Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Therapeutic target discovery"”.
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OPTIMISATION AND THERAPEUTIC-TARGET-DISCOVERY ORIENTED ANALYSIS OF CRISPR-CAS9 SCREENS
… has revolutionized cancer research by enabling targeted genome modifications in tumour cells, offering insights into cancer biology and potential treatment targets. My PhD research focuses on developing tailored tools and pipelines to enhance the analysis of CRISPR-Cas9 screens for identifying …
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Characterizing Failure Modes in Continuous Flow Microfluidic Pumps
… provide novel platforms for drug testing and therapeutic target discovery, through their three-dimensional morphologies that mimic specific tissues and organs. In concurrence with these systems, microfluidic channels allow for a sufficient supply of nutrients to the cell culture; by creating …
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Integrating Functional Genomics with Systems Biology to Discover Drivers and Therapeutic Targets of Human Malignancies
… for loss-of-function studies that may lead to therapeutic target discovery for human malignancies in the era of personalized medicine. However, due to high false-positive and false-negative rates arising from noise of high-throughput measurements and off-target effects, powerful computational …
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Determining therapeutically actionable genetic interactions in human cancer at scale using multiplexed CRISPR screening
… in precision oncology, enabling the selective targeting of gene loss in cancer. This study employed a high-throughput multiplexed combinatorial CRISPR/Cas9 pooled screening approach to systematically identify SL interactions. A novel tRNA-based dual guide expression system was used to construct …
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Novel Statistical Methods for Mediation Analysis with High-dimensional Omics Mediators
… foundational insights for precision medicine and therapeutic target discovery.</p>