Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 91 for “"Thrombus"”.
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Stroke and intracardiac thrombus: A case series
Introducción: Los cardioembolismos son la causa de entre el 20% y el 40% de los ictus isquémicos. Hasta un 22% de los ictus cardioembólicos están relacionados con trombos intracardíacos y afectan a pacientes con una elevada carga de comorbilidad cardíaca. Objetivo y métodos: Describir la …
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Computational Modeling And Simulation Of Thrombus Formation
… a serious medical complication because excessive thrombus formation could lead to obstruction of blood vessels, resulting in tissue ischemia or death. This study is aimed to understand the cell-biology and biophysics, at the molecular level, of thrombosis in a blood vessel. We first review the …
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Surgical Strategy of Hepatocellular Carcinoma with Bile Duct Tumor Thrombus
… carcinoma (HCC) with bile duct tumor thrombus (BDTT) have not been well assessed. This study intended to research the surgical strategy of HCC patients with BDTT. Methods: From February 1994 to December 2012, 877 HCC patients underwent hepatic resection in Ajou University Hospital. …
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The Tetraspanin CD9 Localizes to Platelet-Platelet Contacts and Regulates Thrombus Stability
<p>CD9, a member of the tetraspanin family, is highly expressed on platelets (50,000-80,000 copies per platelet). Tetraspanins have been implicated in modulation of integrin function, and it is hypothesized that CD9 will modulate GPIIb-IIIa, the major platelet integrin.</p> <p> The association …
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Flow effect on thrombus formation in stenosed coronary arteries: a computational study
… Although the exact factors and events leading to thrombus formation are not entirely known, the local rheological conditions as well as the different tendency for clotting of the blood of each individual are considered to have an important role both in progress of the disease and the relevant …
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Computational model of intraluminal thrombus growth in abdominal aortic aneurysms with fibrin generation
Abdominal aortic aneurysms affect 0.2% of the population and are closely associated with intraluminal thromboses (ILTs) that develop in the sac. Advanced imaging and treatment techniques are available, however there is room for improvement in the methods used to predict the outcome or necessity of …
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THROMBUS GENERATION UNDER FLOW CONDITIONS IN PATIENTS WITH CIRRHOSIS AND THROMBOCYTOPENIA: THE CIRTAS-STUDY
… system based on a dedicated chip, the Total Thrombus Analysis System (T-TAS®) with HD-CHIP, is a new laboratory tool to assess the thrombus formation under flow in patients with thrombocytopenia, but has never been tested in cirrhosis. Aims: We assessed the reproducibility and accuracy of the …
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A Physio-chemical Predictive Model of Dynamic Thrombus Formation and Growth in Stenosed Vessels
… role in platelet-substrate interactions and thrombus formation and growth in blood flow, where under both pathological and physiological conditions platelet adhesion and accumulation occur. In this study, a three-dimensional dynamic model of platelet-rich thrombus growth in stenosed vessels …
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Delayed Thrombus Resolution and Fibroproliferative Vascular Wound Healing From Deficiency of Type Iii Collagen: A Paradoxical Mechanism For Tissue Fragility
… occlusive thrombi instead unmasks defective thrombus resolution resulting from impaired production of type III collagen, which causes deranged remodeling of matrix, persistent inflammation, and dysregulated behavior by resident myofibroblasts, culminating in the development of penetrating …
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Role of von Willebrand factor in shear induced platelet accumulation in a microfluidic device
Thrombus formation under high fluid shear rates at the site of atherosclerotic plaque rupture leads to myocardial infarction and stroke. At high shear rates, thrombus is formed by platelets adhering via the glycoprotein von Willebrand factor (vWF). To investigate the relative contributions of vWF …
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Venous Thrombosis: Formation, Evolution And Resolution Imaging Using Non-Invasive MRI Techniques
… treatment. Experimental data suggest that thrombus rich in fibrin has better response to thrombolysis than red cell rich (acute phase) or collagen rich (chronic) thrombus.Thus, there is a need for a diagnostic technique that provides better information on the stage of<br/>thrombus …
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Endovascular Optical Coherence Tomography Imaging in Cerebrovascular Disease
… injury occur after EVT, and residual luminal thrombus was present despite complete angiographic revascularization. Next, we designed a preclinical swine model of cerebral venous sinus thrombosis (CVST) with subsequent EVT and OCT imaging. OCT revealed that residual bridging cortical vein …
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Visualisation on blood flow mechanism of vein in deep vein thrombosis (DVT) study
… blood abnormality, for example the existence of thrombus. Proper blood flow in veins are important to ensure the effective return of deoxygenated blood to the heart. It is challenging to determine the vessel condition, due to the inability to visualize the thrombus presence in the vessel. This is …
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Label-Free Functional Imaging Of Platelets At Nanoscale
… is the key cellular machinery of a blood clot/thrombus. Platelet morphodynamics under fluid shear plays an essential role in the quantitative analysis of platelet dysfunction. The mechanical properties of platelets inform the formation of haemostatic plugs that have wide application in bleeding …
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Label-Free Functional Imaging Of Platelets At Nanoscale
… is the key cellular machinery of a blood clot/thrombus. Platelet morphodynamics under fluid shear plays an essential role in the quantitative analysis of platelet dysfunction. The mechanical properties of platelets inform the formation of haemostatic plugs that have wide application in bleeding …
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Multi-scale computational modeling of particle adhesion dynamics under shear flow
… to two different problems. In the application of thrombus simulation, a physical description of the von Willebrand factor (VWF) mediated thrombus growth process was formulated. The physics-based model captures distinct stages of the thrombus growth process in shear-induced platelet adhesion (SIPA) …
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Relato de caso: manejo anestésico de nefrectomia com trombectomia cavoatrial sob circulação extracorpórea
… its propensity for venous invasion, with tumor thrombus formation in the renal vein and extension into the inferior vena cava (IVC), observed in 4–10% of patients. Cases in which the thrombus extends to the right atrium (RA) are rarer, occurring in approximately 1% of patients, and require a …
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Effects of air pollution on vascular thrombosis
… endogenous fibrinolytic mechanisms that promote thrombus breakdown. The initial aims of this work were to develop an in vivo model of thrombosis, to determine whether exposure to DEP did alter clotting. Initial attempts to develop the Folts’ model (which stimulates thrombus formation via arterial …
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Bifunktionale Fusionsproteine : Kombination hochselektiver, direkter FXa Inhibition mit aktivationsspezifischer GP IIb/IIIa Blockade einerseits, und zielgerichtetem Fibrin-Targeting andereseits
… reichert sich lokal am fibrinreichen venösen Thrombus an. Die Fibrinspezifität erlaubt eine hohe TAP Konzentration am Thrombus und somit eine potente Faktor Xa Inhibition auf der Oberfläche des Gerinnsels bei gleichzeitig systemisch niedrigen Konzentrationen an Fusionsprotein. Wir konnten …
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