Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Thrombospondin"”.
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Untersuchungen zur antiangiogenen Aktivität des matrizellulären Proteins Thrombospondin-2
… von pro- und antiangiogenen Faktoren abhängig. Thrombospondin-2 (TSP-2) gehört zu den endogenen antiangiogenen Faktoren. TSP-2 hemmt das Tumorwachstum durch Hemmung der Gefäßneubildung, die für die Progression von Tumoren notwendig ist. Im Gegensatz zu dem strukturell verwandten …
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Investigating adipose tissue angiogenesis in obesity reveals a novel role for thrombospondin-1.
Obesity is a major health problem that has reached epidemic proportions worldwide.Therapeutic intervention for obesity has proven extremely challenging. Obesity is a complex trait involving the interaction of genes involved in fundamental aspects of weight maintenance, exposure to an environment …
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Differences in the regulation of Thrombospondin-1 expression between epithelial cells and fibroblasts
… cells repression of the angiogenesis inhibitor Thrombospondin-1 (Tsp-1) requires stimulation of Myc in combination with hyper-physiologic levels of oncogenic Ras. This work demonstrates that in human mammary epithelial cells, repression of Tsp-1 requires the activation of Myc by a Ras-induced …
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Uncovering the role of a Cryptosporidium parvum thrombospondin protein (CpTSP8) in host cell attachment
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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The role of A Disintegrin and Metalloproteinase with Thrombospondin Motifs-‐15 (ADAMTS-‐15) in Breast Cancer
… the A Disintegrin and Metalloproteinase with thrombospondin motifs (ADAMTS) family are candidate tumour suppressors, including ADAMTS-15. In the context of breast cancer relatively high levels of ADAMTS-15 expression had previously been associated with increased relapse free survival. However …
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Contribution of the Microenvironment in Bone Resident Cancer: the Role of Thrombospondin-1 in Bone and Risk Loci Contributing to Multiple Myeloma
… Chapter 2 we discuss the role of bone-resident Thrombospondin-1 (TSP1), a glycoprotein with well-documented roles in promoting cancer growth. Chapter 3 is focused on the identification of genes conferring inherited susceptibility to multiple myeloma that participate both in malignant cells and …
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Platelet micro-particles induce angiogenesis through the delivery of the micro-RNA Let-7a into endothelial cells
… and migration, with a focus on the regulation of thrombospondin-1 release by platelet micro-particles delivered Let- 7a. The role of thrombospondin-1 receptors (integrin beta-1 and integrin associated protein) and downstream caspase-3 activation were explored by Let-7a inhibition prior to PMP …
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Investigation of the effects of Mechanical Strain in Human Tenocytes
… RGD, Mannose-6-phosphate, integrin β1 and a thrombospondin as appropriate. qRT-PCR and a cell based luciferase assay were used to assess RNA and TGFβ activity respectively. The prolonged application of 5% cyclic mechanical strain in a 3D culture system induced an anabolic response in protease …
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Glia Are Required For Sensory Neuron Morphology And Function In Caenorhabditis elegans
… gene, fig-1, that encodes a protein with thrombospondin type I domains. FIG-1 likely functions extracellularly, is essential for neuronal dye uptake, and also affects behavior. To characterize the molecular basis of cilia morphogenesis and function, we cloned the che-12 and dyf-11 mutants …
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A plazma XIII-as faktor hatása a vaszkuláris simaizomsejtek funkcióira
… fokozódik, az anti-angiogén fehérjéké, mint a thrombospondin-1 (TSP-1) csökken. Munkánk során vizsgálni kívántuk a TSP-1 fehérje aktivált FXIII kezelés hatására bekövetkező változását elkülönülten a simaizomsejtek lizátumában és az extracelluláris mátrixban, valamint a FXIII-A hatását a …
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The role of von Willebrand factor and its cleaving protease, ADAMTS13, in young patients with HIV-related stroke.
… of A Disintegrin and Metalloproteinase with a Thrombospondin type 1 motif, member 13 (ADAMTS13), the protease that cleaves ultra large VWF multimers into smaller less haemostatically active multimers, have been associated with an increased propensity for thrombosis. Stroke is a potential …
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Cartilage oligomeric matrix protein in der Pathogenese der Arthrosis deformans
Als ein Mitglied der Thrombospondin-Gen-Familie, ist das Cartilage oligomeric matrix protein (COMP) hauptsächlich in der extrazellulären Matrix zu finden. Eine häufige Bindung an Knorpel konnte bereits nachgewiesen werten. Weiter ist COMP in Synovialflüssigkeiten und dem Bandhalteapparat …
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A genome-wide association study in chronic thromboembolic pulmonary hypertension and the ADAMTS13-VWF axis
… (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13). The ADAMTS13-VWF axis was investigated in 208 CTEPH patients including its relationship to ABO blood groups and ADAMTS13 genetic variants. Plasma ADAMTS13 levels are markedly reduced in CTEPH. This is …
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The agarase system of saccharophagus degradans strain 2-40 : analysis of the agarase system and protein localization
… binding modules. Furthermore, AgaE contains four thrombospondin type-three repeats whose function in prokaryotic proteins were unknown. The predicted agarases were characterized using a variety of methods including genomics, biochemical assays, proteomics and a newly described mutagenic technique. …
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Selecting dietary-derived bioactives which protect cartilage from destruction in osteoarthritis
… a disintegrin and metalloproteinase domain with thrombospondin motifs, ADAMTSs) play an important role in cartilage degradation. The collagenases (MMP-1 and MMP-13) and aggrecanases (ADAMTS-4 and ADAMTS-5) are implicated in the development of OA because of their ability to degrade type 2 collagen …
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ADAMTS13 Activity in Dogs with Chronic Enteropathies
… of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13), a von Willebrand factor (vWF) cleaving enzyme, and increased circulating vWF. The primary aim of this study is to assess plasma ADAMTS13 activity, vWF antigen (vWF:Ag) concentration, and vWF …
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The interaction of angiocidin and tissue transglutaminase
… chromatography using a peptide fragment of thrombospondin-1 (TSP-1), a matrix protein that has been implicated in mechanisms of tumor progression. The recombinant protein was expressed and shown to be a potential inhibitor of angiogenesis but the mechanism of action was not characterized. …
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Peptide inhibitors of angiogenesis in endometriosis and the female reproductive system
… we evaluated the effect of an anti-angiogenic thrombospondin-1 mimetic peptide, ABT-898, on angiogenesis of endometriotic lesions. ABT-898 inhibited endothelial cell proliferation and tube formation in vitro. Mice treated with ABT-898 showed reduced vascularity of endometriosis lesions compared …
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Microvascular Function and Remodeling Due to Chronic Changes Within the Skeletal Muscle Microenvironment
… endothelial growth factor-A (VEGF-A) and thrombospondin-1 (TSP-1). The objective of this dissertation was to examine how alterations to the microenvironment impacted the appropriate microvascular remodeling responses to alterations in flow. The skeletal muscle microenvironment was altered …
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