Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 478 for “"Thiol"”.
-
Study on the roles of O-acetylserine (thiol) lyase and thiol dependent reductase 1 of Leishmania
Thiol dependent reductase 1 (TDR1) of Leishmania has been implicated in both the activation of pentavalent antimonial drugs and in the generation of drug-thiol conjugates facilitating drug-resistance. Reverse genetic studies were carried out on TDR1 to elucidate the role of the enzyme and to assess …
-
Biomedical Applications of Thiol-Acrylate Polymers
… development of biocompatible polymers using thiol-acrylate Michael addition reactions between not only acrylates and thiols but also between amines and acrylates were demonstrated. The synthesis of an in situ tertiary amine catalyst initiates the propagation steps of the polymerization …
-
Thiol-Disulfide Exchange in Human Growth Hormone
… our research is to elucidate the mechanisms of thiol-disulfide exchange and disulfide scrambling in therapeutic proteins. To accomplish this goal, model peptides derived from human growth hormone (hGH) and intact hGH were used to investigate reaction mechanisms and kinetics in solution and …
-
Synthesis and Evaluation of Bound Thiol Antioxidants
The reactions of hindered phenolic antioxidants with NR latex in the presence of a free radical generating system have been studied. 3,5-Di-tert-butyl-4-hydroxybenzyl carboxy methyl (BTGA), and ethyl (BTPA) sulphides and 3,5-di-tert-butyl-4-hydroxybenzyl mercaptoglycollate (BTGE) have been found to …
-
Homoglutathione Synthetase And The Plant Thiol-Redox Proteome
… Homoglutathione Synthetase and the Plant Thiol-Redox Proteome by Ashley Galant Doctor of Philosophy in Biology and Biomedical Science: Plant Biology) Washington University in St. Louis, 2011 Professor Joseph M. Jez, Chairperson In the plant cell, redox regulation and redox responsiveness …
-
Characterizing Factors That Influence Intracellular Thiol-Disulfide Equilibrium
<p>Thiol-disulfide balance is critical for the proper functioning of many proteins. Reduced thiol residues can aid in cofactor binding and catalysis, while disulfide bonds are often required for protein folding and stability. Therefore, oxidation of critical cysteine residues can either activate or …
-
The prior thiol capture method for peptide synthesis
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1984
-
Thiol-Based Misfolding: Linking Redox Balance to Cytosolic Proteostasis
… proteins are especially at risk as the thiol side chain is subject to oxidation, adduction and chelation by thiol-reactive compounds. All of these thiol-modifiers have been demonstrated to induce the heat shock response and recruit protein chaperones to sites of presumed protein …
-
Design of Functional Benzoxazine Materials Via Thiol-Mediated Reactions
… the effect of introducing benzoxazines into thiol-alkyne or thiol-alkene networks on the thermal and mechanical properties of the networks. The thiol-alkyne polymer networks were modified by utilizing the ability of the benzoxazine to undergo heat-induced ring-opening polymerization, …
-
Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
… through the manipulation of mitochondrial thiol status. Hearts from exercised rats were better protected from ischemic insults, and this coincided with preserved thiol redox homeostasis and greater stability in mitochondrial bioenergetics. The maintenance of mitochondria thiol was …
-
The Chemical and Mechanical Properties of Thiol Modified ABS
… in tan δ at -80°C. Stabilisers containing the thiol group, notably 3,5-di-tert-butyl-4-hydroxybenzyl mercaptan (BHBM), an antioxidant, and 4-benzoyl-3-hydroxyphenyl-1-O-ethyl thioglycollate (EBHPT), a UV stabiliser, have been bound to ABS in latex and during processing in a high temperature …
-
Investigating Subcellular Thiol Redox Chemistry With Gfp-Based Redox Sensors
… cysteine-containing proteins, thus maintaining thiol-disulfide balance in this organelle is critical for cellular function. Thiol-disulfide equilibrium is primarily controlled by the reduced and oxidized forms of the abundant tripeptide glutathione (GSH and GSSG), which serve as an intracellular …
-
Mechanochromism and Strain-Induced Crystallization in Thiol-yne-derived Stereoelastomers
… of mechanophore activation. Here we report thiol-yne-derived stereoelastomers, doped covalently with a dipropiolate-derivatized spiropyran (SP) mechanophore. Material properties of SP-containing films are consistent with undoped controls, indicating that the SP behaves as a reporter of the …
-
Studies of Reaction Mechanisms Requiring Low Molecular Weight Thiol Cofactors
… bond rather than the nucleophilic attack by thiolate anion which has been pro
-
The maculoprotective effect of a thiol antioxidant in retinal degeneration models
… that N-acetylcysteine amide (NACA), a thiol antioxidant, would protect retinal pigment epithelium and impede the progression of retinal degeneration. The goal of this work was to evaluate the efficacy of NACA in preventing retinal pigment epithelial cell and photoreceptor death in AMD …
-
Thiol-Norbornene Hydrogels With Tunable Mechanical Properties for Engineered Extracellular Matrices
… horseradish peroxidase (HRP) to crosslink thiol-norbornene hydrogel and use mushroom tyrosinase (MT) to create secondary DOPA-dimer crosslinks that stiffened the hydrogel. The cytocompatibility of HRP-mediated thiol-norbornene gelation and the effect of stiffening on cell fate was …
-
Visible Light Cured Thiol-vinyl Hydrogels with Tunable Gelation and Degradation
… hydrogel without using TEA. Specifically, thiol-containing molecules (e.g. dithiothreitol or cysteine-containing peptides) were used to replace TEA as both co-initiator and crosslinker. Co-monomer 1-vinyl-2-pyrrolidinone (NVP) was used to accelerate gelation kinetics. The gelation rate …
-
Spontaneous Unfolding and Refolding of FNIII Domains Assayed by Thiol Exchange
… labels FNIII domains in cell culture. We used thiol reactive DTNB to measure the kinetics of labeling of buried Cys in eleven FN III domains over a wide range of urea concentrations (0-‐‑9M). The kinetics data were globally fit using Mathematica. The results are equivalent to those of H-‐‑D …
-
REDOX PROTEOMICS, THIOL HOMEOSTASIS AND NEUROPHYSIOLOGICAL CORRELATIONS IN AGING AND NEURODEGENERATION
The terms "aging" and "neurodegeneration" are often used in a broad and generalized manner. Actually, they are particularly complex and multifaceted processes, involving different biochemical systems. Increasing evidence supports the notion that reduction of cellular expression and activity of …
Page 1 of 24