Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Therapeutic gain"”.
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Optimized pulsing of high-intensity focused ultrasound for enhanced therapeutic window
… (pHIFU) parameters in the enhancement of the therapeutic gain within the HIFU focus. A therapeutic gain is observed when high duty cycle pHIFU is pulsed at the mechanical resonance of the medium. Up to 50% increase in temperature was measured in lab-prepared tissue mimicking phantoms. The …
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All Therapies Are Equal - Unless You’re a Bot: Evaluating the Effectiveness of Four Therapy Schools for AI Chatbot Therapists
… Language Model (LLM) Chatbot Therapists: Which therapeutic school suits an LLM best, and does an explicit Theory-of-Mind (ToM) reflection improve outcomes? We prompted GPT-4.1-mini to act as eight therapists — CBT, Narrative, Psychodynamic, and SFBT, each with and without a ToM step — and held …
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Enhancing the radio sensitivity of prostate cancer using RALA Gold nano-complexes
… clinical potential. In PCa there is a distinct therapeutic window between normal and malignant tissue, providing an opportunity to exploit for therapeutic gain. This thesis explored ways to improve the use of RT through the application of radiosensitisers, with particular focus on the use of …
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pH-sensitive core-shell nanoparticles for intracellular drug delivery
Therapeutics such as proteins, DNA, or siRNA, can only exert their function in the cell cytosol or nucleus. However, most of them are cell membrane impermeable molecules that can only be taken up by cells via endocytosis or phagocytosis. Such drug molecules are thus confined in endolysosomes, where …
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The intersection of metabolism and oxygen in T cell function and anti-tumour immunity
… manipulation of oxygen sensing pathways for therapeutic gain in the context of cancer. The data presented here describe glutarate as an important metabolite with significant T cell modulatory capacity whilst also highlighting the important role of molecular oxygen in T cell activation and …
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Causes and Consequences of Genomic Instability in Prostatic Carcinogenesis
… senescence that may be exploited for therapeutic gain. These understandings may also help tailor management for prostate cancer such as risk stratification for men with HPIN and the use of targeted agents such as AKT inhibitors and telomerase inhibitors. In more advanced disease, …
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Role of mural Cx43 in vascular interactions and its regulation by breast tumor cells
… S368 phosphorylation but does not protect against Cx43 loss following long-term tumor CM treatment. Similarly, tumor mural CM activates mural cell MAPKs to induce phosphorylation at Cx43 S255 and S279/282 while MAPK inhibitor UO126 prevents target site phosphorylation, it does not prevent …
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Proteomic identification of putative biomarkers of radiotherapy resistance
… with ionising radiation in the absence of therapeutic gain. The aim of this project was to identify protein biomarkers predictive of radiotherapy response using comparative proteomic platforms to study radioresistant cell line models. The identification of such biomarkers will enable …
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Effects of Concurrent Radiosensitization and Chemoradiotherapy for Brain Tumors
… treated with QDs, CQDs, and GQDs as well as chemotherapeutic drugs such as Temozolomide (TMZ). Results and Conclusions: Cell survival curves from clonogenic assays show an increase (p < 0.0001) in cell death with an increase in radiation, but no statistically significant difference in survival …
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Rational enzyme-directed prodrug development : exploiting tumour hypoxia to target the bioactivation of cytotoxic prodrugs
… to neoplastic tissues. Appropriate expression of therapeutic enzymes can be achieved by exploiting the genetic distinctions that exist between tumour and normal tissues through the use of tissue- or disease-specific promoters. Alternatively, the unique physiological differences that arise in solid …
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Advancing multiple model-based control of complex biological systems: Applications in T cell biology
… regulators of the adaptive immune response against invading pathogens and cancerous host cells. The process of activation is mediated by the T cell receptor and a vast network of intracellular signal transduction pathways, which recognize and interpret antigenic signals to determine the …
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The proteomic analysis of resistance to anticancer therapy in human breast cancer
… the serious life-threatening side effects for no therapeutic gain. The immediate implementation of a more appropriate treatment strategy may also prevent disease progression and such biomarkers would also suggest new drug targets and/or sensitising agents for future therapeutic intervention.The …