Global ETD Search
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Showing 1 to 11 of 11 for “"Thiosemicarbazones"”.
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Multinuclear PGM complexes of thiosemicarbazones : synthesis, characterisation and biological activity
A series of mono- and dithiosemicarbazone ligands were prepared by simple Schiff-base condensation reactions between thiosemicarbazides and various substituted salicylaldehydes.
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Mono- and multinuclear PGM complexes containing thiosemicarbazones synthesis, characterization and antiplasmodial evaluation
Four aryl- and ferrocenyl-derived thiosemicarbazone ligands have been synthesized and characterized using NMR, infrared (IR) spectroscopy and mass spectrometry. These ligands were used towards the synthesis of three series of mono- and multinuclear complexes, in which the thiosemicarbazone ligands …
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Synthesis and biological evaluation of antiparasitic Cysteine protease inhibitors based on the Isatin Scaffold
… acyl or sulfonyl halide. A series of isatin-3-thiosemicarbazones were prepared by condensation of isatin I substituted isatins with thiosemicarbazide, and also a series of isatin-based Schiff and Mannich bases were prepared by reacting selected isatin-3-thiosemicarbazones with formaldehyde and …
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Investigation of the efficacy of identified acetolactate synthase inhibitors, peptidyl cysteine protease inhibitors, thiolactomycins, and thiosemicarbazone compounds against Mycobacterium tuberculosis
… inhibitors, cysteine protease inhibitors, thiosemicarbazones, and thiolactomycins classes of compounds for in vitro efficacy against M. tuberculosis using the resazurin microtitre plate assay afterwhich active compounds were assessed for cytotoxicity in vitro against elicited peritoneal …
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Biospeciation, Interaction with Biomolecules and Mechanism of Action of Potential Cu and V Drugs
… phenanthroline derivatives, pyridinones, thiosemicarbazones, hydrazones, and 8-hydroxyquinoline, was employed to explore the structural diversity of these systems. The interactions of these metal complexes with proteins such as myoglobin, ubiquitin, lysozyme, cytochrome c, ribonuclease A, …
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Ferrocenic metal chelators : synthesis, biological and electrochemical studies
… evaluation. All the N-substituted ferrocenic thiosemicarbazones were evaluated against a chloroquine resistant W2 strain of the malaria parasite P. falciparum and enzymes (falcipains 2 & 3) derived from the same parasite. The intermediate thiosemicarbazone thioesters were also tested against …
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Synthesis and Antimalarial evaluation of Gold Thiosemicarbazone Complexes and Polyamine-Thiosemicarbazone Dendrimers
… presents research investigating a series of thiosemicarbazones (TSCs) and their novel gold complexes and dendrimers as potential antimalarial agents. A series of TSCs were synthesised in one step using Schiff base chemistry. On the other hand pyrazoline analogues were obtained in two steps …
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Inhibitors of human cathepsin L and cruzain as therapeutic agents.
… inhibitors of cathepsin L: the benzophenone thiosemicarbazones 2 (IC50= 1.5 nM), 55 (IC50= 44 nM), 38 (IC50= 60 nM), 32 (IC50= 66 nM), and 37 (IC50= 140 nM) and a sulfone analog of the bromo substituted thiochroman-4-one 22 (IC50= 1 nM). Kinetics studies were used to gain understanding in …
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Growth and chemical functionalization of SiC nanowires for biomedical applications in cardiology and oncology
… and greater selectivity for the cancer cells. Thiosemicarbazones (TSCs) are Schiff bases which in recent years have attracted considerable attention thanks to their promising anticancer properties. These compounds are very active also in the fight against malaria, moreover they are used as …
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The characterization of pharmacokinetic properties and evaluation of in vitro drug combination efficacies of novel antimalarial compounds
… and redox active phenothiazines, phenoxazines, thiosemicarbazones, and quinolone derivatives were screened for antimalarial activity and mammalian toxicity. These were found to be potently active (11 μM) to Chinese Hamster ovarian (CHO) cells. The compounds are thus highly selective for P. …
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[3+2]-Cycloadditions of Azomethine Imines and Ynolates and Progress Towards a Radical Three-Component Cross-Coupling Reaction
This manuscript consists of three chapters. The first chapter describes a novel [3+2]-cycloaddition of azomethine imines and ynolates to construct bicyclic pyrazolidinones in high yields and diastereoselectivities. This methodology is the first example in which the azomethine imine acts as a chiral …