Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 57 for “"Therapy Resistance"”.
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Mapping the therapy resistance landscapes of acute leukemias using in vivo functional genomics
The recurrence of therapy resistant disease remains an intractable problem in oncology clinical care. To address this issue, investigators have traditionally focused on elucidating cell-intrinsic mechanisms that render tumors refractory to both classical chemotherapeutics and targeted agents. …
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Unveiling Immune Checkpoint Therapy Resistance Mechanisms In The Tumor Microenvironment Using High-Dimensional Analyses
<p>The advent of immune checkpoint therapy (ICT) has transformed cancer treatment, but its effectiveness is limited in certain cancers like pancreatic ductal adenocarcinoma (PDAC), which exhibit resistance to this therapy. To overcome this challenge, it is crucial to understand the underlying …
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Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance
Resistance to cancer therapy is common and understanding mechanisms of resistance is critical to drive development of next generation therapies. We demonstrate that cancer cells co-opt anti-viral signaling to sustain genetic programs that drive resistance to multiple anti-cancer modalities. In the …
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Development of Specific Inhibitors that Prevent hnRNPA1-Mediated Therapy Resistance in Small Cell Lung Cancer.
… This indicates that SCLC cells have a multidrug resistance to therapies subsequently leading to poor prognosis. Fibroblast growth factor 2 (FGF-2) signalling leads to cell death resistance by providing cancerous cells with survival signals that leads to therapy resistance. FGF-2 signalling …
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Exploring vasculogenic mimicry and anti-angiogenic therapy resistance within breast cancer patient-derived tissue xenograft models
… tumour neovascularisation with anti-angiogenic therapy (AAT) holds much promise to halt tumour growth and inhibit metastasis, however AAT trials have not delivered the predicted clinical success in a large amount of the cancer types tested, including breast cancer. It has become increasingly …
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Proteomic Investigation of Endocrine Therapy Resistance in Breast Cancer Investigating the Molecular Mechanisms for SERM Resistant Cell Lines Using SILAC-Based Proteomic Approach
… of cancer mortality in women worldwide. Hormonal therapy is considered one of the most effective therapies and is used against luminal-type malignancies. However, 40-50% of tumour cells can develop resistance, thereby limiting the success in breast cancer treatment. In this study, mechanisms of …
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Antioxidant Programs Are Essential for Enzalutamide-Resistant Prostate Cancer
Therapy resistance to second generation androgen receptor (AR) antagonists, such as enzalutamide, is common in patients with advanced prostate cancer (PCa). In order to identify which patients will develop therapy resistance and the underlying cause, it is critical to characterize detailed …
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The Role of Glucocorticoid Signaling in Prostate Cancer Health Disparities
… genes that promote tumor aggressiveness and therapy-resistance. This is problematic as African-American men have hypersensitive GR signaling and chronically-elevated levels of glucocorticoids linked to cumulative stressful life events. To explore the role of glucocorticoid signaling in PCa …
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Investigating the role of HOTTIP, HOXA13 and PSIP1 in cancer.
… drive disease development and progression, and therapy resistance. Long non-coding RNAs (lncRNAs) have gained attention in recent years as potential therapeutic targets for cancer. HOTTIP is one such lncRNA that has previously been implicated in CRC and PCa. HOTTIP is located on the 5’ end of …
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Prostate Cancer Stem Cells: Drug to lerance, Experimental Reconstitution and Castration Resistance
… progression, recurrence, metastasis and therapy resistance. Like CSC studies in other cancer types, it has been reported that PCa also contains CSCs. However, there remain several unresolved questions that need to be clarified. <em>First</em>, the relationship between prostate CSCs …
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The Role of Androgen Receptor Signalling in Endocrine Resistant Breast Cancer
… which are successful in many patients, but therapy resistance represents a major clinical issue. The Androgen Receptor (AR) is a transcription factor that is more highly expressed than ERα in BCa, and mediates the functions of androgens. In early forms of ERα-positive disease, AR is a …
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Efficacy of novel immunotherapeutic strategies targeting L1CAM in pancreatic cancer
… treatment, early metastasis and profound therapy resistance. A promising target for new therapeutic options is the L1 cell adhesion molecule (L1CAM) which is upregulated in PDAC cells in most PDAC tissues and associated with different hallmarks of cancer contributing to therapy resistance, …
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Uncovering The Zeb1 Interactome to Identify Novel Regulators of Metastatic Non-Small Cell Lung Cancer
… with NSCLC disease progression and to confer therapy resistance in multiple tumor types. Additionally, depletion of ZEB1 has been found to reverse therapy resistance, hence uncovering regulators of ZEB1 provides promise for innovative therapeutic strategies that may improve lung cancer patient …
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The Role of Mir-34A In Inhibition of Prostate Tumor Growth In The Bone and Induction of Autophagy
… survival has only marginally improved due to therapy resistance, which often arises from constitutive activation of compensatory signaling pathways. This dissertation work focused on a mechanistic understanding of how cross talk between tyrosine kinase receptors contributes to therapy …
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Curcumin: A Multi-dimensional Approach to Pancreatic Cancer Targeting Cell Death and Exosomes
… rates are attributable in part to increasing resistance to cancer therapy. Cancer therapy resistance is caused by adaptations that favor survival within cancer cells and their environment, termed the tumor microenvironment. Intracellular adaptations include the overexpression of …
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RNA-Seq Reveals Transcriptomic Program Associated with Stemness in Taxane Resistant Prostate Cancer
… advanced prostate cancer (PCa), and taxane chemotherapy is the only treatment option once other therapies have failed. However, this is problematic since all patients eventually develop chemoresistance. Emerging treatments for advanced PCa have shown promise at the benchside, but clinical trials …
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Investigation of the role of Col4a1 and Itga11 in enzalutamide resistance of prostate cancer cells
… males in the Western World. Androgen Deprivation Therapy (ADT) is initially effective in patients with localized prostate cancer (PCa), but eventually, cancer cells develop resistance to therapy and progress into Castration-Resistant Prostate Cancer (CRPC). CRPC is very likely to metastasise to …
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Integrative Bioinformatics Approaches to Elucidating Prostate Cancer Cell Heterogeneity, Plasticity, and Treatment Response
… heterogeneous tumors containing metastatic and therapy-resistant cancer cells. Cancer stem cells (CSC) are an important contributor to this tumor heterogeneity, which are present in primary tumors and become enriched in castration resistant PCa (CRPC). Our lab has demonstrated that the prostate …
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Concomitant Inhibition of Flt3 and Mcl-1 In Flt3 Mutated Acute Myeloid Leukemia
… of FLT3-mutated AML through the development of therapy resistance. Among mechanisms of resistance to TKI that arise from non-FLT3 dependent pathways, most notable are the resistance mechanisms relating to the cell's systems which govern the apoptotic process. This has led to interest in the …
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SOX2 is Associated with Changes in DNA Damage Repair and Cell Cycle Gene Expression and Regulates E2F1
… progression in prostate cancer patients is therapy resistance. As a result, different treatment schemes and combinations are employed to combat prostate cancer, advancing to more deadly prostate cancer. One mechanism that cancer cells utilize to evade treatment is through alterations in DNA …
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