Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Thiosemicarbazone"”.
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Synthesis and Antimalarial evaluation of Gold Thiosemicarbazone Complexes and Polyamine-Thiosemicarbazone Dendrimers
… presents research investigating a series of thiosemicarbazones (TSCs) and their novel gold complexes and dendrimers as potential antimalarial agents. A series of TSCs were synthesised in one step using Schiff base chemistry. On the other hand pyrazoline analogues were obtained in two steps …
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64Cu-bis(thiosemicarbazone) complexes for delineating myocardial hypoxia
… of a range of cardiovascular diseases. Bisthiosemicarbazone (BTSC) ligands readily chelate positron emitting copper isotopes, and have been demonstrated to selectively accumulate in hypoxic tissue in vitro, in vivo, and in isolated perfused hearts. While the lead compound Cu-ATSM has been …
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64^Cu-bis(thiosemicarbazone) Complexes for Delineating Myocardial Hypoxia
… of a range of cardiovascular diseases. Bisthiosemicarbazone (BTSC) ligands readily chelate positron emitting copper isotopes, and have been demonstrated to selectively accumulate in hypoxic tissue in vitro, in vivo, and in isolated perfused hearts. While the lead compound Cu-ATSM has been …
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Thiosemicarbazone, xanthate and dithiocarbamate single source precursors for cadmium, lead and indium sulfide nanoparticles
… In the second chapter, eight CdX2 (X = Clˉ, Iˉ) thiosemicarbazone complexes were prepared and subsequently evaluated as single source molecular precursors towards the fabrication of oleylamine-capped CdS nanoparticles through a solvent thermolysis route. Various reaction parameters were explored …
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Chemical, Biological, and Preliminary In Vitro Studies of Novel Vanadium(IV) Complexes with Schiff Bases and Thiosemicarbazone Ligands
<p>9-Anthraldehyde-N(4)-methylthiosemicarbazone (MeATSC), potassium (E)-2-(2-hydroxybenzylideneamino)-3-(1H-indol-3-yl)propanoate (K[(Sal-<em>L</em>-tryp)] and 2-(2-hydroxybenzylamino)-3-(1H-indol-3-yl)propanoic acid (the reduced Schiff base) were prepared using known synthetic procedures. Two …
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Investigation of the efficacy of identified acetolactate synthase inhibitors, peptidyl cysteine protease inhibitors, thiolactomycins, and thiosemicarbazone compounds against Mycobacterium tuberculosis
… inhibitors, cysteine protease inhibitors, thiosemicarbazones, and thiolactomycins classes of compounds for in vitro efficacy against M. tuberculosis using the resazurin microtitre plate assay afterwhich active compounds were assessed for cytotoxicity in vitro against elicited peritoneal …
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Mono- and multinuclear PGM complexes containing thiosemicarbazones synthesis, characterization and antiplasmodial evaluation
Four aryl- and ferrocenyl-derived thiosemicarbazone ligands have been synthesized and characterized using NMR, infrared (IR) spectroscopy and mass spectrometry. These ligands were used towards the synthesis of three series of mono- and multinuclear complexes, in which the thiosemicarbazone ligands …
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Ferrocenic metal chelators : synthesis, biological and electrochemical studies
… chelators were designed and synthesized based on thiosemicarbazone and/or ferrocenyl moieties. The novel compounds were characterized by NMR, infrared (IR) and mass spectroscopy as well as microanalysis and subjected to biological evaluation. All the N-substituted ferrocenic thiosemicarbazones …
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Synthesis, characterization, biological and catalytic studies of tridentate monothiosemicarbazone palladium (II) complexes
Nine monothiosemicarbazone ligands were prepared by Schiff-base condensation reactions of thiosemicarbazide and the appropriate aryl aldehyde or ketone. These compounds were isolated as air- and moisture- stable solids and were characterized using NMR and IR spectroscopies, as well as mass …
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Development of organosilane-containing bioorganometallic compounds evaluated as antiparasitic agents against Plasmodium falciparum and Trichomonas vaginalis
… organosilane-containing compounds based on thiosemicarbazone (TSC),quinoline and benzothiazole scaffolds. Selected thiosemicarbazone-containing ruthenium(II), rhodium(III) and palladium(II) metal complexes were also studied. The compounds were screened for antiplasmodial and antitrichomonal …
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Inhibitors of human cathepsin L and cruzain as therapeutic agents.
… infection. A library of 59 small non-peptidic thiosemicarbazone and α, β-unsaturated carbonyl derivatives of benzophenone, propiophenone, α- and β-tetralone, 4-chromanone, and 4-thiochromenone were evaluated as inhibitors of human cathepsin L. While most of the compounds had IC50 values in the …
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Capacidad coordinante de ligandos derivados de 2-tiazolina e hidrazona frente a iones metálicos de transición
… azine (ATHTd), (2-acetyl-2-thiazoline) thiosemicarbazone (HATtsc), (2-acetyl-2-thiazoline) semicarbazone (ATsc) and (2-acetyl-2- thiazoline) acetylhidrazone (ATHAc) and of their metallic complexes with Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) have been realized.
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The synthesis and study of multimetallic Platinum Group Metal complexes as in vitro phamacological agents
… containing ligand, 3,4-dichloroacetophenonethiosemicarbazone, which has demonstrated in vitro pharmacological activity. This ligand was reacted with K2[PtCl4] to afford a tetranuclear cycloplatinated thiosemicarbazone complex (2.2). Reaction of 2.2 with different mono- and diphosphanes …
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Antiprotozoal quinolines containing electrophilic moieties
… scaffolds to which electrophilic groups, such as thiosemicarbazone, a,β-unsaturated ketone and pyrazoline moieties were appended.
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Studies on semiconductor nanoparticles and polymer nanocomposites
… -carboxypropionyl)thiosemicarbazide; Glyoxalbis(thiosemicarbazone); 2,6-Diacetylpyridine bis(thiosemicarbazone); Zinc(H) complexes of: Ethylxanthicacid; N,N' -dioctyl thiourea; N.N; -bis(thiocarbamoyl)hydrazine The second part of the project involves the synthesis, characterisation and …
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New aminoquinoline antimalarial cysteine protease inhibitors based on the isatin natural product scaffold
… in the design of these isatin derivatives is the thiosemicarbazone moiety previously demonstrated to inhibit cysteine proteases from mUltiple protozoan parasites. Synthesized compounds were tested against the enzyme falcipain-2 (Rec-FP-2) as well as the parasite source of this protease, Plasmodium …
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Design, synthesis, and biological evaluation of dihydronaphthalene and chalcone-based anticancer agents inspired by the natural product combretastatin A-4.
… selectivity of cathepsin L mediated cleavage of thiosemicarbazone and dipeptide drug-linker conjugates. The synthesis of dipeptide linkers along with thiosemicarbazone intermediates has contributed to our preliminary investigation of cathepsin L selectivity. These, and other, selective targeting …
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Mono- and polynuclear Ferrocenyl-derived complexes: synthesis, characterisation and biological evaluation as antimycobacterial and antiplasmodial agents
… complexes was also prepared incorporating a thiosemicarbazone moiety, as this is a known pharmacophore and may confer favourable properties in terms of biological activity as well as solubility. Methyl hydrazinecarbodithioate was synthesised and reacted with the previously synthesised …
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Synthesis of new chiral pyrylium salts, the corresponding phosphinine and pyridine derivatives and the kinetic studies of the epimerization of pyrylium salts.
… pyridinium salts were also prepared with the thiosemicarbazone moiety. The cytotoxicity and inhibition of cruzain were evaluated and found to be non-actives. Our interest in chiral pyrylium salts led us to investigate the configurational stability of chiral centers alpha to the pyrylium ring. …
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