Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 629 for “"Therapeutic Targets"”.
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Ceramides as Therapeutic Targets in Bronchopulmonary Dysplasia
Bronchopulmonary dysplasia (BPD) is a chronic lung disorder associated with extremely premature birth, resulting from arrested development of the microvasculature and consequently disrupted alveologenesis. Premature infants are dependent on respiratory support, including oxygen supplementation and …
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Novel Prognostic Markers and Therapeutic Targets for Glioblastoma
… of applicable prognostic markers and effective therapeutic targets. By employing a loss of function RNAi screen in glioblastoma cells we found a list of 20 kinases that can be considered glioblastoma survival kinases. These survival kinases which we term as survival kinase genes, (SKGs) were …
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Identification of Therapeutic Targets for Th17 Cell-Mediated Diseases
… diseases and may also potentially identify new targets for their treatment. In this study, we worked on two diseases: hypersensitivity pneumonitis (HP) and multiple sclerosis (MS). Both of them can be mediated by Th17 cells. HP is a hypersensitivity disease in the lung which may result in …
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Identifying novel therapeutic targets for seizures and brain cancers
… caused by dysfunctional EAAT2 may be a therapeutic target in such diseases. Therefore, I investigated strategies to modulate the expression of EAAT2, identifying peroxisome proliferator gamma (PPARγ) agonists as a promising candidate. I utilised Immortalised glioblastoma cell lines to …
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Identifying Common Therapeutic Targets in Merlin-deficient Brain Tumours
… them largely unresponsive to classic chemotherapeutic agents leaving surgery and radiosurgery as the only remaining treatment options. Depending on their location, NF2-related tumours can cause a number of side effects, including nausea, balance problems, and in some cases hearing and/or …
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
Exaggerated systemic inflammatory response syndrome may lead to multiple organ dysfunction, organ failure and eventually death. Chemokines, a large family of small chemotactic cytokines, are critical inflammatory mediators in the development of both acute pancreatitis and sepsis. The present study …
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Identification of new therapeutic targets for undifferentiated pleomorphic sarcoma
… challenges in the successful development of new therapeutic options and their translation to the clinic. High-throughput screening in well-annotated preclinical models is a promising approach to identifying novel compounds for further research. This project aims to (i) develop and characterise …
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Investigating novel therapeutic targets for treatment of visceral pain.
… The aim of this thesis is to evaluate novel therapeutic approaches to the treatment of visceral pain in gastrointestinal diseases by: • Studying the effect of calcium activated potassium (KCa) channel openers on the activation of colonic afferents by prototypic algogenic stimuli. • Examining …
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APPROACHES OF MODULATION OF THERAPEUTIC TARGETS RELEVANT TO DRUG RESISTANCE
… anticancer strategy is to identify molecular targets that when inhibited pharmacologically, result in pleiotropic downstream effects on pathways relevant to the malignant phenotype, with particular reference to the development of resistance. In recent years, the molecular chaperone Hsp90 has …
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Dynamic Molecular Mechanisms and Drug Design of Important Therapeutic Targets
… GPCRs constitute the largest family of drug targets. The CXCR4 chemokine receptor, in particular, helps promote HIV entry into host cells. Polycystin-1 (PC1) is an atypical GPCR with 11 transmembrane domains. Mutations in the PC1 protein are responsible for the majority cases of a potentially …
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Candidate tumour markers and potential therapeutic targets in colorectal cancer.
… surgical resection for CRC and as potential therapeutic targets. Results: cDNA microarray screening identified Dipeptidase-1 (DPEP-l) to be over-expressed by > 2 fold in colon tumour compared to normal colonic mucosal tissue in 56/68 (82%) patients. The laminin gamma-2 chain of laminin-5 …
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Translational phosphoproteomics methods to identify biomarkers and novel therapeutic targets
… mediated signaling networks in tumors can inform therapeutic interventions. Additionally, analysis of phosphoproteome in response to drug candidates can help identify biomarkers for therapeutic response as well as lend direct insights into potential adaptive resistance mechanisms. However, …
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Vascular Kv7 (KCNQ) Potassium Channels As Therapeutic Targets in Cerebral Vasospasm
… cerebral vasospasm is poorly understood and the therapeutic options are limited.</p><p>Kv7 (KCNQ) potassium channels are reported to be critical determinants of resting membrane voltage in several excitable cells including neurons and vascular myocytes. Recent findings from our laboratory …
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Identification and Application of Novel Therapeutic Targets for PRPH2-Associated Disorders
… make it imperative to identify a ubiquitous therapeutic target. We attempted to identify pan-mutation therapeutic strategies by targeting OS structural abnormalities associated with Prph2 mutations as well as investigating disruptions in the metabolic symbiosis between the retina and RPE. In …
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Characterisation of leptin mimetic agents as therapeutic targets in Alzheimer's disease
… survival. Therefore, leptin may be an important therapeutic target in the treatment of AD. However, as leptin has many different roles in the periphery and CNS, developing smaller leptin-like molecules with specific actions may be a more ideal therapeutic approach.<br/><br/>Recent studies …
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Identification of therapeutic targets and dependencies in ZNF703-amplified breast cancer
… mechanisms are poorly understood. To identify therapeutic vulnerabilities for ZNF703-amplified breast cancers, wholegenome CRISPR-Cas9 screens were performed in isogenic cell lines with modulated ZNF703 expression alongside ZNF703-amplified cells. Here we report that ZNF703 amplification is …
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Identification and validation of new therapeutic targets for squamous cell lung cancer
… worldwide. Despite recent advancements in cancer therapeutics, no targeted therapies have been approved specifically for LUSC. The lineage- survival oncogene and transcription factor SOX2 is dysregulated by gene amplification in a large proportion of LUSC tumours and has been implicated as a key …
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Identifying Mechanisms Of Resistance And Potential Therapeutic Targets For Pediatric Acute Myeloid Leukemia
… there is a need for the development of new therapeutic approaches for these patients. In the second half of this work, we investigated the response of 2 DS AML cell lines, CMK and CMY, to the combination of araC and one of either the aurora A kinase inhibitor MLN8237, the aurora B kinase …
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Translational Frontiers for Chikungunya Virus: New World Epidemic, New Strains, New Therapeutic Targets
… life-years, an FDA-approved CHIKV vaccine or therapeutic remains elusive. This project addresses two aspects of therapeutic development: surveillance and drug target development. First, an outbreak of CHIKF in La Romana, Dominican Republic is described. During this outbreak, several parameters …
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