Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Thiol-ene"”.
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Development of orthogonally crosslinked thiol-ene hydrogels for encapsulation of pancreatic beta-cells
… using a visible light-mediated interfacial thiol-ene photopolymerization. Unlike conventional chain-growth visible light polymerizations, no additional cytotoxic co-initiator or co-monomer was required in thiol-ene gelation scheme for rapid gelation. More importantly, islets coated with …
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Step-growth thiol-ene photopolymerization to form degradable, cytocompatible and multi-structural hydrogels
… fate processes. In recent years, step-growth thiol-ene photochemistry has been utilized to form cytocompatible hydrogels for tissue engineering applications. This radical-mediated gelation scheme utilizes norbornene functionalized multi-arm poly(ethylene glycol) (PEGNB) as the macromer and …
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Synthesis and characterisation of small molecule and macromolecular photoredox catalysts for radical thiol-ene reactions
… as photoredox catalysts in the radical hydrothiolation reaction of olefins (thiol-ene reactions) to produce thioethers, which are valuable starting materials in the pharmaceutical industry, material and polymer science, and in the synthesis of various drug molecules. The isolated yields, from …
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Thiol-Ene Click Chemistry for Solid State Triplet-Triplet Annihilation Upconversion and Parts-Per-Billion Pyrophosphate Sensing in Artificial Seawater
<p>Thiol-ene click chemistry is a robust approach to molecularly engineering polymers for many applications. Within this work, thiol-ene click chemistry is used to fabricate thiol-ene networks for TTA-UC and to synthesize a conjugated polyelectrolyte (CPE) used as a pyrophosphate (PPi) sensor in …
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Design, Synthesis, and Characterization of Glycodendrons Through Small Molecule and Linear Polymer Models
… and characterization of glycopolymer-dendron thiol-ene coupling reactions with the long-term goal of increasing biocompatibility of near infrared (NIR) fluorophores for bioimaging applications. A design of experiments was used with small molecule model compounds to determine the parameters for …
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Investigations of Thioether Generation for S-D-Ribosyl-L-homocysteine Synthesis
… This work examines four methods of thioether generation following two mechanisms, bimolecular nucleophilic substitution (S<sub>N</sub>2) and radical-initiated thiol-ene coupling, in an attempt to generate SRH in a more efficient and reproducible manner. Both mechanisms address key objectives …
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Novel Poly(N-substituted glycine)s : synthesis, post-modification, and physical properties
… post-modification of poly(N-allyl glycine) via thiol-ene photo-addition was observed to be quantitative, with the utilization of photo-initiators, and facilitated in the first glyco-peptoid prepared under environmentally benign conditions. Furthermore, poly(N-allyl glycine) demonstrated …
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Versatile multi-component (bio)ink platform for advanced biofabrication
… capabilities, and (2) using norbornene functionalization to enable thiol-ene click chemistry, allowing precise control over the hydrogel's mechanical and biological properties. The results demonstrated that the multicrosslinking approach could be adapted across different bioprinting …
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Synthesis and transformations of 2-thiocarbohydrates
… 2-thiocyanates were reduced to the corresponding thiols using appropriate reagents and reaction conditions. The screening of substrates, stereochemical outcome and the reaction mechanism are discussed briefly (Scheme I). Scheme I. Synthesis of the 2-thiocyanates II and reductions to 2-thiols III & …
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Mikrofluidický enzymatický reaktor pro testování léčiv
… čipů z materiálu OSTE (off-stoichiometry Thiol Ene) metodou "soft" litografie. Následně byla otestována funkčnost vyrobených čipů. Na základě výsledků obou částí experimentální práce bylo provedeno vyhodnocení s posouzením vhodnosti jejich propojení pro budoucí výzkum – testování …
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Immobilized Bis-Indenyl Ligands for Stable and Cost-Effective Metallocene Catalysts of Hydrogenation and Polymerization Reactions
… chemicals, pharmaceuticals, and plastics. Homogeneous catalysts for the processes that have low stability and their separation is difficult. Therefore, the development of new highly active and stable catalysts for hydrogenations and polymerizations is a necessity. The objective of this research …
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Synthetic polypeptide-based hydrogel systems for biomaterials
Hydrogels formed from synthetic polypeptides generated by ring opening polymerization (ROP) of a-amino acid N-carboxyanhydrides (NCAs) present a robust material for modeling the interaction between extracellular matrix (ECM) properties and cellular phenomena. The unique properties of the …
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Nanoparticle transport via holographic photopolymerization
… nanoparticles in holographic syrups containing thiol-ene monomers. Because thiol-ene polymers have significant advantages over acrylates for these systems due to the step-growth polymerization mechanism, this system was chosen for further development as a method to create defined nanoparticle …
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Antibiotic-free antibacterial hydrogels for wound healing applications
… i.e. acrylation by Schotten-Baumann reaction and thiol-ene Michael type addition. Once again, the material was chemically and mechanically characterised, and biological studies were carried out: >99% reduction in the bacterial cell count was observed for both S. aureus and E. coli, with high …
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MECHANICALLY ROBUST BIOCOMPATIBLE POLYMERIC NETWORKS FOR REPETITIVE LOADING
… double-network (DN) hydrogels and (2) thiol-ene-click-based dental resins.In the first system, collagen cryogels were formed through glutaraldehyde (GA) crosslinking, producing hyperelastic and macroporous scaffolds with shape-memory behavior. These cryogels served as the first network …
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Synthesis and Characterization of Polymeric Materials as Sequestrants for Biological Applications
… weights of mannose-functionalized polynorbornenes and modified the polymer backbone with thiolated-mannose and thiolated-amine moieties. Our objective was to increase the antibacterial properties observed with unmodified glycopolymers by increasing glycan density to inhibit bacterial growth …
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Synthesis and investigation of UV-cured, complex amphiphilic polymer films for use in anti-biofouling applications
… surface topography and compositional heterogeneity and a fundamental investigation of their properties. These films were cultivated as non-fluorinated or non-fluorinated/non-PEGylated analogs to the hyperbranched fluoropolymer-poly(ethylene glycol): HBFP-PEG) film system. The coating …
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Herstellung und Untersuchungen von polymerbasierten Wirkstofftransportsystemen
… der Blockcopolymere mittels zwei verschiedener Methoden verknüpft. Eine Methode war die etablierte Kupfer-(I)-katalysierte 1,3-dipolare Cycloaddition von alkinfunktionalisierten Po-lymeren mit den Azid-Derivaten der jeweiligen Kohlenhydrate. Die zweite Methode beruhte auf der Anbindung der …
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Novel Photopolymers for Additive Manufacturing
… has environmental, economic, and production benefits. The high resolution achieved using vat photopolymerisation, together with the new properties, have resulted in new implementations such as biomedical devices or electrically conductive devices. However, harmful printing conditions such as …
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Peptide/Protein Stapling and Unstapling: Introduction and Photorelease of Isobutylene Graft
… most flexible approaches, as a wide range of bis-thiol-reactive linkers are commercially available. More importantly, this efficient and mild modification can be applied on large biomolecules by re-bridging their disulfides. At the same time, the handle introduced by the method provides further …
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