Global ETD Search
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Showing 1 to 2 of 2 for “"Thiopurines"”.
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Glioma: A Tale of Corticosteroids, Thiopurines and Proposed Novel AntiGlioma Small Molecules
… disorders, and transplantation. However, thiopurines and their metabolites can be inactivated by the thiopurine methyltransferase (TPMT) enzyme. We found that a low TPMT phenotype predicted significantly higher sensitivity to the cytotoxic action of thiopurines than did a high TPMT …
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Homology-Directed Repair of Dna Lesions Generated by the Mismatch Repair Dependent Processing of Cytotoxic Guanine Adducts
… of the damage caused by methylating drugs and thiopurines. Unsuccessful attempts of MMR to remove the mismatch create gaps in the daughter strand generating substrates for HR. In HR-deficient cells, lethal double-stranded breaks accumulate as a result of the inability to process the damage. …