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Showing 1 to 5 of 5 for “"Thioglycoside"”.
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Rationalising the inhibition of M. tuberculosis MshB by a series of inhibitors constructed from plumbagin conjugated via a viariable alkyl linker to a phenyl thioglycoside
Infection by M. tuberculosis results in an estimated 1.7 million TB related deaths worldwide. Mycothiol is produced in M. tuberculosis as the dominant low molecular weight thiol and is thought to protect the bacteria against oxidative stress. Since mycothiol is unique to Actinomycetes and is also …
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Synthetic studies of heparan derivatives: Glycosyl couplings and post-glycosylative modifications
… and also by stereoselective coupling of 4-DP thioglycoside donors with various acceptors. The 4’-enol ether can be modified by stereoselective epoxidation and ring opening by a dithiocarbamate auxiliary, which can be activated by copper(I) salts for carbon nucleophile addition with terminal …
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Biological Evaluation Of The Vaccine Candidate Tf-Ps A1 And A One-Pot Multicomponent Coupling/cyclization For Natural Product Herbicide (±)-Thaxtomin A
… employing a suitably protected D-GalN3-thioglycoside donor with N-hydroxysuccinimide. With access to -TF-ONH2, the preparation of the TF-PS A1 vaccine candidate ensued smoothly through oxime bond formation. This construct was then administered to C57/BL6 mice in the presence of titer …
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Entwicklung und Optimierung einer allgemeinen Strategie zur Synthese von multiantennären N-Glycanen des „bisecting“-Typs
… Reaktionsbedingungen geprüft. Ferner wurden Thioglycoside und Trichloracetimidate als Glycosyldonoren in diesen Systemen getestet. Für biantennäre Systeme lieferte die späte Einführung des bisecting-Restes Verbindungen, deren Aufreinigung in ausreichenden Ausbeuten möglich war. Für …
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Synthese und Glycosidasehemmung von Thio-analogen Kohlenhydraten
… Die geschützten 4-O-Tf-galactopyranosylthioglycoside wurden aus den korrespondierenden p-Methoxyphenylglycosiden von GlcNAc nach einer neuen Methode in einer Stufe hergestellt. Die Reaktion der galacto-Triflate mit 2-Acetamido-3,4,6-tri-O-acetyl-2-desoxy-1-thio-ß-D-glucopyranose in …