Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"Therapy response"”.
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Impact of metabolic pathways on ER+ metastatic breast cancer therapy response
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Identifying Image Derived Features of Radiation Therapy Response: Tumor and Normal Tissue
… these tumors with surgical resection, radiation therapy and chemotherapy presents significant challenges, with cure rates lagging compared to other pediatric cancers. While the introduction of radiation therapy (RT) has significantly improved patient outcome, survivors are never the less prone to …
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Multimodal Machine Learning for mCRC: Designing a Radiopathomics Pipeline for Therapy Response Prediction
L'abstract è presente nell'allegato / the abstract is in the attachment
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Multi-modal molecular imaging of radiation therapy response in the tumour vascular microenvironment
Radiation therapy is recognised globally as a mainstay of treatment in most solid tumours and is essential in both curative and palliative settings. The use of ionising radiation is frequently combined with surgery, either preoperatively or postoperatively, as well as with systemic chemotherapy. …
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Label-free optical signatures of extracellular vesicles and their applications in disease diagnosis and therapy response
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Quantitative Non-Contrast Perfusion Measurements Using Arterial Spin Labeled MRI: Evaluation of Therapy Response in Brain Tumors and Technical Advancements in Kidneys
Current radiological criteria, such as the Response Evaluation Criteria in Solid Tumors (RECIST) or the modified Response Assessment in Neuro-Oncology (RANO), primarily focus on measuring tumor size changes for treatment response assessment. However, these conventional techniques may not detect …
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PET in the evaluation of head and neck cancer treatment - management of the neck
… cell carcinoma (HNSCC) is surgery or (chemo)radiotherapy +/- surgery. Side effects related to therapy are long lasting and adversely affects quality of life. The incidence of oropharyngeal cancer is increasing and patients commonly present an advanced tumour stage with neck metastases at the time …
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Investigating the impact of ageing on the tumour microenvironment and its crosstalk with malignant cells in pancreatic cancer
… which contributes to disease progression and therapy response. PDAC primarily affects elderly individuals as patients are typically diagnosed when 70 years old or older. While ageing has been shown to impact the TME and progression of other malignancies, most pre-clinical studies of PDAC use …
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Genexpressionsanalysen zur Charakterisierung primärer Mammatumoren im neoadjuvanten Setting
… for the prognosis of disease outcome and therapy response. In this study primary mamma carcinomas from patients treated with neoadjuvant therapy were analysed. Correlations between gene expression profiles and clinical parameters (tumour- and patient-associated) were detected using a …
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Proteomic analysis of biomarkers associated with immunotherapy in murine tumour models
… variety of diseases as well as the prediction of therapy response. Mass spectrometry has been used widely, for the discovery and quantitation of disease associated biomarkers using a variety of samples such as serum and tissue. In particular, matrix assisted laser desorption/ionisation time of …
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Investigating the role of HOTTIP, HOXA13 and PSIP1 in cancer.
… drive disease development and progression, and therapy resistance. Long non-coding RNAs (lncRNAs) have gained attention in recent years as potential therapeutic targets for cancer. HOTTIP is one such lncRNA that has previously been implicated in CRC and PCa. HOTTIP is located on the 5’ end of …
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Elucidating Targetable Genetic Vulnerabilities in Relapsed/Refractory Diffuse Large B-cell Lymphoma
… and the immune microenvironment’s influence on therapy response. Our f indings revealed significant enrichment of specific genetic clusters, notably clusters 2 and cluster 5, which are associated with an inferior prognosis and high relapse rates following R-CHOP therapy. These clusters were …
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Targeting S1PR3 to mitigate flow-enhanced invasion in the glioblastoma tumor microenvironment
… factors that influence tumor progression and therapy response. Emerging evidence has implicated pathological interstitial fluid flow, created by high intratumoral pressure relative to the healthy parenchyma, in enhancing cancer invasion. Multiple targetable molecular pathways have been …
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Development of in vivo tumour models for non-invasive proof-of-principle investigation of novel therapeutic agents. Engineering and characterisation of bioluminescent cell reporter systems for in vivo analysis of anti-cancer therapy pharmacodynamics.
… advances in cancer treatment, clinical response remains suboptimal and there is a continued requirement for improved chemotherapeutics. The attrition rate for new therapies is high, due principally to lack of in vivo efficacy and poor pharmacodynamics. Consequently better systems are …
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Leveraging Systems Immunology To Understand The Molecular Underpinnings Of Chimeric Antigen Receptor T-Cell Therapy
Chimeric Antigen Receptor (CAR) T-cell therapy is a promising strategy for the treatment of human cancers, and in the last decade has progressed from breakthrough early trials to first in class FDA approvals for B-cell leukemias and lymphomas. Concurrent with the promise and challenges in cancer …
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MRI Radiomics Modeling and Survival Prediction of Pancreatic Ductal Adenocarcinoma Patients
… tool for patient prognosis and to assess therapy response that may lead to treatment re-planning. This thesis will discuss radiomics-based survival modeling of patients with pancreatic cancer with the goal of early identification and supplementary intervention for patients based on this …
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The Immunosuppressive Function of VEGF Signaling in the Tumor Microenvironment
… growth factor-A (VEGF). As a result, anti-VEGF therapy is commonly employed for cancer treatment. However, anti-VEGF therapy generally provides modest efficacy in cancer patients and therapy-induced hypoxia results in a less differentiated mesenchymal-like tumor cell phenotype, which reinforces …
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Identifying Response to Therapy in Longitudinal PET Imaging Studies
18F-FDG PET can predict response using both qualitative and quantitative measures. PET Therapy Response Assessor (PETTRA) software was developed to allow users to view and analyse pre- and post- therapy images and compute quantitative measures for predicting response to therapy. Additionally, …
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Integrative Biomarker Identification and Classification Using High Throughput Assays
… approach to identify biomarkers predictive to therapy response or survival by integrating multiple assays including gene expression, methylation and copy number data through penalized regression. To identify key cancer-specific genes accounting for multiple mechanisms of regulation, we have …
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Mechanisms of microenvironmental paracrine signaling in cancer chemoresistance
… to the effective treatment of cancer. Cancer therapy occurs in the context of a tissue environment, with cancer cells surrounded by many non-malignant cells that contribute to tumor growth and resistance to therapy. Yet much remains unknown about the tumor microenvironment and its impact on …
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