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Single-cell atlasing of the human tissues across the lifespan
… I provide an annotation and spatial mapping of T cells and supporting resident cells, including thymic epithelial cells (TECs), fibroblasts, vascular and myeloid cells. Simultaneously, I use the cortico-medullary axis to compare the spatial position of cell types in the fetal vs. paediatric …
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Comparative Immunological Effects of a Natural Estrogen (17β-estradiol) versus a Pharmacologic Synthetic Estrogen (17α-ethinyl estradiol)
… administered. Additionally, like E2, EE induced thymic atrophy in both sexes. In female mice, thymic atrophy and thymic cellularity were significantly decreased by subcutaneous EE and E2 at doses of 0.4 and 4.0 μg/25 g body weights. EE elicited significantly more pronounced thymic …