Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 579 for “"Therapeutic target"”.
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Telomerase a prognostic marker an therapeutic target
… cancer cells, is an attractive molecular target in glioma therapeutics. The aim of this thesis was to silence telomerase at the genetic level with a view to highlight the changes caused in the cancer proteome and identify the potential downstream pathways controlled by telomerase in tumour …
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MUTANT P53 AS A THERAPEUTIC TARGET IN CANCER
Identifying therapeutic approaches to target TP53 mutations has the potential to revolutionize cancer treatment. TP53, the gene that encodes the prominent tumor suppressor protein p53, is mutated and inactivated in half of sporadic human tumors. Additionally, individuals who harbor germline TP53 …
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Investigating WDR12 as a Therapeutic Target in Breast Cancer
… in women. Presently, there is a need for novel targets for the development of improved therapeutics. Data mining through genetic screens suggests that the ribosome biogenesis protein WDR12 is essential for breast cancer cell proliferation. In this study, we characterize the effects of WDR12 …
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CD200: A Novel Therapeutic Target for Chronic Lymphocytic Leukemia
… biology, and suggests it may represent a novel therapeutic target for CLL.
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Metabolic Manipulation of Glutathione as an Anticancer Therapeutic Target
… the potential of redox-buffering systems as therapeutic targets for selective antineoplastic growth.
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Investigating HK2 as a potential therapeutic target in glioblastoma
… compelling need for the development of effective therapeutics. An approach is to target abnormal metabolic pathways that are universally dysregulated in glioblastoma. The identification of potential targets and the development of therapeutic agents is crucial for the advancement of treatment. …
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EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
… unclear, and must be elucidated to examine the therapeutic potential of these proteins. This work investigated the role of EPAC1 in promoting invasion and metastasis of pancreatic ductal adenocarcinoma (PDA) and immune regulation, through modulation of the activity of regulatory T-cells (Treg), …
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Androgen Receptor: A Complex Therapeutic Target in Breast Cancer
… (HER2). Breast cancers that express these targets are classified as hormone receptor (HR) positive breast cancer and the tumors that lack the expression of these markers are classified as triple negative breast cancer (TNBC). Though HR-positive breast cancer is treated with hormonal and …
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CD147 AS A POTENTIAL THERAPEUTIC TARGET IN GLIOBLASTOMA TREATMENT
… highlights different pathways to potentially target for therapeutic treatments. The human surface glycoprotein CD147, also known as basigin, is expressed at significantly higher levels in GBMs compared to non-neoplastic brain tissue. Furthermore, levels of CD147 expression correlate with brain …
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Identification of PRMT5 as a therapeutic target in cholangiocarcinoma
… context of precision medicine and molecularly targeted therapies, understanding the genetic and epigenetic mechanisms underlying CCA development and progression is crucial. This study aims to explore the role of Protein Arginine Methyltransferase 5 (PRMT5) in cholangiocarcinoma, focusing on its …
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Validation of AXL as a Therapeutic Target in Pancreatic Cancer
… emphasizing the potential of AXL as a therapeutic target for pancreatic cancer patients. Multiple pharmacological strategies to inhibit AXL have been explored in pre-clinical models of PDA with promising therapeutic efficacy and similar phenotypes as genetically manipulation of AXL. …
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OPTIMISATION AND THERAPEUTIC-TARGET-DISCOVERY ORIENTED ANALYSIS OF CRISPR-CAS9 SCREENS
… has revolutionized cancer research by enabling targeted genome modifications in tumour cells, offering insights into cancer biology and potential treatment targets. My PhD research focuses on developing tailored tools and pipelines to enhance the analysis of CRISPR-Cas9 screens for identifying …
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rRNA transcription as potential therapeutic target in triple negative breast cancers
… the rRNA transcription has emerged as novel target for anti-cancer therapy and number of specific RNAP1 transcription inhibitors are currently undergoing clinical trials as anti-cancer agents and the selective inhibition of RNAP1 transcription is he novel strategy against number of cancers …
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Phosphoglycerate kinase 1 as a therapeutic target in motor neuron disease
… in cells and therefore its suitability as a therapeutic target is not known. Overexpression of PGK1 has been shown to be beneficial in multiple models of MND but the most commonly used PGK1 agonist, terazosin, is non-specific and so there is a need to develop more effective and more specific …
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Connexin43 as a novel therapeutic target in age-related macular degeneration
… modulation of Cx43 channels provides a potential target for the treatment of AMD.
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Investigating procaspase-3 as a potential therapeutic target in canine osteosarcoma
… executioner of apoptosis makes it an ideal drug target for circumventing such upstream disruptions and restoring effective apoptosis in cancer cells. This work investigates the use of PAC-1, a newly developed procaspase-3 activating compound, in the treatment of canine osteosarcoma. Procaspase-3 …
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Hedgehog signaling: a potential therapeutic target for non-small cell lung cancer
… calls for innovative research for finding novel therapeutic targets and agents for better treatment outcome.</p> <p>Emerging evidences have suggested that a phenomenon called Epithelial-to-Mesenchymal Transition (EMT), which shares similar molecular characteristics with cancer stem-like cells, …
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Epigenetic Modification as a Therapeutic Target in BRAFV600E-mutated Metastatic Colorectal Cancer
… including Wnt pathway genes. EZH2 inhibitors targeting H3K27me3 additively sensitized DNMT inhibitors in BRAF<sup>V600E</sup> CRC. Additionally, the combination of bromodomain and extra-terminal protein (BET) inhibition in vivo with standard MAPK-targeted therapies showed deeper inhibition of …
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Myeloma-osteoclast interactions as a therapeutic target for multiple myeloma bone disease
<p>Multiple myeloma (MM) is a cancer of terminally differentiated B lymphocytes, also known as plasma cells, which are cells specialized in generating antibodies. MM is responsible for 35,000 diagnoses and 13,000 deaths in the US annually. While both malignant and non-malignant plasma cells …
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Validation of KLK-6 as a New Therapeutic Target for Parkinsons Disease
Η α-συνουκλεΐνη (α-Syn) αποτελεί μια προσυναπτική νευρωνική πρωτεΐνη που εμπλέκεται γενετικά και βιοχημικά σε μια ομάδα νευροεκφυλιστικών νοσημάτων γνωστών ως συνουκλεϊνοπάθειες. Παθολογικές μορφές της α-Syn έχουν συσχετιστεί με την ανάπτυξη της νόσου Πάρκινσον (PD), ενώ έχει αποδειχθεί ότι …
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