Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 541 for “"Therapeutic strategies"”.
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Optimising therapeutic strategies for chronic rhinosinusitis
… is to evaluate and optimise current pharmacotherapeutic options in rhinosinusitis. There is often a marked variation in treatment response in those afflicted with chronic rhinosinusitis, both within and between patients, attributable in part to different disease phenotypes/endotypes, poor …
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Modeling Therapeutic Strategies for Diabetic Pathologies
<p>No abstract available</p>
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New therapeutic strategies against trypanosomiasis and leishmaniasis
Leishmaniasis and African Trypanosomiasis are diseases caused by the Kinetoplastida parasites of Leishmania sp. and Trypanosoma sp. respectively. Control and management of these diseases, which affect a significant number of people in the tropics and subtropical areas of the world, is beset with …
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New Therapeutic Strategies for Amyotrophic Lateral Sclerosis Treatment
… for ALS and compelling preclinical data, new therapeutic strategies have highlighted this disease as a candidate for stem cell treatment. Here we investigated whether neural induction enhances therapeutic potentials of mesenchymal stem cells (MSCs). We induced neural induction of MSCs by …
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Development of Novel Therapeutic Strategies for Pancreatic Cancer Treatment
… research efforts are underway to discover new therapeutic options to treat PanCa and overcome resistance to available therapies.</p> <p>Mucin, MUC13 is transmembrane glycoprotein, which is aberrantly overexpressed in PanCa and promoting cancer growth. Structural domains of MUC13, lead to …
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Novel anti-endothelial therapeutic strategies in malignant melanoma : the metronomic approach.
Treatment strategies for advanced malignancy remain limited in their success, despite major advances in the understanding of cancer aetiology and molecular biology. The incidence of many cancers, including melanoma, continues to rise, with a huge demand for therapies even if treatment goals are …
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Characterization of Bone Pathology in Sickle Cell Disease and Therapeutic Strategies
<p>Sickle cell disease (SCD) is a genetic hemoglobinopathy that has grown into a global health concern. While the advances in medical treatment and management of SCD during childhood have drastically improved the overall survival of children, the transition from pediatric to adult services is …
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On transient assemblies in amyloid formation: mechanistic insights and therapeutic strategies
… with implications for their stability and therapeutic strategies.
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CROSSTALK BETWEEN GLIOMA CELLS AND TUMOR ASSOCIATED-MACROPHAGES: MECHANISMS AND THERAPEUTIC STRATEGIES
… are associated with IDH-mutations. Despite many therapeutic strategies, GBM recur in almost all patients and prognosis remain poor, the development of new therapeutic strategies is strongly needed. In the last decades, innovative engineered nanovectors bears a promise for GBM treatment: these …
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Therapeutic Strategies to Target LILRB Receptors on Myeloid Cells for Cancer Immunotherapy
The existing T cell-centered immune checkpoint blockade therapies have been successful in treating some but not all patients with cancer. Immunosuppressive myeloid cells which inhibit anti-tumor immunity are recognized as one of the major obstacles in cancer treatment. LILRB3 and LILRB4, immune …
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Preclinical Development of Therapeutic Strategies Against Triple-Negative and Inflammatory Breast Cancer
… prevents the development of effective therapeutic strategies. To identify effective treatments, we explored aberrant apoptosis pathways and cell membrane fluidity as novel therapeutic targets.</p> <p>We first identified an effective therapeutic strategy against TNBC and IBC by …
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Identification of novel biomarkers and therapeutic strategies in triple negative breast cancer
… analysis by identifying novel biomarkers and therapeutic targets that can be exploited to allow a personalised approach to the treatment of TNBC. Firstly, a hypothesis-led approach will characterise the role of NR3C1, which encodes the glucocorticoid receptor (GR) in TNBC as a biomarker and a …
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Therapeutic strategies of Parkinson's disease: Alternative dopamine replacement and potential drug targets
… life. Moreover, the need for identifying a new therapeutic target that can prevent continuous neurodegeneration is highly required. Chapter 2 of this dissertation provides evidence that a novel approach of using systemic delivery of genetically engineered, plasmid-based, and regulatable …
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Investigation of novel therapeutic strategies in B cell and antibody mediated disease
… of IL10. In this thesis I firstly explored the therapeutic potential of belimumab, an anti-BLyS antibody, in an experimental medicine study in kidney transplant recipients. The rationale for this study was based on published studies showing that B cells activate alloreactive T cells and secrete …
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Amyotrophic Lateral Sclerosis: mechanism behind mutant SOD toxicity and improving current therapeutic strategies
… inhibition of nitrated Hsp90 may be a novel therapeutic approach for ALS. An alternative therapeutic strategy is to target the production of survival factors by glial cells. Riluzole is the only FDA approved drug for the treatment of ALS and it shows a small but significant increase in …
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The use of ultrasound to facilitate the delivery of genetic-based therapeutic strategies
(cont.) preliminary experiments will eventually lead to a clinical methodology where ultrasound-enhanced gene therapy transfection would be followed with ultrasound-directed spatial control of gene expression.
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Investigating Therapeutic Strategies to Target Metabolic Vulnerabilities of Nsclc Tumors With Mutant Keap1 Gene
… as an attractive window to develop novel therapeutic strategies. Metabolic flexibility at the cellular level encompasses the efficient rerouting of anabolic and catabolic pathways in response to varying environmental stimuli to maintain cellular homeostasis and sustain proliferation. The …
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