Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Thrombin binding aptamer"”.
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Optimizing Acyclic Identification of Aptamers
<p>The minimal human alpha-thrombin binding aptamer, d(GGTTGGTGTGGTTGG), has previously been successfully identified from a DNA library of randomized hairpin loop, m=15, with the High Throughput Screening of Aptamers (HTSA) technique, later termed Acyclic Identification of Aptamers (AIA). AIA …
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Application of silicon photonic microring resonators to the study of surface bioconjugation and protein capture agent binding kinetics
… recently utilized for monitoring biomolecular binding and detection in an array-based, label-free biosensor format. First, aniline-catalyzed hydrazone ligation between surface immobilized hydrazines and aldehyde-modified antibodies is shown to be an efficient method to functionalize model …
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Control of blood clotting using gold nanorods
… clotting by releasing a single stranded (ssDNA) thrombin binding aptamer (TBA) upon laser irradiation. It is possible to control blood clotting by releasing TBA that binds and inhibits thrombin, and an antidote consisting of a complementary ssDNA sequence that binds to TBA and restores thrombin …
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Two-dimensional infrared spectroscopy of nucleic acids : application to tautomerism and DNA aptamer unfolding dynamics
… used to characterize the structural dynamics of thrombin-binding aptamer (TBA), which is a 15mer DNA folded into a guanine-quadruplex (G-quadruplex). The 2D IR spectral signatures of G-quadruplex were established, and T-jump transient 2D IR was employed to investigate the unfolding dynamics of …
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High Throughput Screening of Aptamers
<p>Aptamers are functional oligonucleotides that are discovered through directed evolution. With affinities for their targets similar to antibodies, aptamers are useful in biosensors, diagnostics and therapeutics. Three elements of natural selection--variation, selection, and replication afford …