Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 55 for “"Therapeutic implications"”.
-
Tumor Cell Glutathione Metabolism: Therapeutic Implications
<p>In response to oxidative injury murine tumors depend upon the GSH oxidation-reduction cycle. The susceptibility of tumor cells to lysis by a flux of H<sub>2</sub>O<sub>2</sub>, such as generated by granulocytes or activated macrophages, or by the enzyme glucose oxidase, was augmented by …
-
Neuroblastoma: A Theoretical Dose Dependent Study With Therapeutic Implications
… that I believe will elucidate potential therapeutic treatment options. New dosages and combinations of drugs may be the key in preventing the relapse of NB.</p>
-
Military Sexual Trauma in Veterans: Consequences, Treatment, and Therapeutic Implications
… effective for MST-related PTSD, and clinical implications for working with MST survivors. At this time, Cognitive Processing Therapy, Prolonged Exposure, and Eye Movement Desensitization and Reprocessing are considered by Veterans Affairs to be the “gold standard” evidence-based PTSD …
-
Molecular regulation of glioma cell migration: assessment and therapeutic implications
… of glioma cell migration: assessment and therapeutic implications Florian Gessler Glioblastomas are among of the most aggressive human tumour types. Overall survival in patients with this malignancy is no longer than 18 months despite receiving extensive therapy. The development of a …
-
Duchenne muscular dystrophy and extraocular muscle: a potential sparing mechanism with therapeutic implications.
This project investigates the role of extraocular muscle (EOM) progenitor cells in sparing the muscles from pathology associated with Duchenne Muscular Dystrophy (DMD). Mouse models of muscular dystrophy and wild type mice were analyzed by flow cytometry and cell culture for the size, heterogeneity …
-
Molecular And Therapeutic Implications Of Notch1 Signaling In Pediatric T-Cell Acute Lymphoblastic Leukemia
… <p>NOTCH1 is a potentially attractive therapeutic target for T-ALL since constitutively activating effects of mutant NOTCH1 can be abolished with -secretase inhibitors (GSIs). Because of possible effects of GSIs on other cellular targets in addition to NOTCH1, we explored shRNA …
-
Low Reactive Oxygen Species and High Glycolysis In Glioblastoma Stem Cells:Mechanisms and Therapeutic Implications
… of a glycolytic inhibitor 3-BrOP and a chemotherapeutic agent BCNU depleted cellular ATP and inhibited the repair of BCNU-induced DNA damage, achieving strikingly synergistic killing effects in drug resistant GSCs.</p> <p>This study uncovers the metabolic properties of glioblastoma stem cells …
-
Exploring betweenness: an autoethnographic journey into the experience of twinship and its therapeutic implications
… and from harmony to estrangement. Practice-based implications and considerations for clinical work with twins are subsequently proposed, with the psychotherapeutic situation identified as a potentially helpful and healing ‘between world’ for twins. The ways in which twins react differently from …
-
Inhibition of human platelet aggregation by perhexiline maleate : mechanisms and therapeutic implications / Scott Richard Willoughby.
… effect which may contribute to its proven therapeutic efficacy.
-
Wittgenstein and irreducible uncertainty: therapeutic implications for education of a non-local model of mind
This thesis proposes a new model of mind based on the philosophy of Wittgenstein and offers an application of the model to the current educational context. The thesis first analyses the context of the major contending models of mind. Despite widely differing approaches, each model provides a theory …
-
Onset of Insulin Resistance in Hippocampal Synapses After Traumatic Brain Injury: Relevance to Alzheimer’s disease and Therapeutic Implications
… therapy for AD, this gives valuable insight into therapeutic implications of treating AD patients based on a patient’s history of associated risk factors.
-
Where Does it Stem From? - Functional Neuroimaging of Monoaminergic Brainstem Nuclei in Altered States of Consciousness: Translational, Diagnostic and Therapeutic Implications
… functionality that might underpin psychedelic therapeutic effects, e.g. in depression. Chapter V tested said hypothesis of psychedelic-induced sub-/post-acute raphe changes in two depression cohorts who received psilocybin. In data-driven analyses, I found that only post-acute connectivity of …
-
Endovascular treatment of post-traumatic carotid-cavernous fistulae with latex detachable balloons
… based on the pattern of arterial supply and has therapeutic implications.
-
An investigation of the psychological, physiological and endocrinological factors underlying two types of alcoholism
… responses were not significant. The results have therapeutic implications.
-
Families under stress: Using the Double ABCX model to understand attachment relationships in families during military deployment
… the influence of meaning making and adjustment. Therapeutic implications and suggestions for future research are also discussed.
-
Resident and Counselor Relationships in a Court Affiliated Residential Treatment Setting
… to previous research in order to explore the therapeutic relationship in light of attachment. Therapeutic implications and areas of future research are also discussed.
-
Macromolecular Complexes of Cystic Fibrosis Transmembrane Conductance Regulator Alter Fluid Transport in inflammatory Bowel Disorders
… to Nherf2+/+. Our findings have important therapeutic implications in IBD and other forms of gastrointestinal inflammations.</p>
-
Fathers and young-adult children: factors affecting relationship strength
… strength. Explanations for the findings, therapeutic implications, and suggestions for future research were explored.
Page 1 of 3