Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Thioethers"”.
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The reaction of bis(thioether) complexes of (octaethylporphyrinato)ruthenium(II) with dioxygen, and the catalyzed O₂-oxidation of thioethers
This thesis describes a detailed study of the reactivity of Ru(OEP)(RR'S)₂ complexes (where OEP ≋ the dianion of 2,3,7,8,12,13,17,18-octaethylporphyrin, R ≋ methyl, ethyl or decyl, and R' ≋ methyl or ethyl) with 0₂, in various solvents. Exposure to O₂ (or air) of a benzene, toluene or methylene …
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Lewis base catalyzed enantioselective oxysulfenylation of alkenes
… thiiranium ions furnish vicinally functionalized thioethers. The nucleophile scope of the reaction encompasses alcohols, carboxylic acids and phenols. Both inter- and intramolecular sulfenylation reactions were realized. The reaction is highly robust and individual substrates usually did not …
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A general catalytic β-C–H carbonylation of aliphatic amines to β-lactams
… activation reactions such as heteroaromatics and thioethers. The second part of this thesis investigates the mechanism of this C–H carbonylation reaction. Interestingly, the reaction was found not to proceed via a traditional C–H carbonylation mechanism comprising of C–H activation, 1,1-migratory …
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Thioetherification and Etherification Utilizing Trichloroacetimidates Under Thermal Conditions & Progress Towards an Efficient Synthesis of AQX-1125
<p>The synthesis of ethers and thioethers is necessary as the motifs are ubiquitous in natural products, pharmaceuticals, and are quite useful in numerous synthetic applications. While common methodologies prepare simple ether and thioether substrates, the harsh conditions of these techniques make …
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Pd-Catalyzed Cross-Coupling, High Throughput Experimentation, and Machine Learning
… is a reliable method for the synthesis of aryl thioethers, which are important compounds for pharmaceutical and agricultural applications. Since thiols and thiolates strongly bind late transition metals, previous research has focused on catalysts supported by chelating, bisphosphine ligands, …
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Spectroscopic Characterization of H93G Myoglobin Cavity Mutant As A Versatile Protein Scaffold For Modeling Native Heme Iron Coordination Structures and Investigation of the Structure and Mechanism of the Dual-Function Enzyme, Amphitrite Ornata Dehaloperoxidase
… Lys (amines), seleno-Cys (selenols) and Met (thioethers). Particularly, a variety of accurate ambient-temperature mixed-ligand model complexes, hard to achieve with synthetic models in organic solvents, have been successfully prepared by utilizing H93G Mb. All of the newly prepared H93G Mb …
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Harnessing inorganic coordination chemistry for novel sensing applications
… to give chemiresistive detectors for vapors of thioethers. We also show that incorporating permanaganate into the polymer leads to a chemiresistive detector for VOCs susceptible to oxidation. In Chapter 6, we employ 2-D metal-organic frameworks as chemiresistors for the detection of volatile …
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Synthesis and characterisation of small molecule and macromolecular photoredox catalysts for radical thiol-ene reactions
… of olefins (thiol-ene reactions) to produce thioethers, which are valuable starting materials in the pharmaceutical industry, material and polymer science, and in the synthesis of various drug molecules. The isolated yields, from the reaction between thiophenol and styrene, were higher for …
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Synthesis, Characterization, and Mixed-Valence Studies of Conformationally Constrained Bisferrocenyl Complexes for the Study of Through-Space S***π; Interactions
… constrained 2,6-bisferrocenylphenyl thioethers were synthesized via Suzuki-Miyaura cross coupling reactions. Structural information was obtained using X-ray crystallography and dynamic ¹H NMR spectroscopic studies, showing highly constrained m-terphenyl systems. Interaction of the …
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The reaction of ethylene oxide with some proteins, amino acids and vitamins
… secondary amine nitrogen and also the sulfur of thioethers. Imidazole and histidine yield the 1,3-bis-(2-hydroxyethyl)imidazolium derivatives; nicotinamide, nicotinic acid, and pyridine yield the corresponding N-(2-hydroxyethyl)pyridinium compounds; and N-acetylmethionine is converted to …
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Expression, inhibition and in silico modelling of human neuronal nitric oxide synthase
… compounds and iii) modified arginines and thioethers. The high throughput expression/assay system for human nNOS worked well, and although no novel inhibitory compounds were identified, it allowed for the testing of 72 in silico derived compounds. The assay system also allowed for …
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Expanding the chemistry of a cupredoxin by designing nonnative active sites and using abiological metals
… and organic substrate, such as the dyes and thioethers, results in oxidation of the substrate. Short chains of polyaniline were produced when aniline was used as substrate. Another mutant that mimics the site in LPMO with two histidines (HB2Az) was found to not react with peroxidase-like …
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Investigating and engineering the post-translational modifications in RiPP natural product biosynthesis (I) Thiopeptides (II) Sactipeptides
… which also features radically-installed thioethers, but rather than S–Cα linkages, contains six S–Cβ crosslinks to Asp residues. Lastly, we demonstrated using stable isotope labeling that the only previouslycharacterized SCIFF in the literature, thermocellin, does not contain a S–Cα …
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Síntesis de compuestos orgánicos de azufre mediante el empleo de catalizadores metálicos, reactivos electrófilos y ácidos de brønsted
Uno de los principales retos de la Química Orgánica es el diseño de nuevos métodos de síntesis para la obtención de moléculas orgánicas habitualmente difíciles de acceder por otras vías. En este sentido, nuestro grupo de investigación se centra en el estudio de nuevos métodos de Síntesis Orgánica, …