Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Thiazolidinedione"”.
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Market Response to Food and Drug Administration's Safety Warnings: a Case Study Using an Interrupted Time Series Analysis of the Medicare Database for 2006-2008
… of a safety warning on the utilization rates of thiazolidinedione oral anti-diabetes medication using an interrupted time series analysis. Methods: We extracted data from a five percent national sample of Medicare Part D beneficiaries for the periods between January 2006 and December 2008. …
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Regulation of Phosphorylation of PPARγ by CDK5 in Obesity
PPAR? is the receptor for thiazolidinedione (TZD) anti-diabetes drugs, and a key regulator of adipose differentiation and insulin sensitivity. Increased heart failure associated with specific TZDs has reduced their clinical use. However recent work suggested that phosphorylation of PPAR? at Ser273 …
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A pharmacokinetic and pharmacodynamic study of pioglitazone in a model of induced insulin resistance in normal horses
… of laminitis in horses with EMS. Pioglitazone, a thiazolidinedione class of anti-diabetic drug, has proven efficacy in humans with type 2 diabetes, a syndrome of insulin resistance sharing some similarities with EMS. The ability of pioglitazone to influence insulin sensitivity in an …
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From Flies to Mice: Drosophila as a Model System to Study Fat Biology
… regulator of adipogenesis and the target of the thiazolidinedione class of anti-diabetic drugs. Adipose inhibits PPARgamma function by directly binding Med23, a component of the Mediator Complex, which connects transcription factors with RNA polymerase II. Taken together, I have shown that both …
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Concurrent Adherence To Multiple Chronic Disease Medications: Examining The Behavior And Issues Concerning Its Measurement
… 2002-2003 and filled both sulfonylurea (su) and thiazolidinedione (tzd). Adherence was measured by proportion of days covered (pdc) over each period of 30 or 90 days and cumulatively. Random components from multivariate multilevel models were analyzed to examine multiple medication adherence …
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Pharmacokinetics and effect of pioglitazone in obese, insulin-resistant cats
Pioglitazone is a thiazolidinedione (TZD) insulin sensitizer approved for use in human type 2 diabetes mellitus. In addition to improving glycemic control, lipid profiles, and pancreatic β-cell function in diabetics, pioglitazone decreases hepatic triglyceride content in humans with non-alcoholic …
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N-Glycosylation profiles as a risk stratification biomarker for Type II Diabetes Mellitus and its associated factors
… alone, or in combination with sulfonylurea and thiazolidinedione, did not improve glycaemic status at follow-up. Many participants using angiotensin converting enzyme inhibitors achieved desired targets for blood pressure control while statins were effective for control of plasma lipids (Study …
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Suppression of Carcinogenesis and Tumor Progression by an Energy Restriction-Mimetic Agent in Murine Models of Prostate Cancer
… and include 2-deoxyglucose, resveratrol, and the thiazolidinedione derivatives OSU-CG12 and OSU-CG5. Here, we characterized OSU-CG5’s mechanism of action in vitro and its chemotherapeutic and chemopreventive activities in vivo. Specifically, we evaluated OSU-CG5’s activity in three different human …
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Investigation of the function, pharmacology and oligomerisation of GPR40, GPR41 and GPR43
… This also allowed the potency of a variety of thiazolidinediones and small molecule agonists to be determined. It was found that troglitazone was the most potent thiazolidinedione tested. Rosiglitazone also acted as an agonist of GPR40, albeit with lower potency than troglitazone, whereas …