Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Thermodynamic activity"”.
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Mechanistic study of nanoemulsion absorption and its application for permeation enhancement
… first objective was to delineate the effect of thermodynamic activities of the drug in nanoemulsion on the permeation through a barrier. The flux from nanoemulsion depended on the thermodynamic activities of both ionized and unionized species in the aqueous phase of nanoemulsion. A simple …
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Mineral equilibria constraints on open-system melting and consequences of melt loss in metabasic rocks
… the continental crust. The recent development of thermodynamic activity-composition (a-x) relations for high T mineral and melt phases allows the processes of melt generation and segregation to be quantified using high-resolution mineral equilibria modelling for the first time. In this work, …
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Thermodynamics of salt-polymer aqueous two-phase systems: Theory and experiment.
… experiment has been developed to measure the thermodynamic activity data required to evaluate the model parameters. Six different aqueous mixtures of polyethylene glycol 1000 and 8000 and MgSO₄, Na₂SO₄, and Na₂CO₃ were studied at 25°C, 1 ATM. Phase diagrams for these six systems were …
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An investigation of in vitro percutaneous penetration enhancement of benzocaine by azone, dimethylsulfoxide, and 2-pyrrolidone
… 2-pyrrolidone (2-P) under conditions of constant thermodynamic activity in the vehicle. The solubilities of benzocaine in Azone and 80/20, 60/40 and 40/60 V/V DMSO/water systems were found to be 254.17, 533.00, 68.60 and 2.51 mg/ml respectively. All three adjuvants demonstrated a significant but …
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Transdermal Iontophoretic Delivery Of Lipophilic Drugs
… such as transport of intact complex, enhanced thermodynamic activity of drug at the interface and prolonged recovery of barrier disrupted due to iontophoresis.
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The rational design of dermatological formulations
… the various contributing factors, these include thermodynamic activity effects, changes in the ionisation state of the permeant and alteration of the membrane properties. Three model permeants, ibuprofen, salicylic acid and acetaminophen were selected to represent a range of physicochemical …
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Characterization of different hydrophilic polymers and their applicability in hot melt extrusion technology
… increased rate of dissolution due to high thermodynamic activity, they have a potential to revert to the more stable crystalline form. Thorough understanding of the physicochemical properties of amorphous solid dispersions and their corresponding in vivo behavior is required for the …
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Solubility enhancement, mechanical properties and taste masking of poorly water soluble compounds by optimizing hot melt extrusion processing
… of increased dissolution rate because of higher thermodynamic activity, but the compounds still have the tendency to return to their crystalline forms. In order to realize the full potential of HME processes in improving drug delivery, it is necessary to have a comprehensive understanding of the …
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Cytochrome P450 whole cell biohydroxylation of alkanes
… on n-octane and CYP153A13 has shown promising activity on n-octane and n-decane. In the present study, whole cell biocatalysts were prepared by expressing CYPs in E. coli BL21(DE3) and suspended in aqueous media required to maintain whole cell health. Alkanes applied were immiscible with the …