Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Therapy planning"”.
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New Optimization Technique for Radiation Therapy Planning
<p>The main goal of radiation therapy is to deliver a lethal dose of radiation to the targeted tumor while minimizing the radiation dose to the surrounding normal tissues and critical organs. Modern cancer therapy has benefited enormously from computer controlled treatment devices with increased …
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A thermal model for rapid hyperthermia therapy planning and evaluation
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1995.
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Moment Constraints in Radiation Therapy Planning Optimization Incorporating Patient-Specific Anatomical Geometry
Intensity-modulated proton therapy (IMPT) is an advanced cancer treatment technique, aimed at maximizing tumor control while minimizing collateral damage to surrounding healthy structures. In inverse planning, dose-volume histogram (DVH) is a key concept for measuring and restricting collateral …
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Inverse and transient thermal analysis for rapid hyperthermia therapy planning, delivery and evaluation
The efficacy of hyperthermia therapy can be enhanced if a thermal management system is available for therapy planning, delivery and evaluation. The integrated thermal management system is not yet available, though some components of the system have been developed. For example, MIT Hyperthermia …
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Real-time beam visualization and therapy planning for focused ultrasound therapies using a diagnostic imaging array
… caused by an ultrasound wave. Although FUS therapy is effective at treating many different diseases, FUS therapy can be expensive and time-consuming because the treatment must be planned and monitored using guidance technologies such as magnetic resonance imaging (MRI). Pre-therapy planning …
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Development of A Ct Metal Artifact Management Algorithm For Proton Therapy Planning (Ampp) For Head and Neck Cancer Patients
… investigate its improvement in proton treatment planning.</p> <p><strong>Methods:</strong> The in-house CT metal artifact management method for proton planning (AMPP) uses two angled CT scans to generate a single image set with no metal artifacts posterior to the dental metal implants. The …
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Adaptive Intensity Modulated Radiation Therapy Planning Optimization with Changing Tumor Geometry and Biology Enforcing Both Cumulative and Fraction Size Dose Constraints
<p>Intensity Modulated Radiation Therapy (IMRT) is a modern technique of delivering radiation treatments to cancer patients. In IMRT technology, intensities must be chosen for the many small unit grids into which the beams are divided to produce a desired distribution of dose at points throughout …
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Computer Aided Analysis of Late Gadolinium Enhanced Cardiac MRI
… infarction is essential for diagnosis and therapy planning. Among various clinical cardiac scans, late gadolinium enhanced (LGE) cardiac magnetic resonance (CMR) imaging can directly visualize and thus discriminate non-viable myocardium (i.e., infarcts) from normal myocardium via …
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Investigation of Radiation Injury In The Esophagus From Definitive Chemoradiation Therapy Using Novel Imaging Biomarkers
… dose and potentially interrupting radiation therapy. Clinical quantification of this toxicity is typically achieved by utilizing physician grading scales, assigning complication severity on an ordinal scale of symptom presentation and/or physician chosen interventions. These criteria are …
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Design, Synthesis, and Evaluation of Novel Positron Emission Tomography Radiotracers
… regimen that typically includes surgery, chemotherapy, total body irradiation and autologous stem cell transplantation, the 5-year event-free survival is <50% for high risk patients, and there are numerous long-term side effects associated with treatment. This body of work investigated two …
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The registration of multimodality medical scans
… regions of interest, help in radiation therapy planning, and aid in a myriad of other treatment and diagnostic techniques. However, the registration of the scans is very complex, and no panacea exists for adjusting for the numerous variations and distortions that can occur between scans. …
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Proton Computed Tomography: a novel calibration approach for proton treatment planning
Proton therapy is a cutting-edge radiotherapy modality offering superior dose localization and reduced damage to healthy tissues, made possible by the unique physical characteristics of protons. Accurate prediction of proton range during treatment planning is critical to its success. However, …
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Temporally Feathered Radiation Therapy under Uncertainty
This thesis focuses on radiation therapy planning through novel stochastic optimization models that account for biological heterogeneity and uncertainty in organ-at-risk (OAR) responses. Building on the temporally feathered radiation therapy (TFRT) strategy, we develop a personalized, biologically …
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Design and Optimization of Four-Dimensional Cone-Beam Computed to mography In Image-Guided Radiation Therapy
… anatomy poses a challenge to accurate radiation therapy, especially in lung cancer treatment. Modern radiation therapy planning uses models of tumor respiratory motion to account for target motion in targeting. The tumor motion model can be verified on a per-treatment session basis with …
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Risk of Second Malignant Neoplasms Following Proton Arc Therapy and Volumetric Modulated Arc Therapy For Prostate Cancer
… neoplasms (SMNs) following prostate radiotherapy is a concern due to the large population of survivors and decreasing age at diagnosis. It is known that parallel-opposed beam proton therapy carries a lower risk than photon IMRT. However, a comparison of SMN risk following proton and photon …
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Personalized Biomechanical Heart Modeling for Clinical Applications
… effect of the Cardiac Resynchronization Therapy (CRT) by means of an increase of ‘max LV dp/dt’. The model personalization was performed using patients MRI and pressure data in the baseline condition — prior to CRT. Then we fixed the values of all parameters and applied electrical …
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Improving ion beam therapy treatment planning for metal implants by using dual-energy CT scanning
One of the major uncertainties in ion beam therapy planning is the calculation of ion ranges in the patient’s tissue from CT images. The presence of non-tissue-equivalent mate- rials and materials with high photon attenuation like metals may aggravate this problem. Dual Energy Computed Tomography …
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IMAGE-BASED RESPIRATORY MOTION EXTRACTION AND RESPIRATION-CORRELATED CONE BEAM CT (4D-CBCT) RECONSTRUCTION
… helps improve targeting precision in radiation therapy. Respiratory motion can be a major source of error in determining the position of thoracic and upper abdominal tumor targets during radiotherapy. Thus, extracting respiratory motion is a key task in radiation therapy planning. …
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Dynamic Magnetic Resonance Imaging for Tumor Prognosis
… cancers among American women and men. Radiotherapy and chemotherapy in conjunction with surgery are the most common treatment protocols in the clinic. However, a lot of experimental and clinical studies have shown that tumor hypoxia and the microcirculation play a very important role in …
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Improved statistical quantitation of dynamic PET scans
… role in a variety of tasks related to diagnosis, therapy planning, prognosis and treatment monitoring by injecting a radiotracer to characterize the specific biologic process (e.g., tumor metabolism, proliferation or blood flow). The standardized uptake value (SUV) obtained at a single time point …