Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"Thoracic aortic aneurysm"”.
-
Mechanical Effects of Surgical Adhesives on Ascending Thoracic Aortic Aneurysm Replacement
<p>Ascending thoracic aortic aneurysm (aTAA) is a potentially lethal disease which grows gradually over time and may lead to aortic dissection and rupture. Currently, aTAA surgical repair using Dacron graft is a well-established treatment. In addition, surgical adhesives are frequently used in the …
-
Predicting the risk of progression in patients with thoracic aortic aneurysm
… biomarkers in a cohort of 50 patients with aneurysms of the arch and descending thoracic aorta. I have described within this thesis various obstacles (logistical and biological) to identifying biomarkers of aneurysm progression. Despite these challenges, I have created a unique dataset …
-
Identification of in vivo material properties of ascending thoracic aortic aneurysm: towards noninvasive risk assessment
… for biomechanical risk assessment of ascending thoracic aortic aneurysm (ATAA). A novel inverse method was developed for in vivo hyperleastic property identification from clinical 3D CT image data. The developed inverse approach was validated by using numerical examples as well as clinical CT …
-
Lineage-Specific Phenotypic Abnormalities in iPSC-Derived Smooth Muscle Cells from Type-I Loeys-Dietz Syndrome
… the risk of developing a potentially fatal thoracic aortic aneurysm (TAA) and dissection, yet the mechanisms underlying TAA development remain unclear. In LDS, TAAs frequently develop at the aortic root, where smooth muscle cells (SMCs) from two distinct embryonic origins – the lateral …
-
Pharmacologic and Genetic Manipulations of Angiotensin Signaling In Thoracic Aortic Disease Models
<p>Thoracic aortic aneurysms and dissections (TAAD) are a major cause of morbidity and mortality in patients. Many different risk factors have been associated TAAD, but hypertension is the largest risk factor. Subsets of TAAD patients have identifiable syndromic genetic diseases, yet a number of …
-
A Novel Multiblock Immersed Boundary Method Enabling High Order Large Eddy Simulation Of Pathological And Medical Device Hemodynamics
… laminar and transitional flow in an abdominal aortic aneurysm (AAA), transitional flow in a model stenosed artery, and turbulent flow in a mixing layer are used as benchmark cases for validating the solver thoroughly.</p> <p>WenoHemo is then applied to study blood flow patterns in a …
-
Imaging microcalcium in thoracic aortic disease
BACKGROUND: Disease of the thoracic aorta occurs in two major forms; atheroma and aneurysm formation. Both disease processes progress silently before catastrophic complications occur, such as stroke or aortic dissection. Current management strategies focus on preventative interventions which can …