Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Thermal ablation"”.
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Validation Platform for Ultrasound-Based Monitoring of Thermal Ablation
PURPOSE: Thermal ablation therapy is an emerging local cancer treatment to destroy cancer tissue using heat. However variations in blood flow and energy absorption rates make it extremely challenging to monitor thermal changes. Insufficient ablation may lead to recurrence of the cancer while …
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Highly Efficient Thermal Ablation of Silicon and Ablation in Other Materials
… micrometres. Inherent stochastic variations from thermal ablation along with detrimental heat effects, however, limit the feasibility of achieving high precision. The high number of control parameters that make laser micromachining versatile also hinders optimization due to high exploration time. …
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Thermal Ablation Alters The Tumor Microenvironment Activating A Robust Immune Response.
<p>THERMAL ABLATION ALTERS THE TUMOR MICROENVIRONMENT ACTIVATING A ROBUST IMMUNE RESPONSE.</p> <p>Matthew T Campbell, M.D.</p> <p>Advisor Professor: Padmanee Sharma, M.D Ph.D</p> <p>Ablation techniques including radiofrequency ablation (RFA) and cryoablation have been shown to influence the immune …
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Biomechanical Assessment and Monitoring of Thermal Ablation Using Harmonic Motion Imaging for Focused Ultrasound (HMIFU)
… procedure with imaging-guidance, such as cryoablation, laser ablation, radio‐frequency (RF) ablation, and High Intensity F-ocused Ultrasound (HIFU). HIFU is a non-invasive procedure aims to coagulate tissue thermally at a localized focal zone created with noninvasively emitting a set of …
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High-Frequency Irreversible Electroporation (H-FIRE) optimization for the treatment of highly invasive cells beyond the tumor margin
Irreversible electroporation (IRE) is a non-thermal ablation technique that allows for eradication of unresectable tumors in a minimally invasive procedure. While IRE will preferentially kill larger cells over smaller ones, it does not discriminate between cells with larger and small nuclei. Given …
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Drive train improvements and performance evaluation of a robotically steered needle
… drive mechanism intended to robotically steer a thermal ablation electrode. The device is intended to enable more efficient kidney tumor ablation therapy guided by CT scanning. The steering mechanism is based on the concept of substantially straightening a pre-curved Nitinol stylet by retracting …
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Studies on the Application of Multiwalled Carbon Nanotubes for the Thermal Treatment of Cancer
… contrast agents and mediators of tumor-specific thermal ablation when stimulated with near-infrared or radiofrequency energy. Several factors will influence their utility as nanomedicines, chiefly: their compatibility with normal tissues and their efficacy as therapeutic agents. In this thesis we …
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Engineering the Plasmon Resonance of Gold Nanoshells for Biological Applications
… are formed. With a focus on nanoshells for the thermal ablation of cancer cells, 104.5 nm core shell particles having a peak resonance at 940 nm were formed. The study also presents two new methods by which ‘textured’ nanoshells may be formed for use in applications such as substrates for …
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Optimized pulsing of high-intensity focused ultrasound for enhanced therapeutic window
… modality to perform non-invasive surgeries. The thermal ablation technique relies on focusing the non-ionizing acoustic wave within soft tissues to produce a small lesion. HIFU operations are typically attempted by continuous-wave (CW) applications of the beam intervened by wait periods to allow …
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THE USE OF THE CONE-BEAM COMPUTED TOMOGRAPHY FUSION IMAGING AND OF DEDICATED SOFTWARE FOR ABLATION VOLUME PREDICTION IN PERCUTANEOUS MICROWAVE ABLATION OF LIVER PRIMARY TUMORS
… of a protocol for image-guided percutaneous thermal ablation of primary liver tumors that involves the use of cone-beam computed tomography (CBCT), fusion imaging and of a software for ablation volume prediction. Materials and Methods This study included 80 consecutive patients with 101 …
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Strategies for Overcoming Shortcomings of Thermal Ablations: A Comprehensive Study of Nanoparticle Transport During Photothermal Chemotherapy Treatments, and High Frequency Irreversible Electroporation
… research advances into novel treatments. Thermal ablation of tumors is a relatively established method for the destruction of many tumor types, despite inherent shortcomings including incomplete tumor treatment and non-specific treatment. Novel therapies are currently studied including …
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Modeling and Simulation of Radiation from Electronic Transitions in Hypersonic Atmospheric Reentry Flow
… for hypersonic re-entry flows, via inclusion of thermal radiation, is sought. With temperatures reaching tens of thousands of degrees, radiation is known to be significant to chemical reaction rates and thermal boundary layer development, hence surface heat transfer and thermal ablation both to …
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Cavitation methods in therapeutic ultrasound : techniques, mechanisms, and system design
… is currently being developed as a non-invasive thermal ablation technique for benign and cancerous tumors in several organ systems. Although these therapies are designed to ablate tissue purely by thermal means, cavitation, the formation and collapse of gas bubbles, can occur. These bubbles can …
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High Frequency Irreversible Electroporation (H-FIRE) as a Therapeutic Modality for Liver Cancer Treatment and Its Effect on the systemic Extracellular Vesicle Population
… irreversible electroporation (H-FIRE) is a non-thermal ablation technique that uses intense, short, bipolar electrical pulses to induce cell death in cancerous tissues. It's being studied for treating hepatocellular carcinoma (HCC) in dogs. Previous in vitro research suggests H-FIRE may impact …
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Investigation of Histotripsy Cavitation and Acoustic Droplet Vaporization From Perfluorocarbon Nanoparticles
Histotripsy is a non-invasive and non-thermal focused ultrasound therapy that can be used to ablate tissue within the body while overcoming many of the limitations of thermal ablation. Histotripsy utilizes short-duration, high pressure ultrasound pulses to create a cavitation bubble cloud of …
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The Incorporation of Nanomaterials in Cancer Therapy
… to anti-CD44 to target cancer cells and induce thermal ablation via novel microwave radiation. By coupling the power of microwaves with the ability of the CNTs to efficiently absorb heat, antibody-functionalized CNTs (Ab-CNTs) should be able to localize, amplify, and redistribute that heat to …
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Combinatorial Treatments and Technologies for Safe and Effective Targeting of Malignant Gliomas Using High-Frequency Irreversible Electroporation
… cells, disrupt the BBB, and induce non thermal ablation of soft tissues. However, IRE is oftentimes accompanied by undesirable secondary effects such as muscle contractions, complex anesthetic protocols, and susceptibility to electrical heterogeneities, which have impeded its clinical …
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Computer Simulations for Applications of Magnetic Resonance Guided Focused Ultrasound Surgery (MRgFUS) of Uterine Fibroids
… modality utilizing ultrasound energy to perform thermal ablation, has been used clinically as an alternative to hysterectomy to treat UFs since receiving clinical approval in North America and Europe nearly two decades ago. Despite the advantages of MRgFUS being uterine sparing and having a …
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Targeting Breast Cancer With Bacteriophage Associated Silicon Particles
… infrared (NIR) absorbance that could be used for thermal ablation of the tumor as well as for <em>in vivo</em> monitoring using NIR surface enhanced Raman spectroscopy (NIR-SERS). <em>In vitro</em> targeting studies under static and shear flow conditions, as experienced in healthy microvasculature …
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