Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Therapy-induced senescence"”.
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Impact of endosomal recycling inhibitors on drug resistant and immune tolerant breast cancers
… periods of chemotherapeutics and targeted therapy have resulted in the development of acquired resistance through a number of different adaptations. This project focuses on resistance developed by various sub-types of breast cancer cells through drug-therapy-induced senescence. Previous …
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MMP-7 nanosensors for urine-based detection of chemotherapy-induced senescence and pulmonary fibrosis
… causing nearly 1.7 million deaths annually. Senescence is a cellular response to irreparable damage consisting of the implementation of a stable cell cycle arrest and pro-inflammatory activity via the secretion of senescence-associated secretory phenotype (SASP). Senescence is considered a …
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Investigating senescence and senescence-escape in cancer cells
Despite the general concept that therapy-induced senescence (TIS) has a tumour-suppressive role, the presence of senescent tumour cells and the ability of cancer cells to escape from senescence could potentially lead to therapy resistance and tumour recurrence. While a wide range of …
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LINEAGE TRACING REVEALS PAEP AS A CHEMOTHERAPY-INDUCED METASTATIC DRIVER AND EXPOSES METABOLIC VULNERABILITIES OF CIRCULATING TUMOR CELLS IN BREAST CANCER
… anthracycline–cyclophosphamide (AC) chemotherapy. While chemoresistance and metastasis are classically studied in isolation, mounting evidence suggests they are mechanistically intertwined. This thesis interrogates how AC shapes clonal evolution from primary tumors (PT) to metastatic …
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GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE: A NEW MOLECULAR TARGET IN CHEMOTHERAPY
Cancer therapy traditionally seeks to achieve complete tumor eradication via induction of cancer cell death by chemotherapeutic agents or radiation. An alternative strategy is to induce cytostasis, i.e. to arrest proliferation of cancer cells, perhaps in parallel with conventional chemotherapy. …
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Regulation of p21 Function by a Sense Long Non-Coding RNA Generated by Alternative Polyadenylation
… cell-cycle to allow DNA repair and induce either senescence or apoptosis. One of the p53 target genes is <em>CDKN1A</em> which encodes the cyclin dependent kinase inhibitor p21. p21 halts cell-cycle progression in response to DNA damage and can also induce senescence. However, p21 expression in …