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Showing 1 to 6 of 6 for “"Three Component Coupling"”.
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The Multicomponent Synthesis of Pyrroles from Cylcopropane S Using a One Pot Pd(0) Catalyzed Dehydrocarbonylation Protocol
… can be efficiently synthesized using a three component coupling reaction between a hydroxylamine, aldehyde and cyclopropane diester. This affords the desired heterocycle efficiently with a wide variety of substitution. When one esters bears an allyl group a Tsuji dehydrocarbonylation …
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Nucleophilic Carbon-Carbon Bond-Forming Reactions of 2-Methylenetetrahydropyrans
… their nucleophilic nature. This work provides three general methods toward the synthesis of 2-β-oxygenated pyranyl substrates, which are key structural components of many biologically active polyketides and natural products.</p> <p>The use of exocyclic enol ethers as nucleophiles was first …
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New Strategies and Transformations for the alpha-Functionalization of Amines to Access Chiral Amines
… focus on the research exploration of three synthons: 2-azaallyl anion, 2-azaaalyl radical and 2-azadiene. </p><p> We began investigating processes to access alpha-amino anions directly through alpha-deprotonation of imines (formation of 2-azaallyl anions). The alpha-amino anion was …
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Iridium-Catalyzed Enantioselective Allylation of Alkenyl Boronates
… enantioselectivity and 1,3-diastereocontrol. The three-component coupling features an Ir(phosphoramidite) complex, which catalyzes a kinetic resolution of secondary allylic carbonates. Alkenyl boronate addition to an Ir(π-allyl) intermediate and a 1,2-metalate shift provides the observed products. …
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Synthesis of Sulfonyl Fluorides and the Total Synthesis of the Rhodocorane Natural Products
… oxidizing organophotocatalyst, which undergoes a three-component coupling with a sulfur dioxide source and a fluorine source. The challenges associated with this methodology along with photophysical measurements and evidence for the mechanism are discussed. In the fourth chapter, we discuss our …
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Oxidative Heck Reactions with Terminal Olefins
… group tolerance and mild conditions of this three-component coupling reaction provide an attractive manifold for the rapid build-up of dense functionality around terminal olefins with minimal protecting group strategies or undesirable oxidation/reduction reactions.The synthetic utility of …