Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Therapeutic Vaccine"”.
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Expression optimization of a human papillomavirus type 16 therapeutic vaccine candidate in Nicotiana benthamiana leaves
… cervical cancer. The three approved prophylactic vaccines do not benefit already infected individuals; therefore, there is still an urgent need for therapeutic vaccines. The HPV oncoproteins E6 and E7 are ideal targets for the development of such vaccines, as they are expressed throughout the …
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Intranasal Hpv Peptide Vaccine Formulation Induces Potent Cytotoxic Cd8 T Cell Immunity For The Treatment of Genital Hpv Tumors
… HPV cancers are textbook candidates for therapeutic vaccination intervention because they’re driven by the expression of viral oncoproteins E6 and E7, which serve as ideal tumor specific antigen targets. An effective therapeutic vaccine should be able to overcome tumor mechanisms of …
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Importance of specific NK cell subsets for antitumor immunity in HPV+ cancers
… NK subset expressing the DC marker CD11c, via therapeutic HPV peptide vaccination, contribute to tumor-free long-term survival.</p> <p>In addition to antigen-specific CD8 T cell responses, overall innate immune effector responses, including polyfunctional NKDC, were elevated in mice treated …
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Working towards a plant-produced Bovine papillomavirus vaccine: expression of BPV1 virus-like particles and pseudovirions in Nicotiana benthamiana
… in livestock. There is a demand for prophylactic vaccines to immunise animals routinely and from a young age so as to prevent infection from occurring, as there is currently no fully effective treatment against established disease. Virus-like particles (VLPs) have in recent years been adopted as …
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Immunogenic assessment of plant-produced Human papillomavirus type 16 chimaeric L1:L2 virus-like particles and the production of an encapsidated therapeutic DNA vaccine candidate
… an estimated 266 000 deaths every year. Current vaccines are based on the immunodominant L1 major capsid protein, which assembles into virus-like particles (VLPs) that are highly effective in type-specific prevention of cervical infection. However, these vaccines are produced in expensive cell …
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Role of envelope compactness and glycosylation in HIV-1 resistance to neutralising antibody responses
… may contribute to the design of a high-coverage vaccine. This thesis explores the mechanism used by a Tier 3 virus leading to its high antibody neutralisation resistance phenotype. This thesis also describes how the glycans at the base of the V3 loop contribute to (i) breadth and potency in a …