Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Therapeutic dose"”.
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Dual task performance and antihistimine use
… evidence that there are behavioral effects at therapeutic dose levels. Therefore, the objective of this research was to determine whether a complex cognitive and motor task (memory search and tracking combination) showed a performance deterioration under the influence of two antihistamines …
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The effects of antihistamine use on visual search tasks
… and astemizole) administered at a therapeutic dose level will affect a subject's visual search capabilities. The results of this research indicate that astemizole did not significantly decrement a subject’s ability to visually search as compared to the performance of that same …
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Metastatic cell responses to anticancer therapy: The possible role of cancer stem cells
… if the progeny of cancer cells that survive a therapeutic dose of X-radiation show differences in aberrant glycosylation associated with metastasis, EMT markers and their ability to invade compared to unirradiated cells. The study also aims to investigate the bystander effect of extracellular …
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EXPLORATION OF STRONTIUM UPTAKE BY BONE AND SOFT TISSUES USING STABLE ISOTOPE TECHNIQUES
… chemical and physiological properties. High doses of strontium are known to reduce fracture risk. A tracer study in sheep revealed that bone-seeking tracers (Ca-41 and Sr-86) are incorporated into the bone matrix by remodeling processes favoring trabecular bone and that changes in net bone …
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Vliv výběru typu a energie fotonového svazku na ozařovací plán při zevní radioterapii karcinomu děložního hrdla
… body receiving at least 10 % of the prescribed dose and the total irradiation time. The results showed differences between the individual energies both in the extent of irradiated healthy tissue volume and in the time required to deliver the therapeutic dose. Differences in the body volume …
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Risk of Second Malignant Neoplasms Following Proton Arc Therapy and Volumetric Modulated Arc Therapy For Prostate Cancer
… created for both modalities for three patients. Therapeutic dose was obtained with differential dose-volume histograms from the treatment planning system, and stray dose was estimated from the literature or calculated with Monte Carlo simulations. Then, various risk models were applied to the …
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From Ecological Epitome to Medical Model: An investigation into Applications for the use of Daphnia in Heart Science.
… a high throughput means of testing cardiac therapeutics without resort to small mammal trials. We found Daphnia are inappropriate in this context due to high population variance and sensitivity to small, subtle, environmental changes. A new aim was developed to determine whether beat-to-beat …
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Drug delivery during breastfeeding: investigations of formulations and clinical feasibility
… potential, feasibility, and acceptability of therapeutic delivery during breastfeeding. In a clinical context, a descriptive qualitative study revealed the need for alternative infant oral drug delivery technologies in high-resource settings, and parents' and nursing staff's positive response …
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PEGylated Tissue Repair Peptide TP508 Derivatives as Second Generation Drugs for Radiomitigation and Other Systemic Applications
TP508 is a therapeutic peptide that represents a specific receptor-binding domain of human thrombin with many potential clinical applications. However, it shares several weaknesses common to peptides when administered systemically, such as a short circulating half-life and rapid proteolytic …
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Assessment of imaging dose from the kilovoltage cone beam computed tomography system on board the Varian Halcyon linear accelerator
… about the contribution of low-energy radiation dose to the overall integral dose and possible induction of secondary primary tumours. In this study, the dose to organs and tissues located in the pelvic and thoracic regions of the body from kV CBCT imaging was estimated using the GATE Monte Carlo …
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Radiogenic Second Cancer Risk Differences In Female Hodgkin Lymphoma Patients Treated With Proton Versus Photon Radiotherapies
… Proton therapy has been shown to reduce the therapeutic dose, and therefore, the risk of developing a RSC, to healthy tissue relative to HL photon therapy. Current commercial treatment planning systems (TPS) do not account for stray radiation doses for these treatments, however. The impact of …
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Development of Novel Peptide-Doxorubicin Conjugates for Targeting Triple-Negative Breast Cancer
… however, the side effects limit the effective therapeutic dose. To selectively target the cancer cells, I have synthesized three peptide-drug conjugates (PDCs) to specifically target the TNBC cells. The first PDC contains peptide 18-4 with an additional cysteine in the N-terminal (NH2- …
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Analytical validation and evaluation of the effects of intramuscular injections on acute phase proteins in horses
… of PPG administered twice daily at a recommended therapeutic dose (days 0 to 4), and for 20 days following the final injection (days 5 to 24). Results showed a significant increase in CK activity on days 1-6 and an increase in AST activity on days 2-7 and 10. A significant increase in plasma FIB …
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Melatonin as a novel cardioprotective therapy in pulmonary hypertension
… nutritional concentration), 4mg/kg or 6mg/kg (therapeutic dose) was given daily in the drinking water of rats, with the treatment started 5 days before the injection of MCT, on the day of the injection or 14 days after the injection of MCT. The development of PH was measured by assessing right …
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Accelerator-Based Neutron Branchytherapy
… tumors which limits the diameter of the dose delivery needle tube to 6 mm. A prototype needle tube, a tube-in-tube design with cooling water running in between the inner and outer tubes to cool the beryllium target located at the tip of the inner tube, has been tested to a heat load near …
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Investigations into the use of continuous low-level medication for the control of helminths in the ruminant
… acid and paraffin wax) when the boluses were dosed singly or in pairs. The development of a stable "carrier" on which to load a suitable matrix is also described, the majority of the experiments undertaken utilising this "carrier". The effect on the drug release rate of incorporating various …
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Design of novel delivery systems to probe alternative routes of administration for a self-amplifying RNA rabies vaccine
… to enhance the immunogenicity and to reduce the therapeutic dose compared to conventional non-amplifying mRNA vaccines.;RNAs can be encapsulated in delivery systems to protect them against degradation upon injection and to facilitate their delivery in host cells. Among them, lipid-based delivery …
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Role of the Innate Immune Response to DNA During Therapy with Oncolytic Viruses
… also allows OVs to potentially increase their therapeutic dose over time as they replicate and spread throughout tumours. Whilst tumour lysis helps reduce tumour burden, a secondary purpose of OVs as immunotherapies is to stimulate the host's immune system culminating in a systemic anti-tumour …
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Radiation-induced genomic instability and cellular communication: mechanistic investigations
… system. The cells were irradiated with two doses of X-ray; 0.1 Gy (a iagnostic procedure relevant dose) and 2 Gy (therapeutic dose) and a sham-irradiation dose of 0 Gy (for control groups of experiment). The co-culturing time was 4 hours for all cell combination, whereupon a media transfer …
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The impact of acute and chronic administration of short-acting β2-agonists on urinary pharmacokinetics and athletic performance
… observed between groups, indicating long-term therapeutic use of salbutamol at the WADA upper daily limit has no ergogenic effect. Of note, one participant exceeded the urinary threshold, presenting with an adverse analytical finding (AAF) showing that the upper daily limit can lead to AAF’s in …
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