Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Three-dimensional cell culture"”.
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A self-assembling peptide scaffold functionalized for use with neural stem cells
… used synthetic materials employed in the culture of neural stem cells. Furthermore, improvements in the performance of RADA16 have recently been made by appending the self-assembling peptide sequence with various functional motifs from naturally occurring proteins. The focus of this work …
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Use of fourier transform- infrared spectroscopic imaging as a tool for understanding early molecular events driving breast cancer progression
… well-documented phenomenon. Fibroblasts are the cell type responsible for maintaining the stroma, and cancer-associated fibroblasts, characterized by the expression of α-smooth muscle actin (α-SMA) protein, are highly contractile compared with those found in normal tissue. Although the fibroblast …
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Tissue-Specific Matrix Control of Cell Cohesion and Migration Signaling Complexes
<p>The extracellular matrix (ECM) is a complex, interconnected network of three major constituents: collagens, glycoproteins, and proteoglycans, along with their enzyme modifiers. Within this network and beyond the structural role, each ECM molecule contributes a context-specific signal that …
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Decellularized Apium graveolens Scaffold for Cell Culture and Guided Alignment of C2C12 Murine Myoblast
… of meat production. To date, the expansion of cellular agriculture is believed to be dependent on four pillars: animal free scaffolds, serum free media, bioreactors and cell lines or stem cells. In 2014, decellularized plant tissue emerged as an animal free scaffold for three-dimensional cell …
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Host-Pathogen Interactions at the Intestinal Epithelial Barrier
… the intestinal epithelial barrier and the intracellular apicomplexan Eimeria spp., both in vivo and in vitro. Initially, conventional in vivo studies using genetically modified animals were used to investigate the contribution of innate lymphoid cells (ILCs) to immune protection of the …
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Microfluidics for Cell Culture and Single Cell Assays
Elucidating molecular processes that govern cell function is paramount in forming a basis for understanding human health and treating disease. Research is presently limited by investigating in bulk, where information on critical subsets of cells is lost through averaging across an entire …
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Development of microcantilever mid-infrared detectors and sources and their application in infrared spectroscopy
… this study introduces the integration of one-dimensional high-contrast grating into silicon-aluminum bimaterial cantilevers which enhances the amplitude and bandwidth of the IR absorbance as well as the responsivity. With the integrated grating, the silicon layer acts as a grating coupler and …
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Systems pathology: a bottom-up approach for understanding fibroblast-epithelial interactions in breast cancer
… interaction with fibroblasts, the predominant cell type found in the breast tumor stroma, is a critical regulatory step in the progression of breast cancer from confined to invasive disease. Hence, we developed a novel three-dimensional co-culture model to investigate this interaction. The …
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Development of a gene therapy approach for the treatment of human mammary carcinoma using tissue specific retroviral vectors
… In order to specifically target malignant cells while at the same time sparing normal tissue, cancer gene therapy will need to combine highly selective delivery with highly specific gene expression, specific gene product activity and, possibly, specific drug activation. Use of cell type or …