Global ETD Search
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Showing 1 to 6 of 6 for “"Thioctic acid."”.
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Modified oligonucleotides for the functionalisation of nanoscale materials
… enhanced resonance Raman scattering (SERRS). Thioctic acid was considered a suitable linker group with which to tether oligonucleotides to nanoparticle substrates. As such, routes to the modification of oligonucleotides by thioctic acid are reported herein. Although the phosphoramidite method …
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Nanoparticle sensors for the detection of DNA related to disease
… were successfully functionalised with thiol- and thioctic acid-modified oligonucleotides. To investigate their viability as biosensors, the stability of the conjugates and their hybridisation efficacy was investigated. It was discovered that the thioctic acidmodified oligonucleotide-nanoparticle …
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Investigation of potential intervention targets to improve insulin action: a therapeutic approach
… thiazolidinediones, vanadyl sulphate and thioctic acid. Models used for investigation included the L6 skeletal muscle cell line and isolated skeletal muscles. In vivo studies were undertaken to investigate glycaemia, insulinaemia, satiety and body weight in streptozotocin-induced diabetic …
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The effects of R(+)-lipoic acid supplementation on regulation of human skeletal muscle pyruvate dehydrogenase
… 28 d of supplementation with 1000 mg R(+)-lipoic acid in young sedentary males (age, 22.1 ± 0.67 yr, body mass, 78.7 ± 10.3 kg, n=9). In certain individuals, lipoic acid decreased the 180-min area under the glucose concentration and insulin concentration curve during an oral glucose tolerance test …
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Lipoic acid protein ligases in Plasmodium spp.
… parasite-specific inhibition is feasible. Lipoic acid metabolism in Plasmodium differs from that of mammals in some ways and therefore it might be a promising target for the development of new antimalarials. This study investigated the importance of lipoic acid ligation in P. falciparum using …
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Implications of Advanced Glycation Endproducts in Oxidative Stress and Neurodegenerative Disorders
… the estrogen derivative, 17ß-estradiol, R-(+)-thioctic acid, and a nitrone-based free radical trap, N-tert.-butyl-*-phenylnitrone (PBN). Methylglyoxal (MG) and 3-deoxyglucosone (3-DG), common precursors in the Maillard reaction, were also tested for their ability to induce the production of NO …