Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Thrombospondin-1"”.
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Investigating adipose tissue angiogenesis in obesity reveals a novel role for thrombospondin-1.
Obesity is a major health problem that has reached epidemic proportions worldwide.Therapeutic intervention for obesity has proven extremely challenging. Obesity is a complex trait involving the interaction of genes involved in fundamental aspects of weight maintenance, exposure to an environment …
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Differences in the regulation of Thrombospondin-1 expression between epithelial cells and fibroblasts
… cells repression of the angiogenesis inhibitor Thrombospondin-1 (Tsp-1) requires stimulation of Myc in combination with hyper-physiologic levels of oncogenic Ras. This work demonstrates that in human mammary epithelial cells, repression of Tsp-1 requires the activation of Myc by a Ras-induced …
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Contribution of the Microenvironment in Bone Resident Cancer: the Role of Thrombospondin-1 in Bone and Risk Loci Contributing to Multiple Myeloma
… Chapter 2 we discuss the role of bone-resident Thrombospondin-1 (TSP1), a glycoprotein with well-documented roles in promoting cancer growth. Chapter 3 is focused on the identification of genes conferring inherited susceptibility to multiple myeloma that participate both in malignant cells and …
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Platelet micro-particles induce angiogenesis through the delivery of the micro-RNA Let-7a into endothelial cells
… and migration, with a focus on the regulation of thrombospondin-1 release by platelet micro-particles delivered Let- 7a. The role of thrombospondin-1 receptors (integrin beta-1 and integrin associated protein) and downstream caspase-3 activation were explored by Let-7a inhibition prior to PMP …
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A plazma XIII-as faktor hatása a vaszkuláris simaizomsejtek funkcióira
… fokozódik, az anti-angiogén fehérjéké, mint a thrombospondin-1 (TSP-1) csökken. Munkánk során vizsgálni kívántuk a TSP-1 fehérje aktivált FXIII kezelés hatására bekövetkező változását elkülönülten a simaizomsejtek lizátumában és az extracelluláris mátrixban, valamint a FXIII-A hatását a …
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Untersuchungen zur antiangiogenen Aktivität des matrizellulären Proteins Thrombospondin-2
… von pro- und antiangiogenen Faktoren abhängig. Thrombospondin-2 (TSP-2) gehört zu den endogenen antiangiogenen Faktoren. TSP-2 hemmt das Tumorwachstum durch Hemmung der Gefäßneubildung, die für die Progression von Tumoren notwendig ist. Im Gegensatz zu dem strukturell verwandten …
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Glia Are Required For Sensory Neuron Morphology And Function In Caenorhabditis elegans
… gene, fig-1, that encodes a protein with thrombospondin type I domains. FIG-1 likely functions extracellularly, is essential for neuronal dye uptake, and also affects behavior. To characterize the molecular basis of cilia morphogenesis and function, we cloned the che-12 and dyf-11 mutants …
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The interaction of angiocidin and tissue transglutaminase
… chromatography using a peptide fragment of thrombospondin-1 (TSP-1), a matrix protein that has been implicated in mechanisms of tumor progression. The recombinant protein was expressed and shown to be a potential inhibitor of angiogenesis but the mechanism of action was not characterized. …
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Peptide inhibitors of angiogenesis in endometriosis and the female reproductive system
… we evaluated the effect of an anti-angiogenic thrombospondin-1 mimetic peptide, ABT-898, on angiogenesis of endometriotic lesions. ABT-898 inhibited endothelial cell proliferation and tube formation in vitro. Mice treated with ABT-898 showed reduced vascularity of endometriosis lesions compared …
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Microvascular Function and Remodeling Due to Chronic Changes Within the Skeletal Muscle Microenvironment
… endothelial growth factor-A (VEGF-A) and thrombospondin-1 (TSP-1). The objective of this dissertation was to examine how alterations to the microenvironment impacted the appropriate microvascular remodeling responses to alterations in flow. The skeletal muscle microenvironment was altered …
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Novel Mechanisms of Β-Adrenergic Signaling In Prostate Cancer Progression
… HDAC2 further suppresses the expression of thrombospondin 1 (TSP1) in order to induce angiogenesis, thus acting as a mediator for the β-adrenergic signaling pathway.</p> <p>Here, we have introduced two new pathways acting downstream of the ADRB2/CREB axis. We show that the CREB/GRK3 axis …
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Differentielle Genexpressionsanalyse aktivierter Endothelzellen
… Gene, darunter das Proteasom, Endothelin 1, Thrombospondin 1, Caveolin 1, Lipocortin 1, alpha-Gi sowie verschiedene Hitzeschockproteine. Für sämtliche neuen Gene wurden die Expressionsmuster in 8 verschiedenen Organgeweben und dem physiologischen Angiogenesemodell des weiblichen ovariellen …
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The Role of Dermal Architecture in Wound Healing and Tumour Differentiation
… proteins type 5 collagen alpha 1 (COL5A1) and thrombospondin 1 (TSP1) were upregulated in RDEBF and UVSCCF fibroblasts, and further upregulated in RDEBSCCF fibroblasts (Ng, Pourreyron et al. 2012).<br/><br/>Following these observations, the work done in this thesis attempts to further elucidate …
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Analysis of the function and subcellular localization of FAT/CD36 in hepatocytes and transfected cell lines of hepatic and non-hepatic origin.
… to adhesion of platelets via its binding to thrombospondin-1. In monocytes and macrophages, it contributes to recognition and phagocytosis of apoptotic cells and it mediates the binding and uptake of oxidatively damaged low-density lipoproteins (oxLDL). In adipose and muscle tissues, FAT/CD36 …