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Showing 1 to 3 of 3 for “"Thioesterases"”.

  1. Characterizing and Engineering Thioesterases as Biocatalysts for Macrocyclization

    Natural products (NP) present themselves as complex molecules with useful and potent biological activities. Notably, macrocyclic NP have garnered significant attention for defying the prototypical "rule of 5" yet retaining optimal pharmacological properties, and the ability to bind to targets with …

    ottawa-retro Repository record for Characterizing and Engineering Thioesterases as Biocatalysts for Macrocyclization (opens in a new tab)

  2. Metabolic flux analysis of Escherichia coli MG1655 under octanoic acid (C8) stress

    … be produced by Escherichia coli engineered with thioesterases specific for short chain fatty acids. However, C8 is toxic to E. coli at concentration greater than 10 mM. To design a better host strain for the production of large amount of SCFAs, 13C metabolic flux analysis of E. coli was performed …

    iastate Repository record for Metabolic flux analysis of Escherichia coli MG1655 under octanoic acid (C8) stress (opens in a new tab)