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Showing 1 to 3 of 3 for “"Therapy Optimization"”.
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Intensity Modulated Proton Therapy Optimization Under Uncertainty: Field Misalignment and Internal Organ Motion
Intensity modulated proton therapy (IMPT) is one of the most advanced forms of radiation therapy, which can deliver a highly conformal dose to the tumor while sparing the dose in healthy tissues. Compared to conventional photon-based radiation therapy, IMPT is more flexible in delivering radiation …
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DUPA α-Amanitin Conjugates for Targeted Prostate Cancer Therapy - Optimization and Evaluation of In Vivo Potency
… limitations in the use of ADCs in solid tumor therapy seems to be restrained tumor penetration due to the high molecular size of this class of therapeutics. In this work a library of small molecule drug conjugates (SMDCs) as an alternative for large molecular ADCs was developed and tested in …
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Mathematical Modeling of Therapies for MCF7 Breast Cancer Cells
… the continuous application of any targeted therapy often results in resistance to the therapy. Our ultimate goal is to use mathematical modelling to optimize alternating therapies that not only decrease proliferation but also stave off resistance. Toward this end, we measured levels of key …