Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 46 for “"Three cell lines"”.
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Chemosensory Evaluation of Prostate Cancer Cells
… nose to discriminate between prostate cancer cells (DU-145 and PC-3) and non-tumor forming cells from the urinary tract (SVHUC). Specific factors that will be investigated are incubation period and cell population. For all three cell lines, two cell populations of 75,000 and 150,000 cells were …
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X chromosome studies and breast and ovarian carcinoma
… expression, and methylation in 8 ovarian cancer cell lines. Another marker of an X reactivation event, skewed XCI, was assayed in peripheral blood DNA from 106 breast and/or ovarian cancer patients (52 BRCA1 mutation carriers, 24 BRCA2 mutation carriers, 30 non-mutation carriers), 147 age-matched …
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IDENTIFICATION OF HCMV UL97 IN GBM CELL LINES AND A POSSIBLE ROLE FOR GANCICLOVIR
… Cytomegalovirus (HCMV) was identified in GBM cells, and has been a topic of debate concerning its role with tumor progression. This study used three established GBM cell lines; T98, LN229, and U87 in order to identify and examine the presence of HCMV phosphotransferase protein UL97. Reverse …
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The role of FGF growth factors in the development of chemotherapy drug resistance in ovarian cancer cells.
… in ovarian cancer. Previous work developed three resistant cell lines from the A2780 ovarian cancer cell line (A2780CBN, A2780DXL, A2780CBNDXL), In the previous studies, microarray analysis was performed to find changes in gene expression in the three cell lines. We have been able to confirm …
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Biomarkers of oxidative stress in models of schizophrenia.
… comparative studies using a lymphoblastoid cell line of schizophrenic origin, a neuroblastoma IMR-32 cell line and the lymphoma U937 cell line. For the three cell lines, the study assessed the cytoprotective effects of phenolic antioxidants and essential fatty acids in affording protection …
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Diagnostic Neuropathology of Brain Tumours using Biophotonics and Spectrometry
… infrared (ATR-FTIR) looking at brain tumour cell lines. This study investigated the potential application of vibrational spectroscopy in the segregation of different types of brain tumours using two tumour cell lines, U87MG, 1321N1 and a control, SVGP12. Another study looked at two …
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Molecular mechanisms of cadmium toxic
… evidence about its mechanism(s) of action in the cells. The present study was therefore undertaken with the aim of defining the role of oxidative stress, intracellular Ca²⁺ alteration via phospholipase C- Inositol-1,4,5-triphosphate (PLC-IP3) and mitochondrial-cytochrome c dependent pathways in …
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The role of potential antioxidant in medicinal drug-induced oxidative stress
… partially due to its antioxidant potential. Cell-free studies were conducted for reducing power, radical-scavenging power and metal-chelating capacity of SF extract, as well as in-vitro study for its possible protective role against exogenous oxidative stress in three cell lines. Positive …
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Investigation of aspects of reactive gliosis in human astrocytoma cell lines:application for toxicity assessment
… to the human response than existing animal cell based models, the U251-MG, U373-MG and CCF-STTG 1 human astrocytoma cell lines were investigated for their ability to exhibit reactive-like changes following exposure to ethanol, chloroquine diphosphate, trimethyltin chloride and acrylamide. …
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Molecular mechanisms of drug resistance, invasion and metastasis in pancreatic carcinoma
… in pancreatic cancer involved pulse-selection of three cell lines with epirubicin, taxotere and gemcitabine. The drug-selected cell lines, in general, displayed low changes in sensitivity to their respective selecting drugs and no obvious cross-resistance profile. However, drug treatment modulated …
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Pi3K- and Mtor-Dependent Mechanisms of Lapatinib Resistance and Resulting Therapeutic Opportunities
… establish lapatinib resistance models we treated three HER2+ breast cancer cell lines with lapatinib for several months until they became lapatinib-resistant. We then compared lapatinib-sensitive (parental) cells with their lapatinib-resistant (LapR) counterparts to identify changes conferring …
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Novel non-viral delivery systems for cancer gene therapy
… is an attractive tool to improve specificity and cellular uptake of carriers, and surface modification of dendrimers with hydrophilic polymers such as polyethylene glycol should facilitate lower systemic toxicity and promote the enhanced permeability and retention (EPR) effect, which should result …
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GPR55 and N-acyl Amino Acids
… these novel lipids as potential GPR55 ligands. Three cell lines were utilised, a stably transfected HEK293 cell line that overexpresses 3xHA N-terminus tagged hGPR55 (hGPR55-HEK293 cells) and control HEK293 cells. In addition, the DU145 a prostate cancer cell line which is reported to …
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The Role of Immunological Receptors CD74 and CD44 in Association with the Macrophage Migration Inhibitory Factor (MIF) on Human Breast Cancer Derived Cells
… receptors has been linked to signalling, cell communication and tumour progression. This study has shown that cluster of differentiation (CD) 74 and CD44 act in synergy and are susceptible to the effect of the macrophage migration inhibitory factor (MIF). MIF is a 12.5 kDa chemokine-like …
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Investigating the Heterogeneity of Tumor Associated Macrophages in Human Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a liver cancer and is one of the leading causes of cancer death worldwide. Despite significant efforts in treating HCC, such as with the use of novel immune checkpoint inhibitors, the overall response rate remains low. This may be partly attributed to the lack of a …
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Il-2 Regulation of Il-24 Expression Leads to Growth Suppression of Melanoma Cells
… mediated tumor growth suppression. Five melanoma cell lines were treated with high dose recombinant hIL-2 at 1000U/ml. Three of the cell lines (A375, WM1341, WM793) showed statistically significant increases in their levels of IL-24 protein when measured by Western blotting, while the remaining …
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Enhancing Oncolytic Virotherapy Using Functional Genomic Screening
… We conducted human genome-wide RNAi screens in three tumour cell lines and identified 237 genes that upon silencing enhanced spread in two out of the three cells lines tested and 23 across all three cell lines. Muscle RAS oncogene homolog (MRAS) emerged as a promising candidate following in …
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Pathogenic mechanisms of Photobacterium damselae subspecies piscicida in hybrid striped bass
… catfish ovary (CCO), and fathead minnow (FHM) cells lines was also evaluated using an in vitro invasion assay. All three cell lines were susceptible to invasion and supported replication of P. damselae. Fathead minnow cells were more susceptible to invasion than the other two cell lines as …
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Differenziamento macrofagico: gli effetti dei polimeri sintetici
… and the effect of their interaction with cells, in particular with the cell populations involved in the inflammatory responses, i.e. monocyte/macrophages. In consideration of what above said, the aim of this study is the comprehension of the in vitro effect of PAI, PVA and PU on three cell …
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Liposome-Mediated DNA Transfer
… pressure to increase transfection efficiency in cell lines as a potential way to produce transgenics through embryonic stem cells. The second method used artificial insemination with liposome-treated sperm in an effort to produce transgenic animals. The effects of high pressure on cell viability …
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