Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Therapeutic failure"”.
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An analysis of therapeutic failure in psychotherapy with a deaf client : a training psychologist's experience
… to understand the early stages of a psychotherapeutic process between a trainee psychologist and a Deaf client. Both a social constructionist perspective of the experience of being disabled/Deaf, and an intersubjective lens, have been utilized in order to understand the nature of the …
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Single cell landscape of innate and adaptive immunity in metastatic melanoma treated with immunotherapy
… the adaptive immunity could reflect tumor-level therapeutic failure. We further characterized the T cell diversity in the tumors and discovered an early activated state and a terminally exhausted T cell state with therapeutic potential. Among the innate immune mediators of tumor microenvironment, …
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Quantitation of Anti-Infectious Disease Molecules Utilizing Paper Spray Mass Spectrometry
… agents increases the likelihood of therapeutic failure and resistance. Dosing optimization, while an attractive approach to combat these issues, is difficult to implement due to the different pharmacokinetics of each individual. These limitations highlight the inadequacies of a …
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Analytical and metabolic studies of the trypanocidal diamidines
… plasma concentration, leading to toxification or therapeutic failure. The metabolism of diminazene and pentamidine in isolated rat and pig hepatocytes have been investigated. Diminazene was not metabolized in either rat or pig hepatocytes. While there were no obvious qualitative differences in the …
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Nonlinear mixed-effects modelling of drug-drug interactions between antiretroviral therapy and tuberculosis treatment
… safety and efficacy, potentially leading to therapeutic failure and increased risk of drug resistance. In this thesis, we utilized non-linear mixed effects modelling and data from studies in PWH and healthy volunteers to characterize DDIs between first- and second-line antiretroviral (ARV) …
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Investigation of the anti-breast cancer efficacy and mechanisms of disulfiram
… a major challenge. The main limitation of therapeutic failure is the de novo and acquired resistance of BC cells to conventional anticancer drugs. Cancer stem cells (CSCs) have been thought to be responsible for the chemoresistance. My study demonstrated that mammospheres manifested CSC …
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Expression and activity of enzymes in the human placenta: pharmacological & toxicological consequences in AZT therapy
… in terms of maternal whole-body clearance. Therapeutic failure of AZT in protecting the fetus is unlikely to be due to metabolism and clearance performed by the placenta but may be due to placental cytotoxicity. The development of the perfusion model into the first trimester placenta is …
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Investigation of chemoresistant mechanisms in triple negative breast cancer cell lines and development of a nano-enabled Disulfiram for breast cancer treatment
… drugs is a major limitation and cause of therapeutic failure. Cancer stem cells (CSCs) are believed to be responsible for chemoresistance and tumour relapse. My study demonstrates that hypoxia is involved in the development and maintenance of these CSCs traits in TNBC, as cells grown in …
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CHARACTERIZATION OF EPCAM IN THYROID CANCER BIOLOGY BY THREE-DIMENSIONAL SPHEROIDS IN VITRO MODEL.
… the mechanisms responsible for insensitivity to therapeutic treatments, tumor aggressiveness and tumor relapse described in undifferentiated thyroid cancers (UTCs) haven’t been fully elucidated yet. The insurgence of therapy resistance and disease relapse is believed to be due to a subpopulation …
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Decoding Disease Drivers Through Single-Cell Omics and Scalable Phenotypic Screens
… basis underlying disease progression and therapeutic failure is still required to devise new strategies for improving patient outcomes. Technological advancements in biomedical research, especially in single-cell omics (e.g. single-cell RNA sequencing, single-cell spatial profiling) have …
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Overcoming Tumor Drug Resistance By Activating Amp-Activated Protein Kinase And Destabilizing Oncoproteins
… has been achieved in the field of cancer therapeutics, primary or acquired drug resistance remains a fundamental cause of therapeutic failure in cancer therapy. Among different mechanisms characterized that are responsible for tumor drug resistance, there is increasing evidence suggesting …
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Características epidemiológicas y factores asociados a falla terapéutica a betalactámicos en infecciones de piel y tejidos blandos en pediatría, 2020-2023
Introducción: Las infecciones de piel y tejidos blandos (IPTB) son uno de los principales motivos de consulta. Reconocer el papel del Staphylococcus aureus es fundamental para determinar el antibiótico empírico, ya que el incremento de cepas de S. aureus resistente a meticilina (SARM) ha generado …
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Revisión sistemática de la efectividad pronóstica del índice ROX como predictor de falla terapéutica con cánula nasal de alto flujo (CNAF) en pacientes con neumonía por COVID-19
Antecedentes: El Síndrome de Distrés Respiratorio Agudo (SDRA) generado por el virus SARS-CoV-2 (COVID-19) es una patología emergente que ha provocado desafíos a nivel mundial para el diagnóstico, seguimiento, tratamiento y manejo de complicaciones asociadas. Dentro de la literatura existen pocas …