Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Thrombin receptor"”.
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Identification of a vascular smooth muscle cell transition associated with fibrous cap formation and induced by thrombin receptor activation
… plaques. From this, protease-activated receptor-1 (PAR1) emerged as a candidate regulator of fcVSMC generation. PAR1 was expressed in VSMCs within the fibrous caps of human plaques and its activation by thrombin in cultured human VSMCs induced expression of contractile, ECM and other …
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Characterisation of protease activated receptors
The thrombin receptor is a seven transmembrane G-protein-coupled receptor that is activated by thrombin cleavage. In order to characterise the thrombin receptor three mouse monoclonal antibodies were isolated by using a recombinant fusion protein incorporating the extracellular domain of the human …
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Characterization of cathepsin B cysteine protease from Naegleria fowleri excretory-secretory proteins exerting immunomodulatory effects
… phospholipase, proteases, peroxiredoxins and thrombin receptor. However, the precise mechanism induced by Nf-ESPs in PAM is not fully understood yet. In this study, the cytopathic changes and inflammatory responses induced by Nf-ESPs were analyzed in BV2 microglial cells. Several cytokines, …
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The Tetraspanin CD9 Localizes to Platelet-Platelet Contacts and Regulates Thrombus Stability
… crosslinking CD9 with the platelet FcγRII receptor. Confocal analysis of platelet spreading indicated that CD9 perturbation by mFab7 resulted in increased platelet spreading on a variety of matrices, although platelet adhesion was unaffected on all matrices except fibrin. Platelet-platelet …
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Recurrent unexplained first-trimester miscarriage. Effects of acetylcalicylic acid, platelet aggregation and thyroid disease
… induced by AA, adenosine diphosphate (ADP), thrombin receptor activating peptide 6 (TRAP) and collagen (COL) were determined four times during pregnancy and three months postpartum. From the randomized population, 176 and 177 women, respectively, with normal AA-induced platelet aggregation …
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An investigation of the role of ACTN1 in platelet formation and of platelet function in myeloma
… to agonist [adenosine diphosphate (ADP), thrombin receptor-activating peptide 6] stimulation in-vitro was observed, with significantly reduced surface levels of P-selectin in response to ADP in patients with MGUS. Platelet-associated immunoglobulins were elevated in a subset of patients. A …
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Ο ρόλος της θρομβίνης και των υποδοχέων της στην αγγειογένεση και στην ανάπτυξη και μετάσταση του καρκίνου
Απο τις απαρχές της μελέτης του PAR1, είχε βρεθεί οτι βρίσκεται σε στενή συνάφεια με τον καρκίνο, με ποικιλία πειραμάτων που έγιναν σε καρκινικές σειρές και σε διάφορα πειραματικά μοντέλα ζώων. Οι σκοποί της παρούσας εργασίας μπορούν να συνοψιστούν ως εξης: Η διερεύνηση της έκφρασης του υποδοχέα 1 …