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Showing 1 to 1 of 1 for “"Thermofluor"”.
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Analysis and Redesign of Protein-Protein Interactions: A Hotspot-Centric View
<p><p>One of the most significant discoveries from mutational analysis of protein interfaces is that often a large percentage of interface residues negligibly perturb the binding energy upon mutation, while residues in a few critical "hotspots" drastically reduce affinity when mutated. The …